GTMB 7 - Gene Therapy & Molecular Biology

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Almazán et al: Expressed sequence tags in Ixodes scapularisM. musculus (155) DLKEGICLSALWYNH--------EQ----------CCWGSNETTFEERDKS. tuberosum (108) GFKLLLTSNLMLDGK-----------------------------------S. cerevisiae (102) NWKTGHCQRNWLLNKS-------------------FCCNGVVNEVTSTSNConsensus (272) DLK GIC AFWLNR EQ CCW SN T F DE. coli (53) FDKGVAWLQNQRMGALVHTADNYPLLLTVAFLCSAVLAMFGYFLVRKYAPO. mossambicus (130) CPQWKSWAELILGQ--AEGPGSYIMNYFMYIYWALSFAFLAVCLVKVFAPX. laevis (178) CPEWRSWSQLVLGR--SEGAFPYILNYFMYVMWALLFSLLAVLLVRNFAPI. scapularis (32) CKQWYRWPEMFDSGMDKDGAGFYLLSYLLYVMWSVLFATLAVMLVRTFAPC. elegans (172) CKAWTKWPWMLNYYN-SSSFLFLFLEWIFYIGWAVAMSTLAVLFVKIFAPD. melanogaster (254) CSTWKTWPEIFGLD--RNGTGPYIVAYIWYVLWALLFASLSASLVRMFAPL. major (138) CGEYYSWGEFFLGR---DNHVVAFVDFVMYVSFSTMAAVTAAYLCKTYAPA. gambiae (303) CSQWYAWSEIFTSS--REGFGAYVISYFFYIMWAMLFALLAASLVRMFAPM. musculus (187) CPQWKTWAELIIGQ--AEGPGSYIMNYIMYIFWALSFAFLAVSLVKVFAPS. tuberosum (123) ----------------------YFQAFAAFAGCNVFFATCAAALCAFIAPS. cerevisiae (133) LLLKRQEFECEAQG-LWIAWKGHVSPFIIFMLLSVLFALISTLLVKYVAPConsensus (322) C W W EL EG YIL YIMYILWALLFA LA LVK FAPE. coli (103) EAGGSGIPEIEGALE---DQRPVRWWRVLPVKFFGGLGTLGGGMVLGREGO. mossambicus (178) YACGSGIPEIKTILSGF-IIRGYLGKWTLMIKTITLVLAVASGLSLGKEGX. laevis (226) YACGSGIPEIKTILSGF-IIRGYLGKWTLIIKTMTLVLAVSSGLSLGKEGI. scapularis (82) YACGSGIPEIKTILSGF-IIRGYLGKWTLTIKSVCLVLAVGAGLSLGKEGC. elegans (221) YACGSGIPEIKCILSGF-VIRGYLGKWTFIIKSVGLILSSASGLSLGKEGD. melanogaster (302) YACGSGIPEIKTILSGF-IIRGYLGKWTLLIKSVGLMLSVSAGLTLGKEGL. major (185) YASGGGIAEVKTIVSGH-HVKRYLGGWTLITKVVGMCFSTGSGLTVGKEGA. gambiae (351) YACGSGIPEIKTILSGF-IIRSYLGKWTLIIKSVGIMLSVSAGLSLGKEGM. musculus (235) YACGSGIPEIKTILSGF-IIRGYLGKWTLMIKTITLVLAVASGLSLGKEGS. tuberosum (151) AAAGSGIPEVKAYLNG-IDAHSILAPSTLLVKIFGSILGVSAGFVVGKEGS. cerevisiae (182) MATGSGISEIKVWVSGFEYNKEFLGLLTLVIKSVALPLAISSGLSVGKEGConsensus (372) YACGSGIPEIKTILSGF IIRGYLGKWTLIIKSVGLVLAVSSGLSLGKEGE. coli (150) PTVQIGGNIGRMV----------LDIFRLKG--DEARHTLLATGAAAGLAO. mossambicus (227) PLVHVACCCGNIF----------SYLFPKYSKNEAKKREVLSAASAAGVSX. laevis (275) PLIHVACCCGNIL----------CHLFTKYRKNEAKRREVLSAAAAAGVSI. scapularis (131) PLVHVACCIGNIF----------SYLFPKYGKNEAKKREILSAAAAAGVSC. elegans (270) PMVHLACCIGNIF----------SYLFPKYGLNEAKKREILSASAAAGVSD. melanogaster (351) PMVHIASCIGNIF----------SHVFPKYGRNEAKKREILSAAAAAGVSL. major (234) PFVHIGACVGGII----------SGALPSYQQ-EAKERELITAGAGGGMAA. gambiae (400) PMVHIASCIGNIL----------SYLFPKYGRNEAKKREILSAAAAAGVSM. musculus (284) PLVHVACCCGNIF----------SYLFPKYSTNEAKKREVLSAASAAGVSS. tuberosum (200) PMVHTGACIANLLGQGGSRKYHLTWKWLKYFKNDRDRRDLITCGAAAGVAS. cerevisiae (232) PSVHYATCCGYLL----------TKWLLRDTLTYSTQYEYLTAASGAGVAConsensus (422) PLVHIA CIGNILSYLFPKY KNEAKKREILSAAAAAGVSE. coli (188) AAFNAPLAGILFIIEEMRPQ--FRYTLISIKAVFIGVIMSTIMYRIFNHEO. mossambicus (267) VAFGAPIGGVLFSLEEVSYY--FPLKTLWRSFFAALVAAFVLRSINPFGNX. laevis (315) VAFGAPIGGVLFSLEEVSYY--FPLKTLWRSFFAALVAAFTLRSINPFGNI. scapularis (171) VAFGAPIGGVLFSLEEVSYY--XPLKTLWRSFFCALVAASVLRSINPFGNC. elegans (310) VAFGAPIGGVLFSLEEASYY--FPLKTMWRSFFCALVAGIILRFVNPFGSD. melanogaster (391) VAFGAPIGGVLFSLEEVSYY--FPLKTLWRSFFCALIAAFVLRSLTPFGNL. major (273) VAFGAPVGGVIFALEDVSTS--YNFKALMAALICGVTAVLLQSRVDLWHTA. gambiae (440) VAFGAPIGGVLFSLEEVSYY--FPLKTLWRSFFCALIAAFILRSINPFGNM. musculus (324) VAFGAPIGGVLFSLEEVSYY--FPLKTLWRSFFAALVAAFVLRSINPFGNS. tuberosum (250) AAFRAPVGGVLFALEEIASW--WRSALLWRTFFTTAIVAMVLRSLIQFCRS. cerevisiae (272) VAFGAPIGGVLFGLEEIASANRFNSSTLWKSYYVALVAITTLKYIDPFRNConsensus (472) VAFGAPIGGVLFSLEEVSYY FPLKTLWRSFF ALVAA VLRSINPFGNE. coli (236) VA----------LIDVGKLSDAPLO. mossambicus (315) SR----------LVLFYVEYHTPWX. laevis (363) SR----------LVLFYVEFHAPWI. scapularis (219) DH----------LVMFYVEYDFPWC. elegans (358) NQ----------TSLFHVDYMMKWD. melanogaster (439) EH----------SVLFFVEYNKPWL. major (321) GR----------IVQFSVNYQHNWA. gambiae (488) EH----------SVLFYVEYNKPWM. musculus (372) SR----------LVLFYVEYHTPWS. tuberosum (298) GGNCGLFGQGGLIMFDVNSGVSNYS. cerevisiae (322) GR----------VILFNVTYDRDWConsensus (522)LVLFYVEY PW50
Gene Therapy and Molecular Biology Vol 7, page 51BFigure 2. Analysis of clone 4G11 identical to chloride channel. (A) Alignment of M. musculus (XP_134186), D. melanogaster(AAM76180), Solanum tuberosum (T07608), Oreochromis mossambicus (AAD56388), A. gambiae (EAA11899), C. elegans(NP_495940), Leishmania major (strain Friedlin) (T02805), Saccharomyces cerevisiae (P37020), Escherichia coli K12 (AAC73266),and Xenopus laevis (CAA71071) protein sequences and the translation product of clone 4G11 identified as a fragment of I. scapularischloride channel (AY296114). Protein sequences are shown in the single letter amino acid code. Identical amino acids are shown in redand amino acids conserved in 6-10 of 11 sequences are shown in blue. (B) Phylogenetic tree constructed from analysis of chloridechannel protein sequences based on a sequence distance method utilizing the Neighbor Joining algorithm of Saitou and Nei (1987).D. melanogaster PHAQGFIEVDQNVTTHHPIVREEKIVPNMQINGYENPTYKYFEI. scapularis PQAQGFVQVDQGALPASPEER---HLASMQVNGYENPTYKYFEA. gambiae PHAQGFVEVDQAVGAPVTPEE--RHVANMQINGYENPTYKYFEConsensus PHAQGFVEVDQ V P ER HVANMQINGYENPTYKYFEFigure 3. Analysis of clone 2C12 identical to beta-amyloid precursor protein. Alignment of D. melanogaster (AF181628) and A.gambiae (EAA07868) protein sequences and the translation product of clone 2C12 identified as I. scapularis beta-amyloid peptide (ß-AP) (AY296115). Protein sequences are shown in the single letter amino acid code. Identical amino acids are shown in red and aminoacids conserved in 2 of 3 sequences are shown in blue.Table 4. Characterization of I. scapularis ESTs encoding for ribosomal proteinsEST clone Predicted protein Identical aminoacids4F71A2Elongation factor 1-alpha 95%85%SpeciesNeacarus texanusMus musculusGenBank accessionnumberAAK12660NP_0319321A10 Elongation factor-2 88%80%Mastigoproctus giganteusMus musculusAAK12348BAC262031C11 eIF-5A 65%59%Drosophila melanogasterMus musculusAAM68297XP_2033361F62C3RpS4 79%75%Spodoptera frugiperdaMus musculusAAL26580AAH091002B8 RpS11 92%80%Dermacentor variabilisMus musculusAAO92287XP_1334772F8 Laminin receptor 1(RpSA)66%73%Anopheles gambiaeMus musculusEAA00413NP_0351592F10 RpL3 70%68%Spodoptera frugiperdaMus musculusAAL62468AAH096553A10 RpL7A 55%60%Drosophila melanogasterMus musculusNP_511063A302413D10 Ribophorin I 57%50%Drosophila melanogasterMus musculusAAN71150BAC266793G9 RpS8 70%71%Spodoptera frugiperdaMus musculusAAL62472XP_1349043G10 RpL27A 42% Spodoptera frugiperda AAK9215851
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