14th ICID - Poster Abstracts - International Society for Infectious ...

When citing these abstracts please use the following reference:
Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number.
Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1
is available electronically on http://www.sciencedirect.com
Final Abstract Number: 77.002
Session: Gram-positives & Miscellaneous Pathogens
Date: Friday, March 12, 2010
Time: 12:30-13:30
Room: Poster & Exhibition Area/Ground Level
Type: Poster Presentation
Thrombocytopenia in murine typhus: A study of 161 cases
S. DOUKAKIS 1 , M. PAPADAKIS 1 , M. DAOUKAKIS 1 , P. STAVROULAKIS 1 , K. BAMBILI 1 , G.
POLYMILI 1 , D. TRIANTAFILLIDOU 1 , M. JUNIE 1 , S. KASTANAKIS 2
1 CHANIA, Greece, 2 SAINT GEORGE GENERAL HOSPITAL CHANIA GREECE, CHANIA,
Greece
Background: According to the international literature thrombocytopenia is frequent in murine
typhus.
Methods: One hundred and sixty- one patients with compatible clinical status of murine typhus
and high serological titers of antibodies against Rickettsia typhi, were studied from our team,
during a period of time between January 1993 and December 2007. Three blood samples were
obtained from each patient for the study of their thrombocytopenia. The first sample was obtained
on admission, approximately 9 days after the onset of the disease. The second sample
approximately two weeks after the first. The third sample, taken from the one third of the patients,
was obtained one month after the second. On admission (first sample) 88/161 patients (54.6%)
presented thrombocytopenia and the median value of platelets was 141x103 /ml respectively.
Two weeks later (second sample) 23/147 patients (15.3%) presented thrombocytopenia. The
median value of platelets was 247x103 /ml respectively. One month later (third sample) 2/42
patients (4.8%) presented thrombocytopenia and the median value of platelets was 224.5x103
/ml respectively.
Results: Our study showed that thrombocytopenia is frequent in murine typhus on admission of
the patients to the hospitals. The number of platelets, according to our results, returns to normal
value after almost a month of the onset of the infection.
Conclusion: Thrombocytopenia returns to normal values after a month of the onset of the
infection.