credits bmbl December 7 '06.doc - Central Michigan University

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Vertebrate Animal Biosafety Level Criteria – Animal Biosafety Level 4 2. Animal Welfare Act and Amendment, Title 9 C.F.R. Subchapter A, Parts 1, 2, 3 (1976). 3. National Research Council; Institute for Laboratory Animal Research. Occupational health and safety in the care of research animals. Washington, DC: National Academy Press; 1996. 4. National Research Council; Institute for Laboratory Animal Research. Occupational health and safety in the care and use of nonhuman primates. Washington, DC: National Academy Press; 2003. 5. National Institutes of Health, Office of Laboratory Animal Welfare. Public Health Service policy on humane care and use of laboratory animals, Bethesda (MD); The National Institutes of Health (US); 2000. 118
TABLE 1 SUMMARY OF RECOMMENDED BIOSAFETY LEVELS FOR ACTIVITIES IN WHICH EXPERIMENTALLY OR NATURALLY INFECTED VERTBRATE ANIMALS ARE USED. ABSL AGENTS PRACTICES PRIMARY BARRIERS AND SAFETY EQUIPMENT 1 Not known to consistently cause diseases in Standard animal care and management As required for normal care of each healthy adults practices, including appropriate medical species surveillance programs 2 • Associated with human disease • Hazard: percutaneous exposure, ingestion, mucous membrane exposure. 3 • Indigenous or exotic agents with potential for aerosol transmission • Disease may have serious health effects 4 • Dangerous/exotic agents that pose high risk of life threatening disease • Aerosol transmission, or related agents with unknown risk of transmission ABSL-1 practice plus: • Limited access • Biohazard warning signs • “Sharps” precautions • Biosafety manual • Decontamination of all infectious wastes and of animal cages prior to washing ABSL-2 practice plus: • Controlled access • Decontamination of clothing before laundering • Cages decontaminated before bedding removed • Disinfectant foot bath as needed ABSL-3 practices plus: • Entrance through change room where personal clothing is removed and laboratory clothing is put on; shower on exiting • All wastes are decontaminated before removal from the facility ABSL-1 equipment plus primary barriers: • Containment equipment appropriate for animal species PPEs * : • Laboratory coats, gloves, face and respiratory protection as needed ABSL-2 equipment plus: • Containment equipment for housing animals and cage dumping activities • Class I, II or III BSCs available for manipulative procedures (inoculation, necropsy) that may create infectious aerosols. PPEs: • Appropriate respiratory protection ABSL-3 equipment plus: • Maximum containment equipment (i.e., Class III BSC or partial containment equipment in combination with full body, airsupplied positive-pressure personnel suit) used for all procedures and activities FACILITIES (SECONDARY BARRIERS) Standard animal facility: • No recirculation of exhaust air • Directional air flow recommended • Hand washing sink is available ABSL-1 plus: • Autoclave available • Hand washing sink available • Mechanical cage washer recommended ABSL-2 facility plus: • Physical separation from access corridors • Self-closing, double-door access • Sealed penetrations • Sealed windows • Autoclave available in facility ABSL-3 facility plus: • Separate building or isolated zone • Dedicated supply and exhaust, vacuum and decontamination systems • Other requirements outlined in the text * PPE – Personal Protective Equipment 119
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Biosafety in Microbiological and Bi
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SECTION VIII-H: Prion Diseases 299
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Forward Biosafety in Microbiologica
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Editors: L. Casey Chosewood, MD Dir
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Guest Editors: Matthew J. Arduino,
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Charles B. Millard, PhD Lieutenant
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Robert Bull Karen B. Byers Jane Cap
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Thomas L. Miller Douglas M. Moore M
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Robert Yarchoan Uri Yokel Lisa Youn
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Introduction laboratories chose not
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Introduction RISK CRITERIA FOR ESTA
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Introduction BMBL includes an impor
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Section II Biological Risk Assessme
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Biological Risk Assessment informat
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Biological Risk Assessment The NIH
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Biological Risk Assessment effectiv
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Biological Risk Assessment Third, m
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Biological Risk Assessment 14. Oxma
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Principles of Biosafety Safety equi
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Principles of Biosafety Often an in
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Principles of Biosafety Four standa
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Principles of Biosafety 4. Centers
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Laboratory Biosafety Level Criteria
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Page 67 and 68: Laboratory Biosafety Level Criteria
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Page 121 and 122: Principles of Laboratory Biosecurit
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Agent Summary Statements - Bacteria
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• Section VIII-B: Fungal Agents A
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Agent Summary Statements - Fungal A
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• Section VIII-C: Parasitic Agent
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Agent Summary Statements - Parasiti
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• Section VIII-D: Rickettsial Age
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Agent Summary Statements - Ricketts
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Agent Summary Statements - Ricketts
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• Section VIII-E: Viral Agents Ag
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Agent Summary Statements - Viral Ag
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Agent Summary Statements - Arboviru
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• Section VIII-G: Toxin Agents Se
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Agent Summary Statements - Toxins i
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Agent Summary Statements - Toxins A
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Agent Summary Statements - Toxins L
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Agent Summary Statements - Toxins e
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Agent Summary Statements - Toxins o
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Agent Summary Statements - Toxins t
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• Section VIII-H: Prion Diseases
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Agent Summary Statement - Prion Dis
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Appendix A Proper maintenance of ca
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Appendix A declined. However, in ma
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Appendix A It is possible to exhaus
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Appendix A 4. The Class II, Type A2
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Appendix A prohibited. Furthermore,
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Appendix A plastic wrappers, pipett
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Appendix A touch-plate microburners
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Appendix A SECTION VI FACILITY AND
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Appendix A Development of Containme
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Appendix A C. Airflow Smoke Pattern
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Appendix A TABLES Table 1. Selectio
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Appendix A Table 3. Field Performan
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Appendix A FIGURES Figure 1. HEPA f
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Appendix A Figure 3. The Class II,
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Appendix A Figure 5B. The Class II,
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Appendix A Figure 8. The Class III
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Appendix A Figure 9B. The vertical
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Appendix A Figure 11. A typical lay
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Appendix A REFERENCES 1. Centers fo
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Appendix B Decontamination and Disi
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Appendix B surfaces are contaminate
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Appendix B TABLE 1 DESCENDING ORDER
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Appendix B dioxide gas exits the ge
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Appendix B d The effectiveness of a
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Appendix C Transportation of Infect
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Appendix C 1600 Clifton Road, N.E.,
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Appendix C disease in humans or in
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Appendix C Biological specimen, Cat
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Appendix D Agriculture Pathogen Bio
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Appendix D simultaneous opening of
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Appendix D 14. Pathological inciner
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Appendix D Wastes and other materia
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Appendix D Camelpox virus b a, b, c
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Appendix D SPECIAL ISSUES The impor
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Appendix D required by the USDA and
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Appendix D depression, anorexia, an
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Appendix D laboratory with enhancem
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Appendix D five day period of conta
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Appendix D slaughterhouses or indus
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Appendix D virus does not cause any
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Appendix D NDV is classified in the
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Appendix D movement permit is requi
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Appendix D Spring Viremia of Carp V
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Appendix D REFERENCES 1. Hess WR. A
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Appendix D 37. Alexander DJ. Newcas
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Appendix E Arthropod Containment Gu
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Appendix F Select Agents and Toxins
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Appendix G IPM issues and requireme
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Appendix H Working with Human, NHP
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Appendix I Guidelines for Work with
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decontaminated periodically, for ex
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0.25N, and/or sodium hypochlorite (
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k Irradiation causes a dose-depende
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7. Morin R, Kozlovac J. Biological
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Appendix J NIH Oversight of Researc
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Appendix K Resources for Informatio
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Appendix K E-mail: http://www2.gsu.
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Appendix K and http://www.who.int/c
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Appendix L HEPA High Efficiency Par
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