14th ICID - Poster Abstracts - International Society for Infectious ...

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When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com or organ (liver, brain or heart) damage. Early intensive care must be considered in patients with these initial poor prognostic factors.
When citing these abstracts please use the following reference: Author(s) of abstract. Title of abstract [abstract]. Int J Infect Dis 2010;14S1: Abstract number. Please note that the official publication of the International Journal of Infectious Diseases 2010, Volume 14, Supplement 1 is available electronically on http://www.sciencedirect.com Final Abstract Number: 84.039 Session: Virology and Viral Infections (Non-HIV) Date: Friday, March 12, 2010 Time: 12:30-13:30 Room: Poster & Exhibition Area/Ground Level Type: Poster Presentation Detection and clinical characterization of WU polyomavirus with acute respiratory tract infection in children, Guangdong of China X. Lu 1 , Q. Wang 1 , W. L. Zhuang 2 , G. Y. Lin 2 1 Affiliated Shenzhen Futian People’S Hospital of Guangdong Medical College, ShenZhen, China, 2 Second Affiliated Hospital of Shantou University Medical College, ShanTou, China Background: In 2007, Gaynor et al. discovered a previously unidentified human polyomavirus in respiratory sec retions obtained from human patients with symptoms of acute respiratory tract infection. This new virus was designated WU polyomavirus.To investigate the frequency of it infections in GuangDon g, China, We sought to describe the detection and clinical characterization of WU Polyomavirus w ith infection in Children. Methods: From July 2008 through June 2009, nasopharyngeal aspirates were collected from 771 children who were hospitalized with acute lower respiratory tract infection in Second Affiliated Hospital of Shantou University Medical College, and 82 were asymptomatic who visited the wellbeing clinic . WU Polyomaviruses was detected by using PCR technology and was identified by using DNA se quences. All WU polyomavirus positive specimens were screened for 9 commen viruses (influenz a A and B; RSV; PIV 1 and 3; human metapneumovirus; human bocavirus; adenovirus ; rhinoviru s)by using PCR or RT-PCR. Results: In this study, fifteen of the 771 tested specimens with acute lower respiratory tract infection were positive for W U polyomavirus, the positive rate was 1.95%. and all of the asymptomatic children who visited the wellbeing clinic were negative. Positive specimens were noted for patients 2 months to 48 months of age, the median age was 18.8 months. Of the 15 WU Polyomaviruses positive patients, 9 (60%) were male.,6(40%) were female.WU polyomavirus was the sole virus detected in 9 specimens(60 %) from patients with acute respiratory tract infection . WU polyomavirus were associated with the coinfection of another respiratory virus in 6 of 15 (40%) , most frequently with RSV (n = 4) ,followe d by adenovirus (n = 1) and rhinovirus (n = 1). The most common clinical findings in the patients with WU polyomavirus are cough ,fever , wheezing.The most frequent diagnoses were pneumoni a (n=8),bronchiolitis(n=4), upper respiratory tract infections (n=2) and bronchitis(n=1).A severe ca se was complication with viral encephalitis . Conclusion: We suggests that WU Polyomaviruses may be a respiratory pathogen because WU polyomavirus was the sole virus detected in 9 specimens from patients with respiratory illness and all of the as ymptomatic were negative.The most common clinical findings are cough and wheezing.Young chi ldren are the main target. And the pathogenetic condition are generally mild. More comprehensiv e studies are required to prove these viruses are agents causing respiratory disease.
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