credits bmbl December 7 '06.doc - Central Michigan University

More documents

Recommendations

Info

Appendix D isolated from stillborn piglets from a single outbreak of reproductive disease in a commercial swine operation in New South Wales, Australia in 1997. Occupational Infections There was serological evidence of MenV infection in two people that had close contact with infected pigs on the affected premises. They demonstrated clinical signs similar to those seen with influenza such as chills, fever, drenching sweats, headache and rash. Both workers recovered fully from their illness. LABORATORY SAFETY Laboratory practices for MenV are principally designed to prevent transmission to susceptible livestock, but also to protect workers. The greatest risk of working with MenV is the escape of the organism into susceptible animal populations, which would necessitate USDA emergency procedures to contain and eradicate the disease. Containment Recommendations MenV is considered cause of a foreign animal disease in the United States and is a human pathogen. Due to the severe economic consequences of disease presence in the United States, this organism should only be handled in vitro in a BSL-3 laboratory with enhancements as required by the USDA and in vivo in a USDA-approved ABSL-3 animal facility with enhancements. SPECIAL ISSUES The importation, possession, or use of this agent is prohibited or restricted by law or by USDA regulations or administrative policies. A USDA/APHIS import or interstate movement permit is required to obtain this agent or any livestock or poultry product, such as blood, serum, or other tissues containing the agent. Newcastle Disease (ND) Virus ND is one of the most serious infectious diseases of poultry worldwide. It is primarily a respiratory disease, but nervous and enteric forms occur. All bird species are probably susceptible to infection with ND virus (NDV). The severity of the disease caused by any given NDV strain can vary from an unapparent infection to 100% mortality. The chicken is the most susceptible species. The bio-containment requirements for working with a particular strain are based on the virulence of the virus as determined by chicken inoculation and more recently by determination of amino acid sequence of the fusion protein cleavage site (as defined by the World Organization for Animal Health). 35 The virus is shed in respiratory secretions and in feces. Natural transmission among birds occurs by aerosol inhalation or by consumption of contaminated feed or water. 36,37 386
Appendix D NDV is classified in the Avulavirus genus within the family Paramyxoviridae, subfamily Paramyxovirinae, in the order Mononegavirales. All NDV isolates are of a single serotype avian paramyxovirus type 1 (APMV-1) that includes the antigenic variants isolated from pigeons called pigeon paramyxovirus 1. All strains are readily propagated in embryonated chicken eggs and a variety of avian and mammalian cell cultures although special additives may be required to propagate the low virulence (lentogenic) viruses in some cell types. 35-37 Occupational Infections The most common infection is a self-limiting conjunctivitis with tearing and pain that develops within 24 hours of an eye exposure by aerosol, splash of infective fluids, or eye contact with contaminated hands. The occurrence of upper respiratory or generalized symptoms is rare. 38 LABORATORY SAFETY NDV isolates may be recovered from any infected bird, but on occasion may be recovered from humans infected by contact with infected poultry. Humans treated with live NDV in experimental cancer therapies, or those who are exposed by laboratory contamination also are sources of the virus. 38 The greatest risk is for susceptible birds that may be exposed to NDV. If isolates of moderate to high virulence for chickens are used for human cancer therapies, those isolates are probably of greater risk for inadvertent exposure of birds and poultry than they are to the humans handling or being treated with those viruses. Containment Recommendations ND (produced by moderate or highly virulent forms of the virus) is considered a foreign animal disease in the United States. Due to the highly contagious nature of the agent and the severe economic consequences of disease presence in the United States, this organism should only be handled in vitro in a BSL-3 laboratory with enhancements as required by the USDA and in vivo in a USDA-approved BSL-3-Ag animal facility. Laboratory workers should have no contact with susceptible hosts for five days after working with the agent. Laboratory and animal studies with low virulence viruses or diagnostic accessions should be handled at BSL-2. SPECIAL ISSUES Velogenic strains of NDV are USDA Select Agents. Possession, transfer and use of this agent requires application of procedures as detailed in 9CFR Part 121, Agricultural Bioterrorism Protection Act of 2002; Possession, Use and Transfer of Biological Agents and Toxins. All rules concerning the possession, storage, use, and transfer of select agents apply. Please review Appendix F of this document for further instructions regarding Select Agents. An importation or interstate movement permit for NDV must be obtained from USDA/APHIS/VS. 387
Page 1 and 2:
Biosafety in Microbiological and Bi
Page 3 and 4:
SECTION VIII-H: Prion Diseases 299
Page 5 and 6:
Forward Biosafety in Microbiologica
Page 7 and 8:
Editors: L. Casey Chosewood, MD Dir
Page 9 and 10:
Guest Editors: Matthew J. Arduino,
Page 11 and 12:
Charles B. Millard, PhD Lieutenant
Page 13 and 14:
Robert Bull Karen B. Byers Jane Cap
Page 15 and 16:
Thomas L. Miller Douglas M. Moore M
Page 17 and 18:
Robert Yarchoan Uri Yokel Lisa Youn
Page 19 and 20:
Introduction laboratories chose not
Page 21 and 22:
Introduction RISK CRITERIA FOR ESTA
Page 23 and 24:
Introduction BMBL includes an impor
Page 25 and 26:
Section II Biological Risk Assessme
Page 27 and 28:
Biological Risk Assessment informat
Page 29 and 30:
Biological Risk Assessment The NIH
Page 31 and 32:
Biological Risk Assessment effectiv
Page 33 and 34:
Biological Risk Assessment Third, m
Page 35 and 36:
Biological Risk Assessment 14. Oxma
Page 37 and 38:
Principles of Biosafety Safety equi
Page 39 and 40:
Principles of Biosafety Often an in
Page 41 and 42:
Principles of Biosafety Four standa
Page 43 and 44:
Principles of Biosafety 4. Centers
Page 45 and 46:
Laboratory Biosafety Level Criteria
Page 47 and 48:
Page 49 and 50:
Page 51 and 52:
Page 53 and 54:
Page 55 and 56:
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
Page 75 and 76:
Section V Vertebrate Animal Biosafe
Page 77 and 78:
Vertebrate Animal Biosafety Level C
Page 79 and 80:
Page 81 and 82:
Page 83 and 84:
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
Page 93 and 94:
Page 95 and 96:
Page 97 and 98:
Page 99 and 100:
Page 101 and 102:
Page 103 and 104:
Page 105 and 106:
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
TABLE 1 SUMMARY OF RECOMMENDED BIOS
Page 121 and 122:
Principles of Laboratory Biosecurit
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Page 129 and 130:
Page 131 and 132:
Occupational Health and Immunoproph
Page 134 and 135:
Page 137 and 138:
Page 139 and 140:
Agent Summary Statements - Bacteria
Page 141 and 142:
Page 143 and 144:
Page 145 and 146:
Page 147 and 148:
Page 149 and 150:
Page 151 and 152:
Page 153 and 154:
Page 155 and 156:
Page 157 and 158:
Page 159 and 160:
Page 161 and 162:
Page 163 and 164:
Page 165 and 166:
Page 167 and 168:
Page 169 and 170:
Page 171 and 172:
Page 173 and 174:
Page 175 and 176:
Page 177 and 178:
Page 179 and 180:
Page 181 and 182:
Page 183 and 184:
Page 185 and 186:
• Section VIII-B: Fungal Agents A
Page 187 and 188:
Agent Summary Statements - Fungal A
Page 189 and 190:
Page 191 and 192:
Page 193 and 194:
Page 195 and 196:
Page 197 and 198:
• Section VIII-C: Parasitic Agent
Page 199 and 200:
Agent Summary Statements - Parasiti
Page 201 and 202:
Page 203 and 204:
Page 205 and 206:
Page 207 and 208:
Page 209 and 210:
• Section VIII-D: Rickettsial Age
Page 211 and 212:
Agent Summary Statements - Ricketts
Page 213 and 214:
Agent Summary Statements - Ricketts
Page 215 and 216:
• Section VIII-E: Viral Agents Ag
Page 217 and 218:
Agent Summary Statements - Viral Ag
Page 219 and 220:
Page 221 and 222:
Page 223 and 224:
Page 225 and 226:
Page 227 and 228:
Page 229 and 230:
Page 231 and 232:
Page 233 and 234:
Page 235 and 236:
Page 237 and 238:
Page 239 and 240:
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Agent Summary Statements - Arboviru
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
• Section VIII-G: Toxin Agents Se
Page 287 and 288:
Agent Summary Statements - Toxins i
Page 289 and 290:
Agent Summary Statements - Toxins A
Page 291 and 292:
Agent Summary Statements - Toxins L
Page 293 and 294:
Agent Summary Statements - Toxins e
Page 295 and 296:
Agent Summary Statements - Toxins o
Page 297 and 298:
Agent Summary Statements - Toxins t
Page 299 and 300:
• Section VIII-H: Prion Diseases
Page 301 and 302:
Agent Summary Statement - Prion Dis
Page 303 and 304:
Page 305 and 306:
Page 307 and 308:
Appendix A Proper maintenance of ca
Page 309 and 310:
Appendix A declined. However, in ma
Page 311 and 312:
Appendix A It is possible to exhaus
Page 313 and 314:
Appendix A 4. The Class II, Type A2
Page 315 and 316:
Appendix A prohibited. Furthermore,
Page 317 and 318:
Appendix A plastic wrappers, pipett
Page 319 and 320:
Appendix A touch-plate microburners
Page 321 and 322:
Appendix A SECTION VI FACILITY AND
Page 323 and 324:
Appendix A Development of Containme
Page 325 and 326:
Appendix A C. Airflow Smoke Pattern
Page 327 and 328:
Appendix A TABLES Table 1. Selectio
Page 329 and 330:
Appendix A Table 3. Field Performan
Page 331 and 332:
Appendix A FIGURES Figure 1. HEPA f
Page 333 and 334:
Appendix A Figure 3. The Class II,
Page 335 and 336: Appendix A Figure 5B. The Class II,
Page 337 and 338: Appendix A Figure 8. The Class III
Page 339 and 340: Appendix A Figure 9B. The vertical
Page 341 and 342: Appendix A Figure 11. A typical lay
Page 343 and 344: Appendix A REFERENCES 1. Centers fo
Page 345 and 346: Appendix B Decontamination and Disi
Page 347 and 348: Appendix B surfaces are contaminate
Page 349 and 350: Appendix B TABLE 1 DESCENDING ORDER
Page 351 and 352: Appendix B dioxide gas exits the ge
Page 353 and 354: Appendix B d The effectiveness of a
Page 355 and 356: Appendix C Transportation of Infect
Page 357 and 358: Appendix C 1600 Clifton Road, N.E.,
Page 359 and 360: Appendix C disease in humans or in
Page 361 and 362: Appendix C Biological specimen, Cat
Page 363 and 364: Appendix D Agriculture Pathogen Bio
Page 365 and 366: Appendix D simultaneous opening of
Page 367 and 368: Appendix D 14. Pathological inciner
Page 369 and 370: Appendix D Wastes and other materia
Page 371 and 372: Appendix D Camelpox virus b a, b, c
Page 373 and 374: Appendix D SPECIAL ISSUES The impor
Page 375 and 376: Appendix D required by the USDA and
Page 377 and 378: Appendix D depression, anorexia, an
Page 379 and 380: Appendix D laboratory with enhancem
Page 381 and 382: Appendix D five day period of conta
Page 383 and 384: Appendix D slaughterhouses or indus
Page 385: Appendix D virus does not cause any
Page 389 and 390: Appendix D movement permit is requi
Page 391 and 392: Appendix D Spring Viremia of Carp V
Page 393 and 394: Appendix D REFERENCES 1. Hess WR. A
Page 395 and 396: Appendix D 37. Alexander DJ. Newcas
Page 397 and 398: Appendix E Arthropod Containment Gu
Page 399 and 400: Appendix F Select Agents and Toxins
Page 401 and 402: Appendix G IPM issues and requireme
Page 403 and 404: Appendix H Working with Human, NHP
Page 405 and 406: Appendix I Guidelines for Work with
Page 407 and 408: decontaminated periodically, for ex
Page 409 and 410: 0.25N, and/or sodium hypochlorite (
Page 411 and 412: k Irradiation causes a dose-depende
Page 413 and 414: 7. Morin R, Kozlovac J. Biological
Page 415 and 416: Appendix J NIH Oversight of Researc
Page 417 and 418: Appendix K Resources for Informatio
Page 419 and 420: Appendix K E-mail: http://www2.gsu.
Page 421 and 422: Appendix K and http://www.who.int/c
Page 423 and 424: Appendix L HEPA High Efficiency Par
show all

credits bmbl December 7 '06.doc - Central Michigan University

Create successful ePaper yourself

Delete template?

Save as template?