14th ICID - Poster Abstracts - International Society for Infectious ...

More documents

Recommendations

Info

When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 80.016 Session: Pediatric and Perinatal Infections Date: Friday, March 12, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation The association between vitamin D deficiency, folate deficiency and seropositivity to persistent pathogens among U.S. children A. Simanek 1 , J. Dowd 2 , A. Aiello 1 1 University of Michigan, Ann Arbor, MI, USA, 2 Hunter College, New York, NY, USA Background: Studies have documented the association between vitamin deficiency and immune system dsyfunction. Few studies have examined the relationship between vitamin deficiencies and infection with specific pathogens. The purpose of this study was to investigate whether vitamin D and/or folate deficiency (levels < 20 ng/ml and < 362.6 nmol/L, respectively) are associated with seropositivity to persistent pathogens including cytomegalovirus (CMV), herpes simplex virus-1 (HSV-1) and helicobacter pylori (H. pylori) as well as with total pathogen burden (total number of the above pathogens for which a subject is seropositive, range 0-3). Methods: We used data from the National Health and Nutrition Examination Survey III, including subjects 12-19 years of age who were tested for seropositivity to each pathogen and serum levels of vitamin D or folate (N=1275). Logistic regression was conducted to generate the odds ratio (OR) and 95 percent confidence intervals (CI) for seropositivity to each pathogen and ordered logit regression was used to generate the OR and 95% CI for seropositivity to an additional pathogen (ie., increasing total pathogen burden). Results: In crude models, vitamin D deficiency was associated with seropositivity to CMV (OR 2.09, 95% CI (1.60, 2.74), HSV-1 (OR 1.53, 95% CI (1.14, 2.05) and seropositivity to an additional pathogen (OR 1.64, 95% CI (1.10, 2.44). Only the association between vitamin D deficiency and CMV remained after controlling for gender, race/ethnicity and poverty income ratio (OR 1.38, 95% CI (1.01, 1.89). Folate deficiency was associated with seropositivity to HSV-1 (OR 1.32, 95% CI (1.04, 1.68) in the crude model, however this association was no longer signficant after controlling for confounders. Conclusion: Vitamin D deficiency was associated with CMV seropositivity in this U.S. representative sample of children age 12-19. Vitamin supplementation could serve to lower the prevalence of CMV infection in children in the U.S.
When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 80.017 Session: Pediatric and Perinatal Infections Date: Friday, March 12, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Pilot study to determine feasibility of development of an influenza clinical diagnostic tool R. Nipp, T. Bell, D. Ruhl, C. Lee, J. Kirkland Texas Tech University Health Sciences Center, Amarillo, TX, USA Background: Influenza is a costly healthcare burden worldwide. Diagnosing influenza in a timely and accurate manner allows the proper appropriation of scarce healthcare resources and antiviral medications. Unfortunately, current testing technologies are either insensitive (rapid antigen tests), nonspecific (clinical diagnosis) or untimely and expensive (rt-PCR). Ultimately, treatment and management decisions for influenza are suboptimal due to lack of diagnostic accuracy. The need for differentiating influenza from other viral infections led us to the hypothesis that influenza may have a large affect on certain vital signs allowing development of a clinical diagnostic tool. Methods: We prospectively collected data, including demographics, vital signs and rapid influenza antigen testing results from patients who presented to primary care clinics with fever and a cough or fever and a sore throat (influenza like illness) of 2 days or less duration. A total of 38 children were included in this analysis. Subjects’ heart rates were converted to a uniform unit (heart rate ratio) by dividing their heart rate by the median heart rate for age. Likelihood ratios (LR) were determined for apparently significant vital sign thresholds. Results: 14 children were influenza A positive by rapid antigen testing. Compared to rapid antigen negative controls, clinically significant likelihood ratios were determined for heart rate ratio greater than 1.4 (Positive LR = 10 (CI 1.4-76.9)) and a combination of current temperature less than 38C with a heart rate ratio less than 1.25 (Negative LR = 0.24 (CI 0.06-0.99)). Other vital signs yielded no predictive significance. Graphs of Likelihood Ratios Conclusion: Although limited by its small size and the use of the rapid antigen test as a proxy to a gold standard, we feel that this pilot study highlights the feasibility of developing a clinical influenza diagnostic tool. Children presenting for medical care with HR ratios >1.4 may be prioritized to treatment based on the higher post-test probability of influenza. Perhaps of more utility, patients with Temp
Page 1 and 2:
When citing these abstracts please
Page 3 and 4:
Page 5 and 6:
Page 7 and 8:
Page 9 and 10:
Page 11 and 12:
Page 13 and 14:
Page 15 and 16:
Page 17 and 18:
Page 19 and 20:
Page 21 and 22:
Page 23 and 24:
Page 25 and 26:
Page 27 and 28:
Page 29 and 30:
Page 31 and 32:
Page 33 and 34:
Page 35 and 36:
Page 37 and 38:
Page 39 and 40:
Page 41 and 42:
Page 43 and 44:
Page 45 and 46:
Page 47 and 48:
Page 49 and 50:
Page 51 and 52:
Page 53 and 54:
Page 55 and 56:
Page 57 and 58:
Page 59 and 60:
Page 61 and 62:
Page 63 and 64:
Page 65 and 66:
Page 67 and 68:
Page 69 and 70:
Page 71 and 72:
Page 73 and 74:
Page 75 and 76:
Page 77 and 78:
Page 79 and 80:
Page 81 and 82:
Page 83 and 84:
Page 85 and 86:
Page 87 and 88:
Page 89 and 90:
Page 91 and 92:
Page 93 and 94:
Page 95 and 96:
Page 97 and 98:
Page 99 and 100:
Page 101 and 102:
Page 103 and 104:
Page 105 and 106:
Page 107 and 108:
Page 109 and 110:
Page 111 and 112:
Page 113 and 114:
Page 115 and 116:
Page 117 and 118:
Page 119 and 120:
Page 121 and 122:
Page 123 and 124:
Page 125 and 126:
Page 127 and 128:
Page 129 and 130:
Page 131 and 132:
Page 133 and 134:
Page 135 and 136:
Page 137 and 138:
Page 139 and 140: When citing these abstracts please
Page 189: When citing these abstracts please
Page 241 and 242:
Page 243 and 244:
Page 245 and 246:
Page 247 and 248:
Page 249 and 250:
Page 251 and 252:
Page 253 and 254:
Page 255 and 256:
Page 257 and 258:
Page 259 and 260:
Page 261 and 262:
Page 263 and 264:
Page 265 and 266:
Page 267 and 268:
Page 269 and 270:
Page 271 and 272:
Page 273 and 274:
Page 275 and 276:
Page 277 and 278:
Page 279 and 280:
Page 281 and 282:
Page 283 and 284:
Page 285 and 286:
Page 287 and 288:
Page 289 and 290:
Page 291 and 292:
Page 293 and 294:
Page 295 and 296:
Page 297 and 298:
Page 299 and 300:
Page 301 and 302:
Page 303 and 304:
Page 305 and 306:
Page 307 and 308:
Page 309 and 310:
Page 311 and 312:
Page 313 and 314:
Page 315 and 316:
show all

14th ICID - Poster Abstracts - International Society for Infectious ...

You also want an ePaper? Increase the reach of your titles

Delete template?

Save as template?