14th ICID - Poster Abstracts - International Society for Infectious ...

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When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 77.008 Session: Gram-positives & Miscellaneous Pathogens Date: Friday, March 12, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Bacillus cereus bacteremia in hospital setting G. Ohji 1 , Y. Oba 1 , K. Takimoto 1 , H. Kagawa 1 , D. Uchida 1 , R. Suganaga 1 , H. Oka 1 , S. Kinoshita 2 , M. Nakamura 2 , H. Yoshida 2 , K. Iwata 1 1 Kobe University Graduate School of Medicine, Kobe, Japan, 2 Kobe University Hospital, Kobe, Japan Background: Since Bacillus cereus is rarely associated actual infections, single positive blood culture is often considered as contamination. However, it can cause number of nosocomial infections such as catheter-associated blood stream infection. We investigated the bacteremic patients to assess the clinical impact of this organism. Methods: We performed a retrospective analysis of bloodstream infections due to B. cereus at a tertiary care hospital in Kobe, Japan from October 2008 to September 2009. Cases were identified via microbiology laboratory reports, and relevant clinical data were collected from the electronic medical record of each patient. The case with at least 2 set positive blood cultures were defined as real infection. Results: Nine cases of catheter related blood stream infections (CRBSI) caused by B. cereus were identified. Only one case had the presence of an indwelling central venous catheter (CVC). Three cases (33%) were associated with previous antibiotic therapy. Two cases (2/9, 22%) were associated with solid organ malignancies whereas no case with hematological malignancy. One patient was on continuous hemodialysis. The most common characteristics (7/9, 77%) were the use of peripheral parenteral nutrition. These 7 cases had use of solutions containing 7.5% glucose and 3.0% amino acid. For 8 cases vancomycin was used with success. No patient died. All isolates were sensitive for vancomycin whereas resistant to beta-lactams. Two isolates were sensitive for clindamycin. Conclusion: Bacillus cereus can cause CRBSI. Indwelling CVC may not increase Bacillus cereus CRBSI whereas peripheral parenteral nutrition with higher amino acid concentration can be a risk factor. Vancomycin may be appropriate antibiotic for empiric therapy. Further studies are necessary to further determine the risk of Bacillus cereus infection.
When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 77.009 Session: Gram-positives & Miscellaneous Pathogens Date: Friday, March 12, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Prognostic markers and out comes in severe leptospirosis in a tertiary care hospital from south India M. Prabhu, R. Valsalan, N. KS, B. Ramachandran KMC Manipal, Manipal, Karnataka, India Background: Leptospirosis is a common zoonotic disease causing epidemics all over the world. Severe leptospirosis with multiple organ involvement causing high mortality is common along costal India. APACHE III is the most recent version of the scoring system developed by Knaus and colleagues. So far no studies are available using APACHE III in severe leptospirosis in Indian setting. Develop simple scoring in leprospirosis to predict outcome. Prospective clinical study of APACHE III score and other independent variables as a predictor of mortality in patients with severe Leptospirosis. To develop simple scoring system to predict outcome measure Methods: 61 patients with diagnosis of severe Leptospirosis admitted in Kasturba Hospital Manipal, tertiary care hospital in south India during the period of May 2006 to June 2008. Results: During 2 year study period (May 2006- June 2008) 61 patients with Severe Leptospirosis were admitted in different ICUs of Kasturba Hospital, of whom13 were females and 48 were males.21 patients succumbed to their illness and 40 survived. Mean age was 48.38 ± 18.31 years among those who succumbed to Leptospirosis. All patients in dead group had hypotension in comparison to 25(65%) patients out of 40 patients in alive group. 20 out of 21 patients who succumbed had acute lung injury or acute respiratory distress syndrome. Artificial ventilation was associated with increased mortality (P
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