credits bmbl December 7 '06.doc - Central Michigan University

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• Section VIII-F: Arboviruses and Related Zoonotic Viruses In 1979, the American Committee on Arthropod-Borne Viruses (ACAV) Subcommittee on Arbovirus Laboratory Safety (SALS) first provided biosafety recommendations for each of the 424 viruses then registered in the International Catalogue of Arboviruses, including Certain Other Viruses of Vertebrates. 1 Working together, SALS, the CDC and the NIH have periodically updated the catalogue by providing recommended biosafety practices and containment for arboviruses registered since 1979. These recommendations are based, in part, on risk assessments derived from information provided by a worldwide survey of laboratories working with arboviruses, new published reports on the viruses, as well as discussions with scientists working with each virus. Table 1, located at the end of this section, provides an alphabetical listing of 597 viruses and includes common name, virus family or genus, acronym, BSL recommendation, the basis for the rating, the antigenic group 2 (if known), HEPA filtration requirements, and regulatory requirements (i.e. import/export permits from either the CDC or the USDA). In addition, many of the organisms are classified as Select Agents and require special security measures to possess, use, or transport (See Appendix F). Table 2 provides a key for the SALS basis for assignment of viruses listed in Table 1. Agent summary statements have been included for certain arboviruses. They were submitted by a panel of experts for more detailed consideration due to one or more of the following factors: • at the time of writing this edition the organism represented an emerging public health threat in the United States; • the organism presented unique biocontainment challenge(s) that required further detail; • the organism presented a significant risk of laboratory-acquired infection. These recommendations were made in August 2005; requirements for biosafety, shipping, and select agent registration can change. Please be sure to confirm the requirements with the appropriate Federal agency. If the pathogen of interest is one listed in Appendix D, contact the USDA for additional biosafety requirements. USDA guidance may supersede the information found in this chapter. Recommendations for the containment of infected arthropod vectors were drafted by a subcommittee of the American Committee on Medical Entomology (ACME), and circulated widely among medical entomology professionals (See Appendix E). 244
Agent Summary Statements – Arboviruses and Related Zoonotic Viruses Some commonly used vaccine strains for which attenuation has been firmly established are recognized by SALS. These vaccine strains may be handled safely at BSL-2 (Table 3). The agents in Table 2 may require permits from USDA/DOC/DHHS. 245
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Biosafety in Microbiological and Bi
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SECTION VIII-H: Prion Diseases 299
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Forward Biosafety in Microbiologica
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Editors: L. Casey Chosewood, MD Dir
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Guest Editors: Matthew J. Arduino,
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Charles B. Millard, PhD Lieutenant
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Robert Bull Karen B. Byers Jane Cap
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Thomas L. Miller Douglas M. Moore M
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Robert Yarchoan Uri Yokel Lisa Youn
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Introduction laboratories chose not
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Introduction RISK CRITERIA FOR ESTA
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Introduction BMBL includes an impor
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Section II Biological Risk Assessme
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Biological Risk Assessment informat
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Biological Risk Assessment The NIH
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Biological Risk Assessment effectiv
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Biological Risk Assessment Third, m
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Biological Risk Assessment 14. Oxma
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Principles of Biosafety Safety equi
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Principles of Biosafety Often an in
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Principles of Biosafety Four standa
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Principles of Biosafety 4. Centers
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Laboratory Biosafety Level Criteria
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Section V Vertebrate Animal Biosafe
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Vertebrate Animal Biosafety Level C
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TABLE 1 SUMMARY OF RECOMMENDED BIOS
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Principles of Laboratory Biosecurit
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Occupational Health and Immunoproph
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Agent Summary Statements - Bacteria
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• Section VIII-B: Fungal Agents A
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Agent Summary Statements - Fungal A
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• Section VIII-H: Prion Diseases
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Agent Summary Statement - Prion Dis
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Appendix A Proper maintenance of ca
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Appendix A declined. However, in ma
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Appendix A It is possible to exhaus
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Appendix A 4. The Class II, Type A2
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Appendix A prohibited. Furthermore,
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Appendix A plastic wrappers, pipett
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Appendix A touch-plate microburners
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Appendix A SECTION VI FACILITY AND
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Appendix A Development of Containme
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Appendix A C. Airflow Smoke Pattern
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Appendix A TABLES Table 1. Selectio
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Appendix A Table 3. Field Performan
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Appendix A FIGURES Figure 1. HEPA f
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Appendix A Figure 3. The Class II,
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Appendix A Figure 5B. The Class II,
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Appendix A Figure 8. The Class III
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Appendix A Figure 9B. The vertical
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Appendix A Figure 11. A typical lay
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Appendix A REFERENCES 1. Centers fo
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Appendix B Decontamination and Disi
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Appendix B surfaces are contaminate
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Appendix B TABLE 1 DESCENDING ORDER
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Appendix B dioxide gas exits the ge
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Appendix B d The effectiveness of a
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Appendix C Transportation of Infect
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Appendix C 1600 Clifton Road, N.E.,
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Appendix C disease in humans or in
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Appendix C Biological specimen, Cat
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Appendix D Agriculture Pathogen Bio
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Appendix D simultaneous opening of
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Appendix D 14. Pathological inciner
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Appendix D Wastes and other materia
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Appendix D Camelpox virus b a, b, c
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Appendix D SPECIAL ISSUES The impor
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Appendix D required by the USDA and
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Appendix D depression, anorexia, an
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Appendix D laboratory with enhancem
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Appendix D five day period of conta
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Appendix D slaughterhouses or indus
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Appendix D virus does not cause any
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Appendix D NDV is classified in the
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Appendix D movement permit is requi
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Appendix D Spring Viremia of Carp V
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Appendix D REFERENCES 1. Hess WR. A
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Appendix D 37. Alexander DJ. Newcas
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Appendix E Arthropod Containment Gu
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Appendix F Select Agents and Toxins
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Appendix G IPM issues and requireme
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Appendix H Working with Human, NHP
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Appendix I Guidelines for Work with
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decontaminated periodically, for ex
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0.25N, and/or sodium hypochlorite (
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k Irradiation causes a dose-depende
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7. Morin R, Kozlovac J. Biological
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Appendix J NIH Oversight of Researc
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Appendix K Resources for Informatio
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Appendix K E-mail: http://www2.gsu.
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Appendix K and http://www.who.int/c
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Appendix L HEPA High Efficiency Par
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