14th ICID - Poster Abstracts - International Society for Infectious ...
14th ICID - Poster Abstracts - International Society for Infectious ...
14th ICID - Poster Abstracts - International Society for Infectious ...
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When citing these abstracts please use the following reference:<br />
Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number.<br />
Please note that the official publication of the <strong>International</strong> Journal of <strong>Infectious</strong> Diseases 2010, Volume 14, Supplement 1<br />
is available electronically on http://www.sciencedirect.com<br />
Final Abstract Number: 84.026<br />
Session: Virology and Viral Infections (Non-HIV)<br />
Date: Friday, March 12, 2010<br />
Time: 12:30-13:30<br />
Room: <strong>Poster</strong> & Exhibition Area/Ground Level<br />
Type: <strong>Poster</strong> Presentation<br />
The role of human papillomavirus Infection in prostate carcinoma<br />
A. Aghakhani 1 , R. Hamkar 2 , M. Parvin 3 , M. Banifazl 4 , A. Eslamifar 1 , A. Ramezani 1<br />
1 Pasteur Institute of Iran, Tehran, Iran, Islamic Republic of, 2 Tehran University of Medical<br />
Sciences, Tehran, Iran, Islamic Republic of, 3 Shahid Beheshti University of Medical Sciences,<br />
Tehran, Iran, Islamic Republic of, 4 Iranian society <strong>for</strong> support patients with infectious diseases,<br />
Tehran, Iran, Islamic Republic of<br />
Background: Human papillomavirus (HPV) infections are frequently associated with benign, premalignant<br />
and malignant lesions of the female genital region and male anogenital tract. One<br />
potential etiological factor of interest <strong>for</strong> prostate carcinoma (PCa) in light of the associations with<br />
sexual practices is exposure to HPV. Currently the possible role of HPV infections in prostate<br />
carcinogenesis is a subject of great controversy. In this study we aimed to investigate the role of<br />
HPV infection in prostate carcinoma.<br />
Methods: Formalin-fixed and paraffin-embedded tissue samples of 104 primary prostate<br />
adenocarcinoma cases with varying degrees of differentiation and 104 control tissues of benign<br />
prostatic hyperplasia (BPH) were provided <strong>for</strong> analysis. HPV-DNA was purified and amplified<br />
through MY09/MY11 and GP5+/GP6+ primers and subsequently subjected to sequencing.<br />
Results: HPV-DNA was found in 11 of 104 (10.58%) PCa and 7 of 104 (6.73%) BPH samples.<br />
There was not any significant difference between PCa and BPH specimens regarding HPV-DNA<br />
presence. High-risk HPVs (type 16&18) were detected in all of the PCa and 6 of 7 (85.7%) BPH<br />
samples (not significant) and low-risk HPV (type11) were detected in none of the PCa and 1 of 7<br />
(14.2%) BPH specimens (not significant). HPV-16 was the predominant HPV type in both PCa<br />
and BPH samples.<br />
Conclusion: Our study showed that there was not any significant difference between PCa and<br />
BPH specimens regarding HPV-DNA presence. Our data do not support the hypothesis that HPV<br />
infection is related to the development of prostate cancer. However, as with other HPVassociated<br />
diseases, attributing a role to the virus in the etiology of prostatic carcinoma will<br />
require further detailed studies.
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