14th ICID - Poster Abstracts - International Society for Infectious ...

When citing these abstracts please use the following reference:
Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number.
Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1
is available electronically on http://www.sciencedirect.com
Final Abstract Number: 76.003
Session: Emerging Infectious Diseases
Date: Friday, March 12, 2010
Time: 12:30-13:30
Room: Poster & Exhibition Area/Ground Level
Type: Poster Presentation
Community-acquired Staphylococcus aureus infection in previously healthy neonates
G. Berberian 1 , G. Castro 2 , H. Lopardo 3 , C. Hernandez 4 , A. Mónaco 5 , M. T. Rosanova 3
1 hospital de pediatria JP garrahan, buenos aires, Argentina, 2 hospital de pediatria JP garrahan,
Buenos Aires, Argentina, 3 Hospital de Pediatria Dr. Juan P. Garrahan, Buenos Aires, Argentina,
4 Hospital de Pediatria JP Garrahan, Buenos Aires, Argentina, 5 Hospital de Pediatría JP
Garrahan, Buenos Aires, Argentina
Background: Community-Aquired S aureus (CA-Sa) resistance are changing in the last ten
years in Argentina, increasing methicillin-resistant S aureus (MRSA) strains. First case in our
neonatal unit was diagnosed in 2006.
Objectives: Identify clinical features, risk factors, sensibility and outcome of neonate with CA-Sa
infection.
Methods: Prospective observational study. We included previously healthy patients 30 days of
age admitted to the neonatal unit with CA-Sa infection from 2006 to 2009. We defined CA-Sa
infection based on CDC guidelines.
Results: We included 9 healthy neonate with CA-Sa infection. Vaginal labor was present in 7/9.
Mean gestational age 39 weeks, weight 3325 g, and < 3 birth hospital days .Of 9 S aureus
infections, 5 (56%) were MRSA .Six of 9 were male. Median age at symptoms onset was 12 days
(r:9-18).All infection involved skin and soft tissue (9/9) with pustulosis, omphalitis, mastitis, chest ,
facial/neck , inguinal and goin abscesses. Five of 9 had severe manifestation: sepsis,
ostheoarticular infection, orbital cellulitis and necrothizing pneumonia. Culture positive were
obtained in 7 from soft tissue , 4 blood and 2 joint . All received sistemic antibiotics. Four of 5
(80%) and 2/ 4 (50%) MRSA and MSSA infections respectively required surgical drainage. One
patient died because of sepsis.Maternal skin/soft tissue infection history occured with 3/ 4 MRSA
versus none of MSSA infections.
Conclusion: Epidemiology of CA-Sa infection is changing even in the newborn period, with
increasing MRSA strains. Male neonates 9-18 days of life were affected more often, Maternal
infection and surgical drainage has a strong association with MRSA isolation.