14th ICID - Poster Abstracts - International Society for Infectious ...

When citing these abstracts please use the following reference:
Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number.
Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1
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Final Abstract Number: 80.024
Session: Pediatric and Perinatal Infections
Date: Friday, March 12, 2010
Time: 12:30-13:30
Room: Poster & Exhibition Area/Ground Level
Type: Poster Presentation
Clinical and epidemiology characterization of children hospitalized with influenza A H1N1 (FLU
AH1N1) during the first wave of 2009 outbreak, Santiago, Chile
C. Sandoval 1 , C. Vizcaya 1 , C. Perret 2 , M. Ferrés 3 , C. Martinez 4 , P. Godoy 5 , P. Ferrer 5 , M.
Monge 3 , K. Abarca 1 , A. Castillo 3 , M. Potin 3 , J. C. Lopez 3
1 Clinical Hospital of Catholic University, Santiago, Chile, 2 Pontificia Universidad Catolica de Chile,
Santiago, Chile, 3 Catholic University, Santiago, Chile, 4 Infectious diseases and Molecular
Laboratory, Catholic University, SAntiago, Chile, 5 Infectious diseases and Molecular Laboratory,
Catholic University, Santiago, Chile
Background: In Chile flu AH1N1 affected mainly children between 5-14 years old (4500/100,000
pop) with highest hospitalization in children 5 years (90,8/100,000 pop). Objectives were to
describe epidemiological, clinical, virological and laboratory findings and to determine risk factors
for severe disease in pediatric patients.
Methods: Descriptive study of hospitalized children with confirmed flu AH1N1. We studied the
presence of the virus in biological samples (respiratory secretions, blood and urine) using realtime
RT-PCR and viral culture, at admission and at 3rd and 5thdays of treatment with oseltamivir.
Viral load from respiratory samples was standardized by copies/100,000 cells.
Results: 20 children were hospitalized with flu AH1N1. Twelve girls (60%), mean age 2.9 years
(1m-16y). Most were infected at home 30% (6), hospital 25% (5) and nursery/kindergarten 15%
(3). 65% had underlying diseases: recurrent wheezing (7), congenital heart disease (2) and
immunosuppression (2). The leading cause of hospitalization was oxygen requirements (50%),
respiratory failure (20%), deterioration of the underlying disease (10%), fever of unknown origin
and hyperemesis (5%). Fever (95%), cough (90%) and dyspnea (70%) were the most frequent
symptoms. Ten patients required ICU for an average of 16 days, median 8 days (1-60), 3 of them
had underlying diseases (recurrent wheezing and liver transplantation). Six patients required
mechanical ventilation and three of them needed high frequency oscillatory ventilation.
Complications: wheezing 55% (11), secondary bacterial infection 45% (10), athelectasis 30% (6)
and global respiratory failure 15% (3), no mortality. The average of the lymphocyte count in
ventilated patients was 715 ± 517 cells/ml and 3251 ± 2225 cells/ml in non ventilated patients (p<
0.0001). Presence of underlying disease and viral load were no associated with severe
respiratory failure. 14/15 patients had detectable virus in nasopharynx after 24-48 hours of
oseltamivir (127,000 to