credits bmbl December 7 '06.doc - Central Michigan University

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Appendix B 8. Tearle P. Decontamination by fumigation. Commun Dis Public Health. 2003;6:166-8. 9. Fink R, Liberman DF, Murphy K, et al. Biological safety cabinets, decontamination or sterilization with paraformaldehyde. Am Ind Hyg Assoc J. 1988;49:277-9. 10. Klapes NA, Vesley D. Vapor-phase hydrogen peroxide as a surface decontaminant and sterilant. Appl Environ Microbiol. 1990;56:503-6. 11. Graham GS, Rickloff JR. Development of VHP sterilization technology. J Healthc Mater Manage. 1992;54:56-8. 12. Johnson JW, Arnold JF, Nail SL, et al. Vaporized hydrogen peroxide sterilization of freeze dryers. J Parenter Sci Technol. 1992;46:215-25. 13. Heckert RA, Best M, Jordan LT, et al. Efficacy of vaporized hydrogen peroxide against exotic animal viruses. Appl Environ Microbiol. 1997;63:3916-8. 14. Krause J, McDonnell G, Riedesel H. Biodecontamination of animal rooms and heat-sensitive equipment with vaporized hydrogen peroxide. Contemp Top Lab Anim Sci. 2001;40:18-21. 15. Knapp JE, Battisti DL. Chlorine Dioxide. In: Block S, editor. Disinfection, sterilization, and preservation. 5th ed. Philadelphia: Lippencott, Williams and Wilkens; 2001. p. 215-27. 16. Weber DJ, Rutala WA. Occupational risks associated with the use of selected disinfectants and sterilants. In: Rutala WA, editor. Disinfection, sterilization and antisepsis in health care. Champlain (NY): Polyscience Publications: 1998 p. 211- 26. 354
Appendix C Transportation of Infectious Substances An infectious substance is a material known to contain or reasonably expected to contain a pathogen. A pathogen is a microorganism (including bacteria, viruses, rickettsiae, parasites, fungi) or other agent, such as a proteinaceous infectious particle (prion), that can cause disease in humans or animals. Infectious substances may exist as purified and concentrated cultures, but may also be present in a variety of materials, such as body fluids or tissues. Transportation of infectious substances and materials that are known or suspected to contain them are regulated as hazardous materials by the United State Department of Transportation (DOT), foreign governments, and the International Civil Aviation Organization, and their transportation is subject to regulatory controls. For transport purposes, the term “infectious substance” is understood to include the term “etiologic agent.” TRANSPORTATION REGULATIONS International and domestic transport regulations for infectious substances are designed to prevent the release of these materials in transit to protect the public, workers, property, and the environment from the harmful effects that may occur from exposure to these materials. Protection is achieved through rigorous packaging requirements and hazard communication. Packages must be designed to withstand rough handling and other forces experienced in transportation, such as changes in air pressure and temperature, vibration, stacking, and moisture. Hazard communication includes shipping papers, labels, markings on the outside of packagings, and other information necessary to enable transport workers and emergency response personnel to correctly identify the material and respond efficiently in an emergency situation. In addition, shippers and carriers must be trained on these regulations so they can properly prepare shipments and recognize and respond to the risks posed by these materials. Select agents include infectious substances that have been identified by the CDC and the USDA as having the potential to pose a severe threat to public health and safety. Persons who offer for transportation or transport select agents in commerce in the United States must develop and implement security plans for such transportation. A security plan must include an assessment of the possible transportation security risks for materials covered by the security plan and specific measures to reduce or eliminate the assessed risks. At a minimum, a security plan must include measures to address those risks associated with personnel security, en route security, and unauthorized access. REGULATIONS Department of Transportation. 49 CFR Part 171-180, Hazardous Materials Regulations. Applies to the shipment of infectious substances in commercial transportation within the United States. Information on these regulations may be obtained at the Internet website: http://hazmat.dot.gov. 355
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Biosafety in Microbiological and Bi
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SECTION VIII-H: Prion Diseases 299
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Forward Biosafety in Microbiologica
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Editors: L. Casey Chosewood, MD Dir
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Guest Editors: Matthew J. Arduino,
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Charles B. Millard, PhD Lieutenant
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Robert Bull Karen B. Byers Jane Cap
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Thomas L. Miller Douglas M. Moore M
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Robert Yarchoan Uri Yokel Lisa Youn
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Introduction laboratories chose not
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Introduction RISK CRITERIA FOR ESTA
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Introduction BMBL includes an impor
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Section II Biological Risk Assessme
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Biological Risk Assessment informat
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Biological Risk Assessment The NIH
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Biological Risk Assessment effectiv
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Biological Risk Assessment Third, m
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Biological Risk Assessment 14. Oxma
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Principles of Biosafety Safety equi
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Principles of Biosafety Often an in
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Principles of Biosafety Four standa
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Principles of Biosafety 4. Centers
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Laboratory Biosafety Level Criteria
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Section V Vertebrate Animal Biosafe
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Vertebrate Animal Biosafety Level C
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TABLE 1 SUMMARY OF RECOMMENDED BIOS
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Principles of Laboratory Biosecurit
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Occupational Health and Immunoproph
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Agent Summary Statements - Bacteria
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• Section VIII-B: Fungal Agents A
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• Section VIII-C: Parasitic Agent
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Agent Summary Statements - Parasiti
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• Section VIII-D: Rickettsial Age
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Agent Summary Statements - Ricketts
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Agent Summary Statements - Ricketts
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• Section VIII-E: Viral Agents Ag
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Agent Summary Statements - Viral Ag
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Agent Summary Statements - Toxins A
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• Section VIII-H: Prion Diseases
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Agent Summary Statement - Prion Dis
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Page 307 and 308: Appendix A Proper maintenance of ca
Page 309 and 310: Appendix A declined. However, in ma
Page 311 and 312: Appendix A It is possible to exhaus
Page 313 and 314: Appendix A 4. The Class II, Type A2
Page 315 and 316: Appendix A prohibited. Furthermore,
Page 317 and 318: Appendix A plastic wrappers, pipett
Page 319 and 320: Appendix A touch-plate microburners
Page 321 and 322: Appendix A SECTION VI FACILITY AND
Page 323 and 324: Appendix A Development of Containme
Page 325 and 326: Appendix A C. Airflow Smoke Pattern
Page 327 and 328: Appendix A TABLES Table 1. Selectio
Page 329 and 330: Appendix A Table 3. Field Performan
Page 331 and 332: Appendix A FIGURES Figure 1. HEPA f
Page 333 and 334: Appendix A Figure 3. The Class II,
Page 335 and 336: Appendix A Figure 5B. The Class II,
Page 337 and 338: Appendix A Figure 8. The Class III
Page 339 and 340: Appendix A Figure 9B. The vertical
Page 341 and 342: Appendix A Figure 11. A typical lay
Page 343 and 344: Appendix A REFERENCES 1. Centers fo
Page 345 and 346: Appendix B Decontamination and Disi
Page 347 and 348: Appendix B surfaces are contaminate
Page 349 and 350: Appendix B TABLE 1 DESCENDING ORDER
Page 351 and 352: Appendix B dioxide gas exits the ge
Page 353: Appendix B d The effectiveness of a
Page 357 and 358: Appendix C 1600 Clifton Road, N.E.,
Page 359 and 360: Appendix C disease in humans or in
Page 361 and 362: Appendix C Biological specimen, Cat
Page 363 and 364: Appendix D Agriculture Pathogen Bio
Page 365 and 366: Appendix D simultaneous opening of
Page 367 and 368: Appendix D 14. Pathological inciner
Page 369 and 370: Appendix D Wastes and other materia
Page 371 and 372: Appendix D Camelpox virus b a, b, c
Page 373 and 374: Appendix D SPECIAL ISSUES The impor
Page 375 and 376: Appendix D required by the USDA and
Page 377 and 378: Appendix D depression, anorexia, an
Page 379 and 380: Appendix D laboratory with enhancem
Page 381 and 382: Appendix D five day period of conta
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Page 387 and 388: Appendix D NDV is classified in the
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Page 391 and 392: Appendix D Spring Viremia of Carp V
Page 393 and 394: Appendix D REFERENCES 1. Hess WR. A
Page 395 and 396: Appendix D 37. Alexander DJ. Newcas
Page 397 and 398: Appendix E Arthropod Containment Gu
Page 399 and 400: Appendix F Select Agents and Toxins
Page 401 and 402: Appendix G IPM issues and requireme
Page 403 and 404: Appendix H Working with Human, NHP
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Appendix I Guidelines for Work with
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decontaminated periodically, for ex
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0.25N, and/or sodium hypochlorite (
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k Irradiation causes a dose-depende
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7. Morin R, Kozlovac J. Biological
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Appendix J NIH Oversight of Researc
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Appendix K Resources for Informatio
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Appendix K E-mail: http://www2.gsu.
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Appendix K and http://www.who.int/c
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Appendix L HEPA High Efficiency Par
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