Docetaxel with prednisone or prednisolone for the treatment of ...

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172 Appendix 10 TABLE 57 Mean standard gamble utilities for health states Health state Mean SD Median Range N Cancer with 20% chance of spread 0.84 0.19 0.89 0.09–1.0 88 Cancer with 40% chance of spread 0.81 0.18 0.81 0.01–1.0 49 Cancer with 75% chance of spread 0.71 0.24 0.79 0.01–1.0 53 Spread asymptomatic 0.67 0.24 0.70 0.01–1.0 46 Metastatic cancer 0.25 0.11 0.11 0–0.9 54 health state was then estimated using the inverse of the accepted level of risk, transformed to a 0–1 scale. Most respondents were reported to have logically ordered ratings, and the mean SG utilities are shown in Table 57. The mean SG utilities for the different health states revealed a lower QoL associated with an increasing probability of tumour spread (0.84–0.67). The utility value estimated for the terminal health state was considerably lower than the asymptomatic states (0.25). Although data based on other approaches (TTO and VAS) were not reported, the mean valuations provided for most health states were described as being similar using TTO and SG and significantly lower using the VAS.
The results of the drug cost calculations are given in Tables 58–65. TABLE 58 Drug and administration costs for docetaxel + prednisone (3-weekly) Appendix 11 © Queen’s Printer and Controller of HMSO 2007. All rights reserved. Health Technology Assessment 2007; Vol. 11: No. 2 Drug cost calculations for each comparator Dose Mean body surface (m 2 ) 1.9 Dose per cycle (mg/m 2 ) 75 Total dose per cycle (mg) 142.5 No. of cycles 7.3 Total cumulated dose 1,040.25 Drug cost Docetaxel £7,807.35 Prednisone £7.45 Dexamethasone £43.36 Total drug cost £7,858.16 Administration costs £1,295.46 Total drug and administration cost £9,153.62 TABLE 59 Drug and administration costs for mitoxantrone + prednisone Dose Mean body surface (m 2 ) 1.9 Dose per cycle (mg/m 2 ) 12 Total dose per cycle (mg) 22.8 No. of cycles 5.9 Total cumulated dose 134.52 Drug cost Mitoxantrone £998.58 Prednisone £6.02 Total drug cost £1,004.59 Administration costs £1,047.01 Total drug and administration cost £2,051.60 TABLE 60 Drug and administration costs for prednisone Drug cost Prednisone £1.48 Total drug cost per cycle £1.48 TABLE 61 Drug and administration costs for docetaxel + prednisone (weekly) Dose Mean body surface (m 2 ) 1.9 Dose per cycle (mg/m 2 ) 150 Total dose per cycle (mg) 285 No. of cycles 3.7 Total cumulated dose 1,054.5 Drug cost Docetaxel £18,925.50 Prednisone £7.55 Dexamethasone £36.63 Total drug cost £18,969.68 Administration costs £656.60 Total drug and administration cost £19,626.28 TABLE 62 Drug and administration costs for docetaxel + estramustine Dose Mean body surface (m 2 ) 1.9 Dose per cycle (mg/m 2 ) 60 Total dose per cycle (mg) 114 No. of cycles 7.3 Total cumulated dose 832.2 Drug cost Docetaxel £6,279.83 Estramustine £375.10 Warfarin £15.22 Dexamethasone £364.85 Total drug cost £7,035.00 Administration costs £1,295.46 Total drug and administration cost £8,330.46 173
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A systematic review and economic mo
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A systematic review and economic mo
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Objectives: A systematic review was
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Glossary and list of abbreviations
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Glossary Absolute risk reduction Th
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Glossary continued Expected value o
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Glossary continued Progression-free
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List of abbreviations ASCO American
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xvi Executive summary of study desi
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xviii Executive summary prednisone/
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Description of underlying health pr
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● Patients with severe fluid rete
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Search strategy As stated in Chapte
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consensus and, if necessary, a thir
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Quantity of research available A to
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TABLE 1 Summary of included RCTs St
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TABLE 2 Treatment comparisons relat
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tumour response was reported for on
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TABLE 4 Summary results table for d
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decrease in PSA level (51 and 39% c
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Survival (%) 100 80 60 40 20 0 0 co
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TABLE 8 Summary results table for d
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TABLE 9 Grade 3 or 4 adverse events
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Also used was the core questionnair
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these, 69 patients had measurable t
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Effectiveness of mitoxantrone plus
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over to receive additional mitoxant
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Progression-free survival It is not
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compared with corticosteroids. The
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statistically significant improveme
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Summary of studies included in the
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TABLE 19 Percentage of costs by res
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TABLE 21 Summary of submission by S
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TABLE 24 Other in-trial costs a bod
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TABLE 27 Cost-effectiveness results
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Introduction The review of cost-eff
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TABLE 28 Regression coefficients fr
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cancer QoL estimation. Studies whic
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Localised Metastatic mHRPC Bennet (
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TABLE 34 Unit costs of drugs from t
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were assigned to the total follow-u
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Probability cost-effective given da
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Probability cost-effective given da
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TABLE 43 Utility values including/e
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was set to be 1.5 years based on th
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Population value of implementation/
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76 Discussion (CCI-NOV22) and least
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78 Discussion subsequent chemothera
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Rodolphe Perard received funding fr
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84 References Compendium; 2004. URL
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86 References (D) in patients (pts)
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88 References 100. Aventis Pharma.
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90 References low-dose prednisone i
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92 References 180. Kozloff M, Robin
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94 References locally advanced pros
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96 References 251. Scholz MC, Guess
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Clinical effectiveness Searching fo
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1. Prostatic Intraepithelial Neopla
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19. donataxel 20. doxetal 21. doxmi
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6. Mitozantrone.ti,ab. 7. Mitoxantr
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Texot or Trazoteva or Trixotene or
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1. (docetaxel OR asodecel OR doxeta
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10. (index of wellbeing or quality
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Appendix 2 Excluded studies Study d
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Study details Reason for exclusion
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Meeting: 2004 ASCO Annual Meeting C
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Studies of clinical effectiveness w
Page 141 and 142: Using the method outlined by Parmar
Page 143 and 144: Appendix 6 Data extraction tables
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Page 178 and 179: 158 Appendix 7 Ernst et al. 33 Qual
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Page 183 and 184: Sanofi-Aventis 61 Bloomfield et al.
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Page 196 and 197: 176 Appendix 12 Scenario: moderate
Page 198 and 199: 178 Appendix 13 ● You occasionall
Page 202 and 203: Members Chair, Professor Tom Walley
Page 204 and 205: Members Chair, Professor Bruce Camp
Page 207: Feedback The HTA Programme and the
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