credits bmbl December 7 '06.doc - Central Michigan University

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Agent Summary Statements – Bacterial Agents A DoC permit may be required for the export of this agent to another country. See Appendix C for additional information. Agent: Salmonella serotypes, other than S. Typhi Salmonellae are gram-negative enteric bacteria associated with diarrheal illness humans. They are motile oxidase-negative organisms that are easily cultivated on standard bacteriologic media, although enrichment and selective media may be required for isolation from clinical materials. Recent taxonomic studies have organized this genus into two species, S. enterica and S. bongori, containing more than 2500 antigenically distinct subtypes or serotypes. 123 S. enterica contains the vast majority of serotypes associated with human disease. S. enterica serotypes Typhimuruim and Enteritidis (commonly designated S. Typhimurium and S. Enteritidis) are the serotypes most frequently encountered in the United States. This summary statement covers all pathogenic serotypes except S. Typhi. Occupational Infections Salmonellosis is a documented hazard to laboratory personnel. 4,26,124-125 Primary reservoir hosts include a broad spectrum of domestic and wild animals, including birds, mammals, and reptiles, all of which may serve as a source of infection to laboratory personnel. Case reports of laboratory-acquired infections indicate a presentation of symptoms (fever, severe diarrhea, abdominal cramping) similar to those of naturallyacquired infections, although one case also developed erythema nodosum and reactive arthritis. 126,127 Natural Modes of Infection Salmonellosis is a foodborne disease of worldwide distribution. An estimated 5 million cases of salmonellosis occur annually in the United States. A wide range of domestic and feral animals (poultry, swine, rodents, cattle, iguanas, turtles, chicks, dogs, cats) may serve as reservoirs for this disease, as well as humans. 128 The most common mode of transmission is by ingestion of food from contaminated animals or contaminated during processing. The disease usually presents as an acute enterocolitis, with an incubation period ranging from 6 to 72 hours. LABORATORY SAFETY The agent may be present in feces, blood, urine, and in food, feed, and environmental materials. Ingestion or parenteral inoculation are the primary laboratory hazards. The importance of aerosol exposure is not known. Naturally or experimentally infected animals are a potential source of infection for laboratory and animal care personnel, and for other animals. Containment Recommendations 166
Agent Summary Statements – Bacterial Agents Strict compliance with BSL-2 practices, containment equipment, and facilities are recommended for all activities utilizing known or potentially infectious clinical materials or cultures. This includes conducting procedures with aerosol or high splash potential in primary containment devices such as a BSCs or safety centrifuge cups. Personal protective equipment should be used in accordance with a risk assessment, including splash shields, face protection, gowns, and gloves. The importance of proper gloving techniques and frequent and thorough hand washing is emphasized. Care in manipulating faucet handles to prevent contamination of cleaned hands or the use of sinks equipped with remote water control devices, such as foot pedals, is highly recommended. Special attention to the timely and appropriate decontamination of work surfaces, including potentially contaminated equipment and laboratory fixtures, is strongly advised. ABSL-2 facilities and practices are recommended for activities with experimentally infected animals. SPECIAL ISSUES Transfer of Agent Importation of this agent may require CDC and/or USDA importation permits. Domestic transport of this agent may require a permit from USDA/APHIS/VS. A DoC permit may be required for the export of this agent to another country. See Appendix C for additional information. Agent: Salmonella Typhi Recent taxonomic studies have organized the genus Salmonella into two species, S. enterica and S. bongori, containing more than 2500 antigenically distinct subtypes or serotypes. 123 S. enterica contains the vast majority of serotypes associated with human disease. S. enterica serotype Typhi, commonly designated S. Typhi, is the causative agent of typhoid fever. S. Typhi is a motile gram-negative enteric bacterium that is easily cultivated on standard bacteriologic media, although enrichment and selective media may be required for isolation of this organism from clinical materials. Occupational Infections Typhoid fever is a demonstrated hazard to laboratory personnel. 4,129,130 Ingestion and less frequently, parenteral inoculation are the most significant modes of transmission in the laboratory. Secondary transmission to other individuals outside of the laboratory is also a concern. 131 Laboratory-acquired S. Typhi infections usually present with symptoms of septicemia, headache, abdominal pain, and high fever. 129 Natural Modes of Infection Typhoid fever is a serious, potentially lethal bloodstream infection of worldwide distribution. Humans are the sole reservoir and asymptomatic carriers may occur. The infectious dose is low (
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Biosafety in Microbiological and Bi
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SECTION VIII-H: Prion Diseases 299
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Forward Biosafety in Microbiologica
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Editors: L. Casey Chosewood, MD Dir
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Guest Editors: Matthew J. Arduino,
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Charles B. Millard, PhD Lieutenant
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Robert Bull Karen B. Byers Jane Cap
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Thomas L. Miller Douglas M. Moore M
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Robert Yarchoan Uri Yokel Lisa Youn
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Introduction laboratories chose not
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Introduction RISK CRITERIA FOR ESTA
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Introduction BMBL includes an impor
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Section II Biological Risk Assessme
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Biological Risk Assessment informat
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Biological Risk Assessment The NIH
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Biological Risk Assessment effectiv
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Biological Risk Assessment Third, m
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Biological Risk Assessment 14. Oxma
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Principles of Biosafety Safety equi
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Principles of Biosafety Often an in
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Principles of Biosafety Four standa
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Principles of Biosafety 4. Centers
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Laboratory Biosafety Level Criteria
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Section V Vertebrate Animal Biosafe
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Vertebrate Animal Biosafety Level C
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Page 115 and 116: Vertebrate Animal Biosafety Level C
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Agent Summary Statements - Viral Ag
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Agent Summary Statements - Arboviru
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• Section VIII-G: Toxin Agents Se
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Agent Summary Statements - Toxins A
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• Section VIII-H: Prion Diseases
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Agent Summary Statement - Prion Dis
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Appendix A Proper maintenance of ca
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Appendix A declined. However, in ma
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Appendix A It is possible to exhaus
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Appendix A 4. The Class II, Type A2
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Appendix A prohibited. Furthermore,
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Appendix A plastic wrappers, pipett
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Appendix A touch-plate microburners
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Appendix A SECTION VI FACILITY AND
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Appendix A Development of Containme
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Appendix A C. Airflow Smoke Pattern
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Appendix A TABLES Table 1. Selectio
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Appendix A Table 3. Field Performan
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Appendix A FIGURES Figure 1. HEPA f
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Appendix A Figure 3. The Class II,
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Appendix A Figure 5B. The Class II,
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Appendix A Figure 8. The Class III
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Appendix A Figure 9B. The vertical
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Appendix A Figure 11. A typical lay
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Appendix A REFERENCES 1. Centers fo
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Appendix B Decontamination and Disi
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Appendix B surfaces are contaminate
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Appendix B TABLE 1 DESCENDING ORDER
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Appendix B dioxide gas exits the ge
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Appendix B d The effectiveness of a
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Appendix C Transportation of Infect
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Appendix C 1600 Clifton Road, N.E.,
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Appendix C disease in humans or in
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Appendix C Biological specimen, Cat
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Appendix D Agriculture Pathogen Bio
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Appendix D simultaneous opening of
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Appendix D 14. Pathological inciner
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Appendix D Wastes and other materia
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Appendix D Camelpox virus b a, b, c
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Appendix D SPECIAL ISSUES The impor
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Appendix D required by the USDA and
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Appendix D depression, anorexia, an
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Appendix D laboratory with enhancem
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Appendix D five day period of conta
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Appendix D slaughterhouses or indus
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Appendix D virus does not cause any
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Appendix D NDV is classified in the
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Appendix D movement permit is requi
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Appendix D Spring Viremia of Carp V
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Appendix D REFERENCES 1. Hess WR. A
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Appendix D 37. Alexander DJ. Newcas
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Appendix E Arthropod Containment Gu
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Appendix F Select Agents and Toxins
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Appendix G IPM issues and requireme
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Appendix H Working with Human, NHP
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Appendix I Guidelines for Work with
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decontaminated periodically, for ex
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0.25N, and/or sodium hypochlorite (
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k Irradiation causes a dose-depende
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7. Morin R, Kozlovac J. Biological
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Appendix J NIH Oversight of Researc
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Appendix K Resources for Informatio
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Appendix K E-mail: http://www2.gsu.
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Appendix K and http://www.who.int/c
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Appendix L HEPA High Efficiency Par
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