14th ICID - Poster Abstracts - International Society for Infectious ...
14th ICID - Poster Abstracts - International Society for Infectious ...
14th ICID - Poster Abstracts - International Society for Infectious ...
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When citing these abstracts please use the following reference:<br />
Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number.<br />
Please note that the official publication of the <strong>International</strong> Journal of <strong>Infectious</strong> Diseases 2010, Volume 14, Supplement 1<br />
is available electronically on http://www.sciencedirect.com<br />
Final Abstract Number: 80.019<br />
Session: Pediatric and Perinatal Infections<br />
Date: Friday, March 12, 2010<br />
Time: 12:30-13:30<br />
Room: <strong>Poster</strong> & Exhibition Area/Ground Level<br />
Type: <strong>Poster</strong> Presentation<br />
RCT Methodology, population profile and pneumonia rates in socio-economically deprived infants<br />
of Kabul: Data from a RCT investigating the effects of vitamin D supplementation on the<br />
incidence of infant pneumonia<br />
Z. Zabihullah 1 , S. Manaseki-Holland 2 , D. Chandramohan 3 , Z. Bhutta 4 , Z. Mughal 5<br />
1 London School of Hygiene and Tropical Medicine, London, London, United Kingdom, 2 University<br />
of Birmingham, Birmingham, Birmingham, United Kingdom, 3 London School and Hygiene and<br />
Tropical Medicine, London, London, United Kingdom, 4 The Aga Khan University, Karachi,<br />
Pakistan, 5 Saint Mary's Hospital <strong>for</strong> Women and Children, Marchester, Manchester, United<br />
Kingdom<br />
Background:<br />
Approximately 150 million children under-5 suffer from pneumonia each year worldwide and<br />
South-east Asia has the highest incidence of pneumonia (0.36 episodes per child-year). Two<br />
hospital-based case-control studies from Ethiopia and India suggest that vitamin D deficiency<br />
may substantially increase the risk of severe pneumonia among children under-5. In Afghanistan<br />
Dietary intake of vitamin D is low and exposure to sunlight is also limited due to widespread use<br />
of Burqua. Thus it was hypothesized that supplementation of vitamin D would reduce the<br />
incidence of pneumonia in young children particularly in areas where vitamin D deficiency is<br />
common.<br />
Methods: Study Design: Double blind placebo controlled trial<br />
Setting: 4 urban districts in Kabul, Afghanistan with a socio-economically deprived population<br />
living in overcrowded housing.<br />
Subjects: 3048 children(half taking vitamin D and half placebo) aged 1-11 months at recruitment<br />
(Nov-Dec 2007) followed up <strong>for</strong> 18 months through active and passive surveillances.<br />
Intervention: 3-monthly oral 100,000IU vitamin D versus Placebo (olive oil).<br />
Analysis: Rate ratio <strong>for</strong> episodes of pneumonia was calculated <strong>for</strong> the whole population using<br />
survival analysis. Kaplan Meier plots display the survival curves. Covariates in the models control<br />
<strong>for</strong> potential confounders and/or interactions<br />
Results: Socio-demographic Profile Sex ratio of infants was balanced (males 52.2% and females<br />
47.8%).The mean age of children was 6.5 months (SD 3.1) at recruitment.<br />
Incidence rate of Clinical Pneumonia (IMCI definition): As the trial is not complete yet, the data <strong>for</strong><br />
the first 12 months is used <strong>for</strong> this presentation The incidence rate (95% CI) <strong>for</strong> first episode of<br />
simple pneumonia was 1.5/child year (1.5,1.6), while <strong>for</strong> repeat episodes was 1.7 (1.7,1.8). The<br />
incidence rate of the first episode of severe pneumonia was 0.1/child year (0.09, 0.12) and <strong>for</strong><br />
repeat episodes was 0.1 (0.11, 0.13). The incidence rate of all episodes of pneumonia was 1.8<br />
(1.7, 1.8).<br />
Conclusion: RCT with 18 months follow up amongst socio-economically deprived population in<br />
Kabul can be successfully implemented. Lessons learned will be shared in the presentation. The<br />
incidence rate <strong>for</strong> pneumonia seems high compared to South Asia rates