14th ICID - Poster Abstracts - International Society for Infectious ...

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When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 78.020 Session: HIV: Opportunistic Infections & Malignancies Date: Friday, March 12, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Human Papillomavirus (HPV) detection in urine of HIV-infected women I. Rosa-Cunha, J. Prewitt, T. Guettouche, T. Hooton University of Miami, Miami, Fl, USA Background: HIV-infected women are at higher risk of cervical HPV infection persistence and related malignancy and the incidence of cervical cancer is likely to increase along with patient survival. The importance of screening in this population is thus evident, but costs of providing pap exams are considerable, the test is less than 70% sensitive, and nearly 1 in 4 HIV-infected women do not receive an annual Pap test. We assessed the feasibility of using urine samples from HIV-infected women to screen for HPV infection and cervical disease. Methods: 18 HIV-infected women referred to HIV colposcopy clinic at Jackson Memorial Hospital, Miami, Fl, for further evaluation of abnormal cervical Pap smear results agreed to collect urine sample for HPV testing. Colposcopy clinic practioners performed colposcopic examination with biopsy of visible lesion(s) as per clinic routine. Participants self collected at least 15ml of urine. Presence of HPV in urine was evaluated using HPV Genotyping Microarray (Kurabo Industries Ltd, Osaka, Japan) with the capability to specifically identify 23 oncogenic HPV types. Results: 100% of the women approached accepted to participate in the study. Baseline cervical Pap smear results that triggered colposcopy referral were: 12 women (67%) with low grade squamous intraepithelial lesion and 6 (33%) with atypical cells of unknown significance (AS- CUS). Results for routine HPV testing using Hybrid Capture II assay (Digene Corp., Silver Spring, MD) were available for 12 participants with 9 samples (75%)being positive for HPV. Cervical biopsies were performed in 16 of the 18 patients referred to colposcopy; 13 patients had cervical intraepithelial neoplasia (CIN) I, 2 had CIN II and 1 had no abnormality. Urine HPV testing was positive in all but two patients; 46% of the samples were positive for multiple HPV oncogenic types; most isolated oncogenic HPV (71%) were non-16 and non-18 types. Conclusion: Preliminary analysis suggests that self-collected urine sample for HPV testing was well accepted by HIV-infected women and could potentially have a role as a screening method for HPV infection and cervical dysplasia in this population. More studies are needed to further evaluate the potential of urine HPV screening in HIV-infected women.
When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 79.001 Session: Obstetrical-Gynecological, Surgical and Sexually Transmitted Infections Date: Friday, March 12, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Prevalence of bacterial vaginosis amongst women of child bearing age E. O. Chima-Oduko, C.J. Uneke Ebonyi State University, Abuja, Nigeria Background: Bacterial vaginosis,previously known as non-specific vaginitis or Gardnerella vaginits,is the most common cause of vaginal discharge.It may be the cause of up to one half of cases of vaginitis in all women and the cause of from 10 to 30 percent of cases in pregnant women.The clinical syndrome is now recognized as a polymicrobial superficial vaginal infection involving a loss of the normal lactobacilli and an overgrowth of anaerobes. Bv has mostly been associated to sexual transmission,though some controversy remains.It occurs commonly in women with more than one sexual partners, and can also occur in women who are not yet sexually active.Recent studies have confirmed its association with pelvic inflammatory disease and adverse pregnancy outcome.The aim of the research was to determine the prevalence of Bv infection among women of child bearing age with the view of evaluating epidemiological factors and risk factors responsible for the infection among individuals within this category and identifying possible ideal control measures. Methods: In this cross-sectional study, 102 women of child bearing age ( comprising pregnant and non-pregnant) in selected hospitals and laboratory in Abakaliki and Afikpo, Ebonyi State, from December 2005 - march 2006, were screened to determine the prevalence of Bv among them, using three standard diagnostic technique (wet mount, whiff test and gram stain). A structured questionnaire was also administered to 23 subjects in order to obtain vital epidemiological information necessary for the study. Results: And to also link their laboratory result to the information and 16 (69.6%) tested positive. The data analysis was done using chi-square tests. Results show 49 (48.0%) were positive for wet mount, 58 (56.9%) for whiff test and 20 (23.5%) for gram stain. Age, douching, Use of IUD, and sexual activities of individual had no significant effect on prevalence of Bv, while symptomatology was a major indicator of infection. Conclusion: Risk factors associated with significant infection were linked to ignorance of women, gynaecologist and laboratory technicians of the existence of Bv resulting to non- diagnosis of Bv infection, wearing of tight panties and poor hygiene conditions as well. Since Bv could be asymptomatic, routine screening of women, visiting gynecology, fertility clinics and antenatal care are advocated.
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