Docetaxel with prednisone or prednisolone for the treatment of ...

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174 Appendix 11 TABLE 63 Drug and administration costs for docetaxel + estramustine + prednisone (70) Dose Mean body surface (m 2 ) 1.9 Dose per cycle (mg/m 2 ) 70 Total dose per cycle (mg) 133 No. of cycles 7.3 Total cumulated dose 970.9 Drug cost Docetaxel £7,467.90 Prednisone £7.45 Estramustine £675.19 Warfarin £15.22 Dexamethasone £364.85 Total drug cost £8,530.61 Administration costs £1,295.46 Total drug and administration cost £9,826.07 TABLE 64 Drug and administration costs for docetaxel + estramustine + prednisone (35) Dose Mean body surface (m 2 ) 1.9 Dose per cycle (mg/m 2 ) 35 Total dose per cycle (mg) 66.5 No. of cycles 7.3 Total cumulated dose 485.45 Drug cost Docetaxel £7,807.35 Prednisone £7.45 Estramustine £675.19 Warfarin £15.22 Dexamethasone £729.71 Total drug cost £9,234.91 Administration costs £2,590.92 Total drug and administration cost £11,825.83 TABLE 65 Drug and administration costs for mitoxantrone + prednisone + clodronate Dose Mean body surface (m 2 ) 1.9 Dose per cycle (mg/m 2 ) 12 Total dose per cycle (mg) 22.8 No. of cycles 5.9 Total cumulated dose 134.52 Drug cost Mitoxantrone £998.58 Prednisone £6.02 Clodronate £325.09 Total drug cost £1,329.68 Administration costs £1,047.01 Total drug and administration cost £2,376.99
Scenario: moderate disease (Chapman B) ● You have a bearable amount of pain and it is moderately well controlled by medication. ● You feel tense, worried, irritable, sad or depressed sometimes (only once or twice a week). ● Your ability to have sex and to enjoy it has been affected a fair amount by your condition. ● You have occasional difficulties or problems with urinating or bowel function (only once or twice a week). ● You have some difficulty doing usual activities. ● You do less than before and are tired quite a bit of the time. ● You need some assistance with some daily activities (for example, dressing, washing, using the toilet). Scenario: moderate disease (Chapman B) + Taxanes adverse events ● You have a bearable amount of pain and it is moderately well controlled by medication. ● You feel tense, worried, irritable, sad or depressed sometimes (only once or twice a week). ● Your ability to have sex and to enjoy it has been affected a fair amount by your condition. ● You have occasional difficulties or problems with urinating or bowel function (only once or twice a week). ● You have some difficulty doing usual activities. ● You do less than before and are tired quite a bit of the time. ● You need some assistance with some daily activities (for example, dressing, washing, using the toilet). In this scenario you are taking treatment for your condition, which may have the following additional effects: ● You are at risk of serious infections and may spend time in hospital receiving treatment for these. Appendix 12 Health Technology Assessment 2007; Vol. 11: No. 2 Health state descriptions for adverse events analysis © Queen’s Printer and Controller of HMSO 2007. All rights reserved. ● You feel weak and tired much of the time. ● Your hair has fallen out. ● You have moderate diarrhoea and feel nauseated. ● Your appetite is poor. ● You may feel a little short of breath on exertion. ● Your ankles may become swollen and this may affect your ability to walk. ● You experience tingling and numbness in your hands and feet which is sometimes quite severe. Scenario: moderate disease (Chapman B) + Mitoxantrone adverse events ● You have a bearable amount of pain and it is moderately well controlled by medication. ● You feel tense, worried, irritable, sad or depressed sometimes (only once or twice a week). ● Your ability to have sex and to enjoy it has been affected a fair amount by your condition. ● You have occasional difficulties or problems with urinating or bowel function (only once or twice a week). ● You have some difficulty doing usual activities. ● You do less than before and are tired quite a bit of the time. ● You need some assistance with some daily activities (for example, dressing, washing, using the toilet). In this scenario you are taking treatment for your condition, which may have the following additional effects: ● You feel weak and tired much of the time. ● You bruise more easily than usual. ● You feel short of breath, particularly when lying flat, and have swollen ankles which may affect your ability to walk. ● You experience pains in your joints. 175
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A systematic review and economic mo
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A systematic review and economic mo
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Objectives: A systematic review was
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Glossary and list of abbreviations
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Glossary Absolute risk reduction Th
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Glossary continued Expected value o
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Glossary continued Progression-free
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List of abbreviations ASCO American
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xvi Executive summary of study desi
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xviii Executive summary prednisone/
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Description of underlying health pr
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● Patients with severe fluid rete
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Search strategy As stated in Chapte
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consensus and, if necessary, a thir
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Quantity of research available A to
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TABLE 1 Summary of included RCTs St
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TABLE 2 Treatment comparisons relat
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tumour response was reported for on
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TABLE 4 Summary results table for d
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decrease in PSA level (51 and 39% c
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Survival (%) 100 80 60 40 20 0 0 co
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TABLE 8 Summary results table for d
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TABLE 9 Grade 3 or 4 adverse events
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Also used was the core questionnair
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these, 69 patients had measurable t
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Effectiveness of mitoxantrone plus
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over to receive additional mitoxant
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Progression-free survival It is not
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compared with corticosteroids. The
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statistically significant improveme
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Summary of studies included in the
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TABLE 19 Percentage of costs by res
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TABLE 21 Summary of submission by S
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TABLE 24 Other in-trial costs a bod
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TABLE 27 Cost-effectiveness results
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Introduction The review of cost-eff
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TABLE 28 Regression coefficients fr
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cancer QoL estimation. Studies whic
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Localised Metastatic mHRPC Bennet (
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TABLE 34 Unit costs of drugs from t
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were assigned to the total follow-u
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Probability cost-effective given da
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Probability cost-effective given da
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TABLE 43 Utility values including/e
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was set to be 1.5 years based on th
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Population value of implementation/
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76 Discussion (CCI-NOV22) and least
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78 Discussion subsequent chemothera
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Rodolphe Perard received funding fr
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84 References Compendium; 2004. URL
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86 References (D) in patients (pts)
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88 References 100. Aventis Pharma.
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90 References low-dose prednisone i
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92 References 180. Kozloff M, Robin
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94 References locally advanced pros
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96 References 251. Scholz MC, Guess
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Clinical effectiveness Searching fo
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1. Prostatic Intraepithelial Neopla
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19. donataxel 20. doxetal 21. doxmi
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6. Mitozantrone.ti,ab. 7. Mitoxantr
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Texot or Trazoteva or Trixotene or
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1. (docetaxel OR asodecel OR doxeta
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10. (index of wellbeing or quality
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Appendix 2 Excluded studies Study d
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Study details Reason for exclusion
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Meeting: 2004 ASCO Annual Meeting C
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Studies of clinical effectiveness w
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Using the method outlined by Parmar
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Page 183 and 184: Sanofi-Aventis 61 Bloomfield et al.
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Page 202 and 203: Members Chair, Professor Tom Walley
Page 204 and 205: Members Chair, Professor Bruce Camp
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