14th ICID - Poster Abstracts - International Society for Infectious ...

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When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 77.024 Session: Gram-positives & Miscellaneous Pathogens Date: Friday, March 12, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Characterization of community-acquired Staphylococcus aureus methicillin-resistant (CA-MRSA) vs methicillin susceptible Staphylococcus aureus (CA-MSSA) infection (Inf) in Argentinean children G. A. Yerino, M. S. Vazquez, C. Magneres, G. Abalos, C. I. Cazes, M. L. Vozza, C. I. Echave, V. Valle, M. Langard, A. Procopio, M. M. Contrini, E. L. Lopez Hospital de Niños "Ricardo Gutiérrez", Buenos Aires, Argentina Background: CA-MRSA inf are increased worldwide and few data are published from Latin America. Objective: to define the prevalence of CA-MRSA vs CA-MSSA in hospitalized children in our setting; to characterize the demoepidemiological, clinical and laboratory data between groups Methods: Restrospective study Jan`05 – March`08, at Hospital de Niños, Buenos Aires. CA Staphylocuccus aureus inf: positive culture 72 hs of admission consistent with CDC´s ABC criteria. Exclusion: patients with health care associated infection. Likert scale for parent´s education and frequency of bath score was performed. Chi2, t test and regression logistic model (LRM) were used. Results: A total of 302 Staph inf were studied: CA-MRSA:153 (51%) and CA-MSSA:149 (49%). CA-MRSA increased frequency from 39.8% in 2005 to 60% in 2008, (p=0.01).No difference between groups was observed in: age: 70.3(±61.5), median:51 mo; gender: male 187/302 (61.9%); underlying disease: 74/302 (24.5%); crowding: 125/302 (41.4%). CA-MRSA was related to lower parent´s education and less frequency of bath, p=0.009, respectively. Clinical and laboratory features: Infection CA-MRSA CA-MSSA p Skin and soft tissue 135/153 (88.2%) 199/149 (67.1%)
When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 77.025 Session: Gram-positives & Miscellaneous Pathogens Date: Friday, March 12, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Diphtheria tox gene polymorphism in . diphtheriae strains isolated in Russia during 2002-2009 S. Kombarova, I. Mazurova, O. Borisova, N. Gadua, T. Kornienko G.N. Gabrichevsky Institute of Epidemiology and Microbiology, Moscow, Russian Federation Background: Diphtheria tox gene is responsible for diphtheria toxin synthesis by diphtheria causative agent. We studied diphtheria tox gene structure in C. diphtheriae strains isolated in Russia over the period of decreased and sporadic incidence of diphtheria (2002-2009). Methods: 16 toxigenic strains from various regions of Russia (North-Western region, i.e. St.Petersburg; Central region, i.e. Moscow, Smolensk, and Tula; from Siberian region, i.e. Omsk) were used to determine the full nucleotide sequence of their tox gene. 13 of the strains were of the gravis biovar, the other 3 – of the mitis biovar. 2 strains were isolated from patients, 14 strains – from passive carriers. Also 115 nontoxigenic C. diphtheriae strains isolated between 2006 and 2009 were observed to identify nontoxigenic strains carrying a "silent" tox gene. Results: 12 point mutations in tox gene were registered between 2002-2009. In comparison, we have studied 40 strains circulating before and during diphtheria epidemic in Russia (1985 – 1993) and only 5 point mutations were revealed. By now 13 point mutations have been registered among srains isolated in 1985-1993 and 2002-2009. Majority of mutations did not lead to substitutions in amino acid sequence of diphtheria toxin. Over the period of decreased and sporadic incidence of the disease two point mutations corresponding to substitutions on amino acid level were registered. Such changes affected 4 out of 16 strains. Futher research was done to identify nontoxigenic C. diphtheriae strains carrying a "silent" tox gene. No nontoxigenic strains carrying a tox gene were identified. Comparing these results with the data collected over many years of monitoring showed that the percentage of nontoxigenic tox gene carrying strains in the strain population was different in different years. Thus, at the time of of sporadic incidence of the 1980s and during the period of epidemic rise (1990-1995) such strains were either registered at a very insignificant level (2-4%) or not registered at all. In the period of low diphtheria incidence following an epidemic rise (1996-2004), the concentration of nontoxigenic tox gene carrying strains considerably increased (up to 17%). Conclusion: Polymorphism of tox gene can create wide adaptation possibilities of diphtheria causative agent.
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