14th ICID - Poster Abstracts - International Society for Infectious ...

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When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 79.004 Session: Obstetrical-Gynecological, Surgical and Sexually Transmitted Infections Date: Friday, March 12, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Frequent infections in Mexican women experiencing spontaneous pregnancy loss L. Conde-Ferráez 1 , R. Suarez-Allen 1 , L. Manzano-Cabrera 1 , M. R. Gonzalez-Losa 1 , G. Koh-Tec 2 , M. Perez-Tuyub 2 , J. Camara-Mejia 1 , J. Carrillo-Martinez 3 , M. Puerto-Solis 1 1 Centro de Investigaciones Regionales, Universidad Autonoma de Yucatan, Merida, Yucatan, Mexico, 2 Universidad Autónoma de Yucatán, Merida, Yucatan, Mexico, 3 Instituto Mexicano del Seguro Social, Merida, Mexico Background: Some maternal infections especially during the early gestation can result in fetal loss or malformations. Gestation represents an altered immunological state which could predispose to various infections, and in particular, latent viral infections might be reactivated during this period. In this study we aimed to determine the prevalences of viral and protozoan pathogens, within women at reproductive age experiencing spontaneous pregnancy loss in southeast Mexico, and the epidemiological variables present. Methods: Women requiring medical attention for spontaneous abortion in a Social Security Hospital were randomly invited to participate. After consent, an interview was applied; serology tests for IgM antibodies against human cytomegalovirus (CMV), Herpes Simplex virus (HSV), and Toxoplasma gondii were performed. Cervical cells were PCR tested for Human Papilomavirus (HPV) infection. Results: From 143 participants, 113 (79.6%) were younger than 35 years old, and only 11 (7.7%) were younger than 20 years old. 90% presented miscarriages on the first trimester. 19.6% had experienced a previous pregnancy loss; 33.6% had never given birth to a live child and 66.4% had delivered one or more live children. From 141 serum samples tested, 60.3% (85/141) were positive to any of the infections: 17 (12 %) were T. gondii positive; 67 (47.5%) were CMV positive and 40 (28.4%) HSV positive. From 139 cervical samples tested, 34 (24.4%) were HPV+. Interestingly, 27.3% of HPV positive women have had repetitive abortions comparing to 17.4% of HPV negative women. Multiple infections were found in 42.4% of the seropositive samples, and importantly 19 (22.3%) were also positive to HPV cervical infection. One patient was positive to all infections. Conclusion: Pregnancy loss is attributed to several factors including maternal age. It was worrisome finding a high frequency of spontaneous abortions at young age. Recognizing infections in the mother is an important part of prenatal care. HPV prevalences found were higher than previously reported for southeast Mexico. HPV studies in our region are particularly important because the incidence of cervical cancer is amongst the highest in Mexico. Also, the highest nationwide incidence of clinically identified genital herpes is reported for our State. Although our data are limited, the high prevalences of infectious agents often related to pregnancy loss and the high frequency of multiple infections found in women at reproductive age set important basis for further investigation.
When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 79.005 Session: Obstetrical-Gynecological, Surgical and Sexually Transmitted Infections Date: Friday, March 12, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Maternal group B Streptococcus colonization: Prevalence, risk factors, phenotypical and genotypical characteristics in a Brazilian population T. S. Pires 1 , M. Turchi 2 , M. C. D. P. B. André 2 , J. L. Cardoso 2 , L. E. P. R. Schmaltz 1 , O. M. Peres 1 , A. L. Andrade 2 1 Hospital Materno Infantil , Goiania, Brazil, 2 Federal University of Goias, Goiania, Brazil Background: Maternal group B Streptococcus (GBS) colonization is considered to be the most important risk for invasive infections in the newborn. To reduce the incidence of neonatal infection two preventive strategies have been proposed: universal screening for all pregnant women or a risk-factor-based approach. However, prevention and treatment strategies have not yet been adopted in many developing countries. This study aims to estimate the prevalence, to investigate risk factors for GBS colonization and to describe phenotypical and genotypical characteristics of isolated strains from pregnant women in Goias-Central Brazil. Methods: A cross sectional study was carried out among 198 pregnant women, > 32o weeks´ gestation, attending a reference public health unit, from March to June 2009. Socio-demographic and obstetric profiles were investigated using a standard questionnaire. Samples of vaginal and rectal secretion were collected and placed into selective enrichment broth Todd-Hewitt. Tests for GBS identification (gram, catalase and CAMP) followed by susceptibility test using antibiotic disk diffusion technique were performed. Genetic diversity was assessed by pulsed-field gel electrophoresis (PFGE). Descriptive and analytic statistical tests were applied (SPSS 13.0). Results: Thirty pregnant women were colonized by GBS yielding a prevalence of 15.2% (IC95% 10.5-20.9). Pregnant women younger than 20 years and with low income had higher risk of GBS colonization, in univariate analysis (p
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