14th ICID - Poster Abstracts - International Society for Infectious ...

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When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 80.012 Session: Pediatric and Perinatal Infections Date: Friday, March 12, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Kawasaki disease in a children hospital at Dominican Republic, period January 2006-October 2009 C. S. Mota Hospital Dr. Robert Reid Cabral , Santo Domingo, Dominican Republic Background: Kawasaki is a febrile illness characterizes by the inflammation of middle-size arteries that affect children, primarily younger than 5 years, of unknown etiology. Since its description by Tomisaku Kawasaki, in Japan, 1967, has been a target of epidemiologic, clinical and laboratorial interest. Early recognition is one of its principal challenges, because, it is related with a good prognosis. In Dominican Republic the first’s cases were described in 1986. The target of this research is to describe the clinical characteristics of the Kawasaki disease’ cases in the principal pediatric hospital in Santo Domingo, Dominican Republic Methods: This is a descriptive, observational and cross-sectional study to determine the clinical and epidemiological characteristics of patients admitted with the diagnosis of Kawasaki disease in the Hospital Dr. Robert Reid Cabral from January 2006 to October 2009 Results: During the observational period in the Hospital Robert Reid Cabral were admitted 17 patients with the diagnosis of Kawasaki disease. 10 (58.8%) were female, 7(41.2%) male; 6 (35.2%) younger than 1 year; 7 (41.2%) 1-5 years; 4 (23.5%) older than 5 years. Fever was present in all of the cases, nevertheless, duration was quite different, from 5 to 20 days in 6 patients (35.7%); the clinical findings more frequently reported were conjunctival injection in 15 (88.2%) patients, cervical lymphadenopathy 14 (82%); strawberry tongue and erythema of oropharyngeal mucosa 12 (74.5%); skin rash and desquamation 10 patients (58.8%). Only one patient presented cardiac abnormalities. Three (3) patients were treated with immunoglobulin. No mortality reported Conclusion: The findings in the patients from the Dominican hospital were quite similar to those described in the medical literature, mismatching only in the female gender predominance, but it had little significance. Diagnosis was basically clinical, even though the apparent delay in the diagnosis and treatment, the outcome was satisfactory.
When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 80.013 Session: Pediatric and Perinatal Infections Date: Friday, March 12, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Epidemiology, clinical and microbiology characteristic of multiresistant Acinetobacter spp. bacteremia in a pediatric hospital in Argentina S. Ruvinsky, G. Fiorilli, G. Perez, B. Juzielewski, L. Mannino, L. Casimir, M. T. Rosanova, H. Lopardo, R. Bologna Hospital de Pediatria Dr. Juan P. Garrahan, Buenos Aires, Argentina Background: Multiresistant Acinetobacter species emerge as an important healthcareassociated pathogen. An understanding of the epidemiology is necessary in order to develop strategies to curtail their spread. Methods: The aim was to analyze the epidemiology, clinical characteristics and antimicrobial profile of multiresistant Acinetobacter spp. bacteremia (MAB) in a pediatric hospital. Methods: Demographic and clinical data from all MAB clinically relevant (2005 -2008) at were collected at Garrahan Hospital.Time–kill studies and a PCR assay with degenerate oligonucleotide primers were performed. Stata 8.0 was used for data analysis. Results: A total of 50 MAB were analyzed, 66 % was confirmed as A. baumannii and five clones were detected (clone 1:34%). Time-kill curves tested in the different clones showed only bactericidal effects in 3/ 5 with ampicillin-sulbactam plus gentamycin and in 5/5 with polymixin .The median age of the patients was 13.5 months (IQR: 6 a 54 months). The median length of stay before bacteremia was 16 days (IQR: 8-32 days), 94% of the patients acquired bacteremia in PICU. Eighty eight percent of the patients had underlying conditions: congenital heart diseases (34%), burns (25%) and onco-hematological disease (13.63%) were the most frequent. Ninety four percent received broad spectrum antibiotics (carbapenems and third-generation cephalosporin), 20% immunosuppressive therapy and 46% had malnutririon. All patients had invasive procedures before bacteremia: 90% central venous line, 80 % had previous surgery,76% mechanical ventilation and 52 % urinary catheter . The final diagnosis was: central venous catheter-associated bacteremia (40%), bacteremia related to skin and soft-tissue infections (26%) and bacteremia (24%). Antibiotics used for treatment were: colistin alone (52%), colistin plus carbapenem (26%), colistin plus piperacillin- tazobactam (10%), colistin plus ampicillin- sulbactam (4%) and cepefime plus colistin (2% respectively). The median length of therapy was 14 days (IQR: 14-21 days), 7/50 (14%) patients died but only 3 were related to bacteremia. Conclusion: MAB was detected in patients with medical underlying conditions and prolonged hospitalization. In vitro bactericidal effect was similar with colistin alone as well with the different combination tested. The development of innovative control strategies is needed in order to limit the spread of these pathogens
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