14th ICID - Poster Abstracts - International Society for Infectious ...

When citing these abstracts please use the following reference:
Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number.
Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1
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Final Abstract Number: 80.001
Session: Pediatric and Perinatal Infections
Date: Friday, March 12, 2010
Time: 12:30-13:30
Room: Poster & Exhibition Area/Ground Level
Type: Poster Presentation
Effect of zinc supplementation on clinical course of acute diarrhea in patients admitted in Ali
Asghar Children Hospital Medical Center Iran University of Medical SciencesTehran Iran
K. Mahlouji
Iran University of Medical Sciences, Tehran, Iran, Islamic Republic of
Background: Pilot studies have been conducted in number of countries (Brazil, Egypt, Ethiopia,
India, Mali, Pakistan and Philippines) prior to the implementation of large community-based
studies to introduce zinc in the management of acute diarrhea, preliminary results of these
studies show two interesting observations: ORS use rate increase; Antimicrobial use rate
significantly decrease with zinc is prescribed with ORS solution.
Methods: We conducted an interventional study (clinical trial) in patients who admitted in Ali -
Asghar Children Hospital, with one episode of acute diarrhea, the patients were divided into two
groups(case=75 and control =75).
In the case group zinc sulfate was added as supplement.
In control group no supplement was added to usual treatments.
Zinc prescribed as zinc sulfate syrup for 14 days during and after diarrhea(10 mg /day for infants
6 mo of age).
Results: Mean duration time of diarrhea in control group without Zinc Sulfate was 5.63 days and
for that of case group using zinc sulfate was 3.21 days. Data was analyzed by SPSS-13 software
using T-test and Chi-square Test, there was a significant difference between 2 groups in duration
of diarrhea (P value=0.001).
Conclusion: In our study prescription of Zinc sulfate in acute diarrhea similar to other studies
reduced the duration of acute diarrhea. Therefore Zinc Sulfate has an important role in treatment
of acute diarrhea and should be considered as a supplement in all cases of diarrhea.