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GTMB 7 - Gene Therapy & Molecular Biology

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George et al: <strong>Gene</strong> therapy for vascular diseasesDichek DA, Anderson J, Kelly, A.B, Hanson S, Harker L (1996)Enhanced in vivo antithrombotic effects of endothelial cellsexpressing recombinant plasminogen activators transducedwith retroviral vectors. Circulation 93, 301-309.Dishart K, Denby, L, George S, Nicklin S, Yendluri S, Tuerk, M,Kelley, M, Donahue B, Newby, A, Harding T, Baker A(2003) Third-generation lentivirus vectors efficientlytransduce and phenotypically modify vascular cells:implications for gene therapyapy. J Mol Cell Cardiol 35,739-748.Dobrzynski E, Yoshida H, Chao J (1999) Adenovirus-mediatedkallikrein gene delivery attenuates hypertension and protectsagainst renal injury in deoxycorticosterone-salt rats.Immunopharmacology 44, 57-65.Dobrzynski E, Wang C, Chao J (2000) Adrenomedullin genedelivery attenuates hypertension cardiac remodeling andrenal injury in deoxycorticosterone acetate-salt hypertensiverats. Hypertension 36, 995-1001.Dunn P, Newman K.D, Jones M, Yamada I, Shayani V, VirmaniR, Dicheck, D (1996) Seeding of vascular grafts withgenetically modified endothelial cells. Secretion ofrecombinant TPA results in decrease seeded cell retention invitro and in vivo. Circulation 93, 1439-1446.Dzau V, Mann M, Morishita R, Kaneda Y (1996) Fusigenic viralliposome for gene therapy in cardiovascular diseases. ProcNatl Acad Sci USA 93, 11421-11425.Ehsan A, Mann M, Dell'Acqua G, Dzau V (2001) Long-termstabilization of vein graft wall architecture and prolongedresistance to experimental atherosclerosis after E2F decoyoligoneucleotide <strong>Gene</strong> Ther. J Thorac Cardiovasc Surg121, 714-722.Ehsan A, Mann M, Dell'Acqua G, Tamura K, Braun-Dullaeus R,Dzau V (2002) Endothelial healing in vein grafts.Proliferative burst unimpaired by genetic therapy ofneointimal disease. Circulation 105 (1686-1692).Emanueli C, Madeddu P (2001) Angiogenesis <strong>Gene</strong> Ther torescue ischaemic tissues: achievements and furturedirections. Br J Pharm 133, 951-958.Emanueli C, Salis M, Pinna A, Stacca T, Milia A, Spano A, ChaoJ, Chao L, Sciola L, Madeddu P (2002) Prevention ofdiabetes-induced microangiopathy by human tissue kallikreingene transfer. Circulation 106, 993 - 999.Engelhardt J.F, Litzky, L, Wilson J (1994) Prolonged transgeneexpression in cotton rat lung with recombinant adenovirusesdefective in E2a. Human <strong>Gene</strong> Ther 5, 1217-1229.Engelse MA, Lardenoye JP, Neele J, Grimbergen J, de VriesM.R, Lamfers M, Pannekoek, H, Quax, P, deVries C M(2002) Adenoviral activin A expression prevents intimalhyperplasia in human and murine blood vessels bymaintaining the contractile smooth muscle cell phenotype.Circ Res 90, 1128-1134.Fennell J.P, Brosnan M, Frater A, Hamilton CA, Alexander M.Y,Nicklin SA, Heistad D.D, BAker A, Dominiczak, A.F (2002)Adenovirus-mediated overexpression of extracellularsuperoxide dismutase improves endothelial dysfunction in arat model of hypertension. <strong>Gene</strong> Ther 9, 110-117.Fox, J (2003) US authorities uphold suspension of SCID <strong>Gene</strong>Ther. Nat Biotechnol 21, 217-217.French, B, Mazur W, Ali N, Geske R, finnigan J, Rodgers G,Roberts R, Raizner A (1994a) Percutaneous transluminal invivo gene transfer by recombinant adenovirus in normalporcine coronary arteries atherosclerotic arteries and twomodels of coronary restenosis. Circulation 90, 2402-2413.French, BA, Mazur W, Geske R, Bolli R (1994b) Direct in vivogene transfer into procine myocardium using replicationdeficientadenoviral vectors. Circulation 90, 2414-2424.Furman C, Luo Z, Walsh, K, Duverger N (2002) Sytemic tissueinhibitor of metalloproteinase-1 gene delivery reducesneointimal hyperplasia in balloon-injured rat carotid artery.FEBS Letters 531, 122-126.Gangadharan S, Imai M, Rhynhart K, Sevigny, J, Robson S,Conte M (2001) Targeting platelet aggregation: CD39 genetransfer augments nucleoside triphosphatediphosphohydrolase activity in injured rabbit arteries.Surgery 130, 296-303.George S, Capogrossi M Angelini G, Baker A (2001) Wild typep53 gene transfer inhibits neointima formation in humansaphenous vein by modulation of smooth muscle cellmigration and induction of apoptosis. <strong>Gene</strong> Ther 8, 668-676.George S, Johnson J, Angelini G.D, Newby, A, Baker A (1998)Adenovirus-mediated gene transfer of the human TIMP-1gene inhibits SMC migration and neointima formation inhuman saphenous vein. Human <strong>Gene</strong> Ther 9, 867-877.George S, Lloyd C Angelini G.D, Newby, A, Baker A (2000)Inhibition of late vein graft neointima formation in humanand porcine models by adenovirus-mediated overexpressionof tissue inhibitor of metalloproteinase-3. Circulation 101,296-304.George S, Zaltsman A.B, Newby, A.C (1997) Surgicalpreparative injury and neointima formation increase MMP-9expression and MMP-2 activation in human saphenous vein.Cardiovasc Res 33, 447-459.George S, Baker A, Angelini G, Newby, A.C (1998) <strong>Gene</strong>transfer of tissue inhibitor of metalloproteinase-2 inhibitsmetalloproteinase activity and neointima formation in humansaphenous veins. <strong>Gene</strong> Ther 5, 1552-1560.Gossen M, Bujard H (1992) Tight control of gene expression inmammalian cells by tetracycline-responsive promoters. ProcNatl Acad Sci USA 89, 5547-5551.Grines C, Watkins M, Helmer G, Penny, W, Brinker J, JD M,West A, Rade J, Marrott P, Hammond H, Engler R (2002)Angiogenic <strong>Gene</strong> <strong>Therapy</strong> (AGENT) trial in patients withstable angina pectoris. Circulation 105, 1291-1297.Guzman R, Hirschowitz, EA, Brody, S, Crystal R, Epstein S.E,Finkel T (1994) In-vivo suppression of injury-inducedvascular smooth-muscle cell accumulation using adenovirusmediatedtransfer of the herpes-simplex virus thymidinekinase gene. Proc Natl Acad Sci USA 91 (22), 10732-10736.Hammond H.K, McKirman M (2001) Angiogenic <strong>Gene</strong> <strong>Therapy</strong>for heart disease: a review of animal studies and clinicaltrials. Cardiovasc Res 49, 561-567.Hanna A.K, Fox, J Neschis D, Safford S.D, Swain J, Golden M(1997) Antisense basic fibroblast growth factor gene transferreduces neointimal thickening after arterial injury. J VascSurg 25, 320-325.Harrell R, Rajanayagam, S, Doanes A, Guzman R, Hirschowitz,EA, Crystal R, Epstein S.E, Finkel T (1997) Inhibition ofvascular smooth muscle cell proliferation and neointimalaccumulation by adenovirus-mediated gene transfer ofcytosine deaminase. Circulation 96, 621-627.Hart S, Collins L, Gustafsson K, Fabre J (1997) Integrinmediatedtransfection with peptides containing arginineglycine-asparticacid domains. <strong>Gene</strong> Ther 4, 1225-1230.Havenga M E, Lemckert A C, Grimbergen J, Vogels R, HuismanL, Valerio D, Bout A, Quax, P.H (2001) Improved146

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