Docetaxel with prednisone or prednisolone for the treatment of ...

More documents

Recommendations

Info

vi Contents Appendix 13 Health state descriptions based on FACT-P ........................................ 177 Appendix 14 WinBUGS code for adverse events analysis ............................................ 179 Health Technology Assessment reports published to date ....................................... 181 Health Technology Assessment Programme ................................................ 195
Glossary Absolute risk reduction The difference between the event rates in the two groups; if the adverse event rate is less in the intervention group, this suggests that the intervention is beneficial. Adverse effect/adverse event An abnormal or harmful effect caused by, and attributable to, exposure to a chemical (e.g. a drug), which is indicated by some result such as death, a physical symptom or a visible illness. An event may be classified as adverse if it causes functional or anatomical damage, causes irreversible changes in the homeostasis of the organism or increases the susceptibility of the organism to other chemical or biological stress. Alopecia Baldness/loss of body hair. Anaemia An abnormally low level of red blood cells in the blood. Red blood cells are responsible for carrying oxygen around the body. Antineoplastic Inhibiting or preventing the development of neoplasms, and checking the maturation and proliferation of malignant cells. Arthralgia Joint pain. © Queen’s Printer and Controller of HMSO 2007. All rights reserved. Health Technology Assessment 2007; Vol. 11: No. 2 Glossary and list of abbreviations Technical terms and abbreviations are used throughout this report. The meaning is usually clear from the context, but a glossary is provided for the non-specialist reader. In some cases, usage differs in the literature, but the term has a constant meaning throughout this review. Asthenia Weakness, lack of energy and strength. Bias Deviation of results or inferences from the truth, or processes leading to such deviation. Any trend in the collection, analysis, interpretation, publication or review of data that can lead to conclusions that are systematically different from the truth. Blinding A procedure used in clinical trials to avoid the possible bias that might be introduced if the patient and/or doctor knew which treatment the patient would be receiving. If neither the patient nor the doctor is aware of which treatment has been given, the trial is termed ‘double-blind’. If only one of the patient or doctor is aware, the trial is called ‘single-blind’. Carcinoma A cancerous growth. Censored data Censorship means that the event does not occur during the period of observation and the time of event is unknown, but these cases are incorporated into the analysis. Those whose event is unknown or who are lost to the study (right censored), or new patients introduced into the study (left censored), add to the information on patients whose event time is known (uncensored) at each time interval. Chemotherapy The use of drugs that are capable of killing cancer cells or preventing/slowing their growth. Clodronate A medicine used to treat a high level of calcium in the blood caused by changes in the body that happen with cancer. Clodronate also treats the weakening in the bones when cancer has spread to the bones from another part of the body. Co-intervention In a randomised controlled trial, the application of additional diagnostic or therapeutic procedures to members of either the experimental or reference group, or to both groups. continued vii
Page 1 and 2: A systematic review and economic mo
Page 3 and 4: A systematic review and economic mo
Page 5 and 6: Objectives: A systematic review was
Page 7: Glossary and list of abbreviations
Page 11 and 12: Glossary continued Expected value o
Page 13 and 14: Glossary continued Progression-free
Page 15: List of abbreviations ASCO American
Page 18 and 19: xvi Executive summary of study desi
Page 20 and 21: xviii Executive summary prednisone/
Page 23 and 24: Description of underlying health pr
Page 25 and 26: ● Patients with severe fluid rete
Page 27 and 28: Search strategy As stated in Chapte
Page 29 and 30: consensus and, if necessary, a thir
Page 31 and 32: Quantity of research available A to
Page 33 and 34: TABLE 1 Summary of included RCTs St
Page 35 and 36: TABLE 2 Treatment comparisons relat
Page 37 and 38: tumour response was reported for on
Page 39 and 40: TABLE 4 Summary results table for d
Page 41 and 42: decrease in PSA level (51 and 39% c
Page 43 and 44: Survival (%) 100 80 60 40 20 0 0 co
Page 45 and 46: TABLE 8 Summary results table for d
Page 47 and 48: TABLE 9 Grade 3 or 4 adverse events
Page 49 and 50: Also used was the core questionnair
Page 51 and 52: these, 69 patients had measurable t
Page 53 and 54: Effectiveness of mitoxantrone plus
Page 55 and 56: over to receive additional mitoxant
Page 57 and 58: Progression-free survival It is not
Page 59 and 60:
compared with corticosteroids. The
Page 61 and 62:
statistically significant improveme
Page 63 and 64:
Summary of studies included in the
Page 65 and 66:
TABLE 19 Percentage of costs by res
Page 67 and 68:
TABLE 21 Summary of submission by S
Page 69 and 70:
TABLE 24 Other in-trial costs a bod
Page 71 and 72:
TABLE 27 Cost-effectiveness results
Page 73 and 74:
Introduction The review of cost-eff
Page 75 and 76:
TABLE 28 Regression coefficients fr
Page 77 and 78:
cancer QoL estimation. Studies whic
Page 79 and 80:
Localised Metastatic mHRPC Bennet (
Page 81 and 82:
TABLE 34 Unit costs of drugs from t
Page 83 and 84:
were assigned to the total follow-u
Page 85 and 86:
Probability cost-effective given da
Page 87 and 88:
Probability cost-effective given da
Page 89 and 90:
TABLE 43 Utility values including/e
Page 91 and 92:
was set to be 1.5 years based on th
Page 93:
Population value of implementation/
Page 96 and 97:
76 Discussion (CCI-NOV22) and least
Page 98 and 99:
78 Discussion subsequent chemothera
Page 101:
Rodolphe Perard received funding fr
Page 104 and 105:
84 References Compendium; 2004. URL
Page 106 and 107:
86 References (D) in patients (pts)
Page 108 and 109:
88 References 100. Aventis Pharma.
Page 110 and 111:
90 References low-dose prednisone i
Page 112 and 113:
92 References 180. Kozloff M, Robin
Page 114 and 115:
94 References locally advanced pros
Page 116 and 117:
96 References 251. Scholz MC, Guess
Page 119 and 120:
Clinical effectiveness Searching fo
Page 121 and 122:
1. Prostatic Intraepithelial Neopla
Page 123 and 124:
19. donataxel 20. doxetal 21. doxmi
Page 125 and 126:
6. Mitozantrone.ti,ab. 7. Mitoxantr
Page 127 and 128:
Texot or Trazoteva or Trixotene or
Page 129 and 130:
1. (docetaxel OR asodecel OR doxeta
Page 131 and 132:
10. (index of wellbeing or quality
Page 133 and 134:
Appendix 2 Excluded studies Study d
Page 135 and 136:
Study details Reason for exclusion
Page 137 and 138:
Meeting: 2004 ASCO Annual Meeting C
Page 139 and 140:
Studies of clinical effectiveness w
Page 141 and 142:
Using the method outlined by Parmar
Page 143 and 144:
Appendix 6 Data extraction tables
Page 145 and 146:
Study details and Participant detai
Page 147 and 148:
Page 149 and 150:
Page 151 and 152:
Page 153 and 154:
Page 155 and 156:
Page 157 and 158:
Page 159 and 160:
Page 161 and 162:
Page 163 and 164:
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Page 175:
Page 178 and 179:
158 Appendix 7 Ernst et al. 33 Qual
Page 181 and 182:
Appendix 9 © Queen’s Printer and
Page 183 and 184:
Sanofi-Aventis 61 Bloomfield et al.
Page 185:
Sanofi-Aventis 61 Bloomfield et al.
Page 188 and 189:
168 Appendix 10 TABLE 51 Mean (SD)
Page 190 and 191:
170 Appendix 10 TABLE 54 Distributi
Page 192 and 193:
172 Appendix 10 TABLE 57 Mean stand
Page 194 and 195:
174 Appendix 11 TABLE 63 Drug and a
Page 196 and 197:
176 Appendix 12 Scenario: moderate
Page 198 and 199:
178 Appendix 13 ● You occasionall
Page 202 and 203:
Members Chair, Professor Tom Walley
Page 204 and 205:
Members Chair, Professor Bruce Camp
Page 207:
Feedback The HTA Programme and the
show all

Docetaxel with prednisone or prednisolone for the treatment of ...

Create successful ePaper yourself

Delete template?

Save as template?