credits bmbl December 7 '06.doc - Central Michigan University

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Appendix G Preventive applications of pesticides should be discouraged, and treatments should be restricted to areas of known pest activity. When pesticides are applied, the least toxic product(s) available should be used and applied in the most effective and safe manner. Program Evaluation and Quality Assurance Quality assurance and program review should be performed to provide an objective, ongoing evaluation of IPM activities and effectiveness to ensure that the program does, in fact, control pests and meet the specific needs of the facility program(s) and its occupants. Based upon this review, current IPM protocols can be modified and new procedures implemented. Technical Expertise A qualified entomologist can provide helpful technical guidance to develop and implement an IPM program. Pest management personnel should be licensed and certified by the appropriate regulatory agency. Safety IPM minimizes the potential of pesticide exposure to the research environment and the staff by limiting the scope of pesticide treatments. REFERENCES 1. Robinson WH. Urban entomology: insect and mite pests in the human environment. New York: Chapman and Hall; 1996. 2. Bennett GW, Owens JM, editors. Advances in urban pest management. New York: Van Nostrand Reinhold Company; 1986. 3. Olkowski W, Daar S, Olkowski H. Common sense pest control: least-toxic solutions for your home, garden, pests and community. Newton (CT): The Taunton Press, Inc.; 1991. 4. National Pest Control Association [http://www.pestworld.org]. Fairfax (VA): The Association; [cited 2006 Sept 25]. Available from: http://www.pestworld.org. 5. Biocontrol Network [http://www.biconet.com]. Brentwood (TN): Biocontrol Network; c1995-2006 [updated 2006 Sept; cited 2006 Sept 25]. Available from: http://www.biconet.com. 402
Appendix H Working with Human, NHP and Other Mammalian Cells and Tissues Although risk of laboratory infection from working with cell cultures in general is low, risk increases when working with human and other primate cells, and primary cells from other mammalian species. There are reports of infection of laboratory workers handling primary rhesus monkey kidney cells, 1 and the bloodborne pathogen risks from working with primary human cells, tissues and body fluids are widely recognized. 2,3 OSHA has developed a bloodborne pathogens standard that should be applied to all work in the laboratory with human blood, tissues, body fluids and primary cell lines. 4 Procedures have also been published to reduce contamination of cell cultures with microorganisms. 5,6 Potential Laboratory Hazards Potential laboratory hazards associated with human cells and tissues include the bloodborne pathogens HBV, HIV, HCV, HTLV, EPV, HPV and CMV as well as agents such as Mycobacterium tuberculosis that may be present in human lung tissue. Other primate cells and tissues also present risks to laboratory workers. 7 Cells immortalized with viral agents such as SV-40, EBV adenovirus or HPV, as well as cells carrying viral genomic material also present potential hazards to laboratory workers. Tumorigenic human cells also are potential hazards as a result of self-inoculation. 8 There has been one reported case of development of a tumor from an accidental needle-stick. 9 Laboratory workers should never handle autologous cells or tissues. 1 NHP cells, blood, lymphoid and neural tissues should always be considered potentially hazardous. Recommended Practices Each institution should conduct a risk assessment based on the origin of the cells or tissues (species and tissue type), as well as the source (recently isolated or wellcharacterized). Human and other primate cells should be handled using BSL-2 practices and containment. All work should be performed in a BSC, and all material decontaminated by autoclaving or disinfection before discarding. 6,10,11,12 BSL-2 recommendations for personnel protective equipment such as laboratory coats, gloves and eye protection should be rigorously followed. All laboratory staff working with human cells and tissues should be enrolled in an occupational medicine program specific for bloodborne pathogens and should work under the policies and guidelines established by the institution’s Exposure Control Plan. 4 Laboratory staff working with human cells and tissues should provide a baseline serum sample, be offered hepatitis B immunization, and be evaluated by a health care professional following an exposure incident. Similar programs should be considered for work with NHP blood, body fluids, and other tissues. 403
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Biosafety in Microbiological and Bi
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SECTION VIII-H: Prion Diseases 299
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Forward Biosafety in Microbiologica
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Editors: L. Casey Chosewood, MD Dir
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Guest Editors: Matthew J. Arduino,
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Charles B. Millard, PhD Lieutenant
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Robert Bull Karen B. Byers Jane Cap
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Thomas L. Miller Douglas M. Moore M
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Robert Yarchoan Uri Yokel Lisa Youn
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Introduction laboratories chose not
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Introduction RISK CRITERIA FOR ESTA
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Introduction BMBL includes an impor
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Section II Biological Risk Assessme
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Biological Risk Assessment informat
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Biological Risk Assessment The NIH
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Biological Risk Assessment effectiv
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Biological Risk Assessment Third, m
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Biological Risk Assessment 14. Oxma
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Principles of Biosafety Safety equi
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Principles of Biosafety Often an in
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Principles of Biosafety Four standa
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Principles of Biosafety 4. Centers
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Laboratory Biosafety Level Criteria
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Section V Vertebrate Animal Biosafe
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Vertebrate Animal Biosafety Level C
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TABLE 1 SUMMARY OF RECOMMENDED BIOS
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Principles of Laboratory Biosecurit
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Occupational Health and Immunoproph
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Agent Summary Statements - Bacteria
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• Section VIII-B: Fungal Agents A
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Agent Summary Statements - Fungal A
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• Section VIII-C: Parasitic Agent
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Agent Summary Statements - Parasiti
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• Section VIII-D: Rickettsial Age
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Agent Summary Statements - Ricketts
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Agent Summary Statements - Ricketts
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• Section VIII-E: Viral Agents Ag
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Agent Summary Statements - Viral Ag
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• Section VIII-G: Toxin Agents Se
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Agent Summary Statements - Toxins i
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Agent Summary Statements - Toxins A
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• Section VIII-H: Prion Diseases
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Appendix A Proper maintenance of ca
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Appendix A declined. However, in ma
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Appendix A It is possible to exhaus
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Appendix A 4. The Class II, Type A2
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Appendix A prohibited. Furthermore,
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Appendix A plastic wrappers, pipett
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Appendix A touch-plate microburners
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Appendix A SECTION VI FACILITY AND
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Appendix A Development of Containme
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Appendix A C. Airflow Smoke Pattern
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Appendix A TABLES Table 1. Selectio
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Appendix A Table 3. Field Performan
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Appendix A FIGURES Figure 1. HEPA f
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Appendix A Figure 3. The Class II,
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Appendix A Figure 5B. The Class II,
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Appendix A Figure 8. The Class III
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Appendix A Figure 9B. The vertical
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Appendix A Figure 11. A typical lay
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Appendix A REFERENCES 1. Centers fo
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Appendix B Decontamination and Disi
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Appendix B surfaces are contaminate
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Appendix B TABLE 1 DESCENDING ORDER
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Page 355 and 356: Appendix C Transportation of Infect
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Page 363 and 364: Appendix D Agriculture Pathogen Bio
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Page 369 and 370: Appendix D Wastes and other materia
Page 371 and 372: Appendix D Camelpox virus b a, b, c
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Page 391 and 392: Appendix D Spring Viremia of Carp V
Page 393 and 394: Appendix D REFERENCES 1. Hess WR. A
Page 395 and 396: Appendix D 37. Alexander DJ. Newcas
Page 397 and 398: Appendix E Arthropod Containment Gu
Page 399 and 400: Appendix F Select Agents and Toxins
Page 401: Appendix G IPM issues and requireme
Page 405 and 406: Appendix I Guidelines for Work with
Page 407 and 408: decontaminated periodically, for ex
Page 409 and 410: 0.25N, and/or sodium hypochlorite (
Page 411 and 412: k Irradiation causes a dose-depende
Page 413 and 414: 7. Morin R, Kozlovac J. Biological
Page 415 and 416: Appendix J NIH Oversight of Researc
Page 417 and 418: Appendix K Resources for Informatio
Page 419 and 420: Appendix K E-mail: http://www2.gsu.
Page 421 and 422: Appendix K and http://www.who.int/c
Page 423 and 424: Appendix L HEPA High Efficiency Par
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