Docetaxel with prednisone or prednisolone for the treatment of ...

The results of the drug cost calculations are
given in Tables 58–65.
TABLE 58 Drug and administration costs for docetaxel +
prednisone (3-weekly)
Appendix 11
© Queen’s Printer and Controller of HMSO 2007. All rights reserved.
Health Technology Assessment 2007; Vol. 11: No. 2
Drug cost calculations for each comparator
Dose
Mean body surface (m 2 ) 1.9
Dose per cycle (mg/m 2 ) 75
Total dose per cycle (mg) 142.5
No. of cycles 7.3
Total cumulated dose 1,040.25
Drug cost
Docetaxel £7,807.35
Prednisone £7.45
Dexamethasone £43.36
Total drug cost £7,858.16
Administration costs £1,295.46
Total drug and administration cost £9,153.62
TABLE 59 Drug and administration costs for mitoxantrone +
prednisone
Dose
Mean body surface (m 2 ) 1.9
Dose per cycle (mg/m 2 ) 12
Total dose per cycle (mg) 22.8
No. of cycles 5.9
Total cumulated dose 134.52
Drug cost
Mitoxantrone £998.58
Prednisone £6.02
Total drug cost £1,004.59
Administration costs £1,047.01
Total drug and administration cost £2,051.60
TABLE 60 Drug and administration costs for prednisone
Drug cost
Prednisone £1.48
Total drug cost per cycle £1.48
TABLE 61 Drug and administration costs for docetaxel +
prednisone (weekly)
Dose
Mean body surface (m 2 ) 1.9
Dose per cycle (mg/m 2 ) 150
Total dose per cycle (mg) 285
No. of cycles 3.7
Total cumulated dose 1,054.5
Drug cost
Docetaxel £18,925.50
Prednisone £7.55
Dexamethasone £36.63
Total drug cost £18,969.68
Administration costs £656.60
Total drug and administration cost £19,626.28
TABLE 62 Drug and administration costs for docetaxel +
estramustine
Dose
Mean body surface (m 2 ) 1.9
Dose per cycle (mg/m 2 ) 60
Total dose per cycle (mg) 114
No. of cycles 7.3
Total cumulated dose 832.2
Drug cost
Docetaxel £6,279.83
Estramustine £375.10
Warfarin £15.22
Dexamethasone £364.85
Total drug cost £7,035.00
Administration costs £1,295.46
Total drug and administration cost £8,330.46
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