credits bmbl December 7 '06.doc - Central Michigan University

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Appendix E Four Arthropod Containment Levels (ACL 1-4) add increasingly stringent measures and are similar to biosafety levels. The most flexible level is ACL-2 that covers most exotic and transgenic arthropods and those infected with pathogens requiring BSL-2 containment. Like BMBL, each level has the following form: • standard practices; • special practices; • equipment (primary barriers); • facilities (secondary barriers). The ACG does not reflect a formal endorsement by ACME or ASTMH. The guidelines are subject to change based on further consideration of the requirements for containment of arthropods and vectors. REFERENCES 1. American Committee of Medical Entomology; American Society of Tropical Medicine and Hygiene. Arthropod containment guidelines. A project of the American Committee of Medical Entomology and American Society of Tropical Medicine and Hygiene. Vector Borne Zoonotic Dis. 2003;3:61-98. 398 2
Appendix F Select Agents and Toxins The Public Health Security and Bioterrorism Preparedness and Response Act of 2002, Subtitle A of Public Law 107-188 (42 U.S.C. 262a), requires DHHS to regulate the possession, use, and transfer of biological agents or toxins (i.e., select agents and toxins) that could pose a severe threat to public health and safety. The Agricultural Bioterrorism Protection Act of 2002, Subtitle B of Public Law 107-188 (7 U.S.C. 8401), requires the USDA to regulate the possession, use, and transfer of biological agents or toxins (i.e., select agents and toxins) that could pose a severe threat to animal or plant health, or animal or plant products. These Acts require the establishment of a national database of registered entities, and set criminal penalties for failing to comply with the requirements of the Acts. In accordance with these Acts, DHHS and USDA promulgated regulations requiring entities to register with the CDC or the APHIS if they possess, use, or transfer a select agent or toxin (42 C.F.R. Part 73, 7 C.F.R. Part 331, and 9 C.F.R. Part 121). CDC and APHIS coordinate regulatory activities for those agents that would be regulated by both agencies (“overlap” select agents). The Attorney General has the authority and responsibility to conduct electronic database checks (i.e., the security risk assessments) on entities that apply to possess, use, or transfer select agents, as well as personnel that require access to select agents and toxins. The FBI, Criminal Justice Information Services Division (CJIS), has been delegated authority for conducting these security risk assessments. The regulations provide that, unless exempted, entities must register with CDC or APHIS if they possess, use, or transfer select agents or toxins. The current list of select agents and toxins is available on the CDC and APHIS websites (see below). The regulations set out a procedure for excluding an attenuated strain of a select agent or toxin and exemptions for certain products and for select agents or toxins identified in specimens presented for diagnosis, verification, or proficiency testing. The regulations also contain requirements to ensure that the select agents and toxins are handled safely and secured against unauthorized access, theft, loss, or release. For example, entities and their personnel must undergo a security risk assessment by CJIS as part of their registration; entities must limit access to select agents and toxins and develop and implement biosafety, security, and incident response plans. In addition, all select agents or toxins must be transferred in accordance with the regulations and any theft, loss, or release of a select agent or toxin must be reported to CDC or APHIS. For additional information concerning the select agent regulations, contact CDC or APHIS. Information is also available on the Internet at www.cdc.gov/od/sap and www.aphis.usda.gov/programs/ag_selectagent/index.html. Information concerning security risk assessments is available at www.fbi.gov/terrorinfo/bioterrorfd961.htm. 399
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Biosafety in Microbiological and Bi
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SECTION VIII-H: Prion Diseases 299
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Forward Biosafety in Microbiologica
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Editors: L. Casey Chosewood, MD Dir
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Guest Editors: Matthew J. Arduino,
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Charles B. Millard, PhD Lieutenant
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Robert Bull Karen B. Byers Jane Cap
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Thomas L. Miller Douglas M. Moore M
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Robert Yarchoan Uri Yokel Lisa Youn
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Introduction laboratories chose not
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Introduction RISK CRITERIA FOR ESTA
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Introduction BMBL includes an impor
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Section II Biological Risk Assessme
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Biological Risk Assessment informat
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Biological Risk Assessment The NIH
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Biological Risk Assessment effectiv
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Biological Risk Assessment Third, m
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Biological Risk Assessment 14. Oxma
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Principles of Biosafety Safety equi
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Principles of Biosafety Often an in
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Principles of Biosafety Four standa
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Principles of Biosafety 4. Centers
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Laboratory Biosafety Level Criteria
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Section V Vertebrate Animal Biosafe
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Vertebrate Animal Biosafety Level C
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TABLE 1 SUMMARY OF RECOMMENDED BIOS
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Principles of Laboratory Biosecurit
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Occupational Health and Immunoproph
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Agent Summary Statements - Bacteria
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• Section VIII-B: Fungal Agents A
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Agent Summary Statements - Fungal A
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• Section VIII-C: Parasitic Agent
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Agent Summary Statements - Parasiti
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• Section VIII-D: Rickettsial Age
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Agent Summary Statements - Ricketts
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Agent Summary Statements - Ricketts
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• Section VIII-E: Viral Agents Ag
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Agent Summary Statements - Viral Ag
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• Section VIII-G: Toxin Agents Se
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Agent Summary Statements - Toxins i
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Agent Summary Statements - Toxins A
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• Section VIII-H: Prion Diseases
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Agent Summary Statement - Prion Dis
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Appendix A Proper maintenance of ca
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Appendix A declined. However, in ma
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Appendix A It is possible to exhaus
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Appendix A 4. The Class II, Type A2
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Appendix A prohibited. Furthermore,
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Appendix A plastic wrappers, pipett
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Appendix A touch-plate microburners
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Appendix A SECTION VI FACILITY AND
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Appendix A Development of Containme
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Appendix A C. Airflow Smoke Pattern
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Appendix A TABLES Table 1. Selectio
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Appendix A Table 3. Field Performan
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Appendix A FIGURES Figure 1. HEPA f
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Appendix A Figure 3. The Class II,
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Appendix A Figure 5B. The Class II,
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Appendix A Figure 8. The Class III
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Appendix A Figure 9B. The vertical
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Appendix A Figure 11. A typical lay
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Appendix A REFERENCES 1. Centers fo
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Appendix B Decontamination and Disi
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Page 363 and 364: Appendix D Agriculture Pathogen Bio
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Page 371 and 372: Appendix D Camelpox virus b a, b, c
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Page 391 and 392: Appendix D Spring Viremia of Carp V
Page 393 and 394: Appendix D REFERENCES 1. Hess WR. A
Page 395 and 396: Appendix D 37. Alexander DJ. Newcas
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Page 403 and 404: Appendix H Working with Human, NHP
Page 405 and 406: Appendix I Guidelines for Work with
Page 407 and 408: decontaminated periodically, for ex
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Page 411 and 412: k Irradiation causes a dose-depende
Page 413 and 414: 7. Morin R, Kozlovac J. Biological
Page 415 and 416: Appendix J NIH Oversight of Researc
Page 417 and 418: Appendix K Resources for Informatio
Page 419 and 420: Appendix K E-mail: http://www2.gsu.
Page 421 and 422: Appendix K and http://www.who.int/c
Page 423 and 424: Appendix L HEPA High Efficiency Par
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