14th ICID - Poster Abstracts - International Society for Infectious ...

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When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 84.009 Session: Virology and Viral Infections (Non-HIV) Date: Friday, March 12, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Infectious mononucleosis in Albanian children R. Petrela 1 , E. Kallfa 1 , G. Lito 1 , H. Hoxha 2 , G. Mullalli 2 , N. Como 1 1 University Hospital Centre "Mother Theresa", Tirana, AL, Albania, 2 University hospital center "Mother Theresa", Tirana, Albania, Albania Background: To study some of the epidemiological data, clinical manifestations, diagnosis and treatment of the children hospitalized in the pediatrics infectious diseases ward. Methods: In the study are included 47 children from 1-4 years hospitalized in Pediatrics Infectious Diseases Ward during 2003-2008. From the childrens cards we studied important data as: distribution according to age group, gender, residence, season and important clinical manifestation such as fever, fatigue, pharyngitis, generalized lymphadenopathy and splenomegaly. Confirmation of the diagnosis is done by specific serological tests (antibody anti-EBV). Results: According to age group 1-4 yr 30 cases (64%), 4-8 yr 11 cases (23%), 8-14 yr 6 cases (13%); gender male 35 cases (74%), female 12 cases (26%); residence city 36 cases (76%), village 11 cases (24%); season spring 12 cases (25%), summer 6 cases (13%), autumn 11 cases (23%), winter 18 cases (39%). Clinical manifestations: fever 47 cases (100%), Pharyngitis (hyperemic exudativ) 47 cases (100%), lymphadenopathy 37 cases (73%), cervicolatheral predominantly 25 cases (68%), splenomegaly 15 cases (32%), hepatomegaly 7 cases (15%). In 85% of cases was found leucocitosis (10000-26000 cel/mm), atypical lymphocytosis in peripheral blood (>10%), in 37 cases (79%) and elevated SGPT. Specific serological tests for anti body anti-EBV (anti-VCA-IgG and anti-VCA-IgM) were positive in all cases. 12 cases (25%) resulted with pulmonary infections, 5 cases (10%) with urinary tract infections and 3 cases (6%) with biliary tract infection. Conclusion: Infectious mononucleosis is a clinical syndrome caused by Epstein-Bar virus which is not rare and must be considered in pediatric population. This syndrome expressed clinically by the thriad; pharyngitis, lymphadenopathy and splenomegaly must make us suspect the diagnosis of infectious mononucleosis which is confirmed by specific serological tests. Therapy with corticosteroids for short periods (
When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 84.010 Session: Virology and Viral Infections (Non-HIV) Date: Friday, March 12, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Symptomatic, long-term Parvovirus B19 infection in otherwise healthy adults R. Manfredi University of Bologna, Bologna, Italy Background: Parvoviridae are part of air-, parenteral- and perinatal-transmitted ubiquitous viruses, whose associated signs and symptoms strongly depend on patient’s age and immune defence. Methods: All cases of symptomatic Parvovirus B19 infection in otherwise healthy adults which came to our attention since spring 2006 were prospectively investigated and followed-up. Results: In a 21-month period, 11 patients (7 females and 4 males), with a mean age of 36.9 (range 27-46) years with a symptomatic Parvovirus B19 infection were recorded and followed-up. Intrafamiliar exposure and occupational (health care) exposure were identified in two cases each. Clinical signs and symptoms included fever (100% of cases), polyarthralgia (90%), followed by headache (80%), anemia (70%), and rash. A mild-to-moderate myelosuppression of all hematological lines characterized 8 cases of 11 (72.7%), while increased serum transaminases were associated in 63.6% of patients. Three patients of ours deserved hospitalization (mean 10.8 days of admission), and five more cases were followed on Day-Hospital basis (for a median 75- day period); in four patients a treatment with i.v. high-dosage human immunoglobulins was performed. Elevated levels of specific serum anti-Parvovirus B19 IgM antibodies were detected in all cases. In a 33-year-old female a severe anemia and a persisting headache, vomiting, and neck stiffness, led to RBC transfusion and a diagnosis of meningoencephalitis, with positive search of IgM antibodies and Parvovirus B19 viremia (detected by RT-PCR) in the cerebrospional fluid which lasted up to three months, despite treatment with i.v. serum immunoglobulins. Conclusion: Parvovirus B19 infection may play a significant role also in adult, immunocompetent subjects, and the disease sometimes is not mild and self-limiting, requiring admission and/or frequent outpatient interventions in a significant number of cases. The causes supporting a persistant infection in immunocompetent subjects have not been investigated to date, as well as the pathogenesis of myelosuppression and severe polyartrhalgia. Symptomatic Parvovirus B19 infection is still an underestimated clinical condition, and therapeutic perspectives are extremely limited until now.
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