GTMB 7 - Gene Therapy & Molecular Biology

Gascón-Irún et al: Gene therapy antiproliferative strategies against cardiovascular diseaseAcknowledgmentsWork in the laboratory of V. Andrés is partiallysupported by the Ministerio de Ciencia y Tecnología ofSpain (MCyT) and Fondo Europeo de Desarrollo Regional(grants SAF2001-2358 and SAF2002-1143), and fromInstituto de Salud Carlos III (ISCIII) (Red de CentrosC03/01). S. M. Sanz and M. Gascón are predoctoralfellows of the ISCIII and MCyT, respectively.ReferencesAbe, J, Zhou, W, Taguchi, J, Takuwa, N, Miki, K, Okazaki, H,Kurokawa, K, Kumada, M, and Takuwa, Y (1994).Suppression of neointimal smooth muscle cell accumulationin vivo by antisense cdc2 and cdk2 oligonucleotides in ratcarotid artery. Biochem Biophys Res Commun 198, 16-24.Ahn, JD, Morishita, R, Kaneda, Y, Kim, HS, Chang, YC, Lee,KU, Park, JY, Lee, HW, Kim, YH, and Lee, IK (2002a).Novel E2F decoy oligodeoxynucleotides inhibit in vitrovascular smooth muscle cell proliferation and in vivoneointimal hyperplasia. Gene Ther 9, 1682-1692.Ahn, JD, Morishita, R, Kaneda, Y, Lee, SJ, Kwon, KY, Choi,SY, Lee, KU, Park, JY, Moon, IJ, Park, JG, Yoshizumi, M,Ouchi, Y, and Lee, IK (2002b). Inhibitory effects of novelAP-1 decoy oligodeoxynucleotides on vascular smoothmuscle cell proliferation in vitro and neointimal formation invivo. Circ Res 90, 1325-1332.Aktas, H, Cai, H, and Cooper, GM (1997). Ras links growthfactor signaling to the cell cyle machinery via regulation ofcyclin D1 and the cdk inhibitor p27 KIP1 . Mol Cell Biol 17,3850-3857.Andrés, V (1998). Control of vascular smooth muscle cellgrowth and its implication in atherosclerosis and restenosis.Int J Molec Med 2, 81-89.Andrés, V, Ure_a, J, Poch, E, Chen, D, and Goukassian, D(2001). The role of Sp1 in the induction of p27 geneexpression in vascular smooth muscle cells in vitro and afterballoon angioplasty. Arterioscl Thromb Vasc Biol 21, 342-347.Aoki, M, Morishita, R, Matsushita, H, Hayashi, S, Nakagami, H,Yamamoto, K, Moriguchi, A, Kaneda, Y, Higaki, J, andOgihara, T (1999). Inhibition of the p53 tumor suppressorgene results in growth of human aortic vascular smoothmuscle cells. Potential role of p53 in regulation of vascularsmooth muscle cell growth. Hypertension 34, 192-200.Bai, H, Morishita, R, Kida, I, Yamakawa, T, Zhang, W, Aoki, M,Matsushita, H, Noda, A, Nagai, R, Kaneda, I, Higaki, J,Ogihara, T, Sawa, Y, and Matsuda, H (1998). Inhibition ofintimal hyperplasia after vein grafting by in vivo transfer ofhuman senescent cell-derived inhibitor-1 gene. Gene Ther 5,761-769.Bauters, C, and Isner, JM (1997). The biology of restenosis.Prog Cardiovasc Dis 40, 107-116.Bennett, MR, Anglin, S, McEwan, JR, Jagoe, R, Newby, AC,and Evan, GI (1994a). Inhibition of vascular smooth musclecell proliferation in vitro and in vivo by c-myc antisenseoligodeoxynucleotides. J Clin Invest 93, 820-828.Bennett, MR, Evan, GI, and Newby, AC (1994b). Deregulatedexpression of the c-myc oncogene abolishes inhibition ofproliferation of rat vascular smooth muscle cells by serumreduction, interferon-g, heparin, and cyclic nucleotideanalogues and induces apoptosis. Circ Res 74, 525-536.Biro, S, Fu, Y-M, Yu, Z-X, and Epstein, SE (1993). Inhibitoryeffects of antisense oligodeoxynucleotides targeting c-mycmRNA on smooth muscle cell proliferation and migration.Proc Natl Acad Sci U S A 90, 654-658.Bogoyevitch, MA (2000). Signalling via stress-activatedmitogen-activated protein kinases in the cardiovascularsystem. Cardiovasc Res 45, 826-842.Braun-Dullaeus, RC, Mann, MJ, Seay, U, Zhang, L, von DerLeyen, HE, Morris, RE, and Dzau, VJ (2001). Cell cycleprotein expression in vascular smooth muscle cells in vitroand in vivo is regulated through phosphatidylinositol 3-kinase and mammalian target of rapamycin. ArteriosclerThromb Vasc Biol 21, 1152-1158.Brown, KE, Kindy, MS, and Sonenshein, GE (1992). Expressionof the c-myb proto-oncogene in bovine vascular smoothmuscle cells. J Biol Chem 267, 4625-4630.Buchwald, AB, Wagner, AH, Webel, C, and Hecker, M (2002).Decoy oligodeoxynucleotide against activator protein-1reduces neointimal proliferation after coronary angioplasty inhypercholesterolemic minipigs. J Am Coll Cardiol 39, 732-738.Burgess, TL, Fisher, EF, Ross, SL, Bready, JV, Qian, YX,Bayewitch, LA, Cohen, AM, Herrera, CJ, Hu, SS, Kramer,TB, and et al. (1995). The antiproliferative activity of c-myband c-myc antisense oligonucleotides in smooth muscle cellsis caused by a nonantisense mechanism. Proc Natl Acad SciU S A 92, 4051-4055.Burrig, KF (1991). The endothelium of advanced arterioscleroticplaques in humans. Arterioscler Thromb 11, 1678-1689.Campan, M, Desgranges, C, Gadeau, A-P, Millet, D, and Belloc,F (1992). Cell cycle dependent gene expression in quiescent,stimulated, and asynchronously cycling arterial smoothmuscle cells in culture. J Cell Physiol 150, 493-500.Castellot, JJ, Cochran, DL, and Karnovsky, MJ (1985). Effect ofheparin on vascular smooth muscle cells. I. Cell metabolism.J Cell Physiol 124, 21-28.Castro, C, Díez-Juan, A, Cortés, MJ, and Andrés, V (2003).Distinct regulation of mitogen-activated protein kinases andp27 Kip1 in smooth muscle cells from different vascular beds.A potential role in establishing regional phenotypic variance.J Biol Chem 278, 4482-4490.Chang, MW, Barr, E, Lu, MM, Barton, K, and Leiden, JM(1995a). Adenovirus-mediated over-expression of thecyclin/cyclin-dependent kinase inhibitor, p21 inhibitsvascular smooth muscle cell proliferation and neointimaformation in the rat carotid artery model of balloonangioplasty. J Clin Invest 96, 2260-2268.Chang, MW, Barr, E, Seltzer, J, Jiang, Y, Nabel, GJ, Nabel, EG,Parmacek, MS, and Leiden, JM (1995b). Cytostatic genetherapy for vascular proliferative disorders with aconstitutively active form of the retinoblastoma geneproduct. Science 267, 518-522.Chavany, C, Connell, Y, and Neckers, L (1995). Contribution ofsequence and phosphorothioate content to inhibition of cellgrowth and adhesion caused by c-myc antisense oligomers.Mol Pharmacol 48, 738-746.Chen, D, Krasinski, K, Chen, D, Sylvester, A, Chen, J, Nisen,PD, and Andrés, V (1997). Downregulation of cyclindependentkinase 2 activity and cyclin A promoter activity invascular smooth muscle cells by p27 Kip1 , an inhibitor ofneointima formation in the rat carotid artery. J Clin Invest99, 2334-2341.Claudio, PP, Fratta, L, Farina, F, Howard, CM, Stassi, G,Numata, S, Pacilio, C, Davis, A, Lavitrano, M, Volpe, M,Wilson, JM, Trimarco, B, Giordano, A, and Condorelli, G(1999). Adenoviral RB2/p130 gene transfer inhibits smoothmuscle cell proliferation and prevents restenosis afterangioplasty. Circ Res 85, 1032-1039.Cohen-Sacks, H, Najajreh, Y, Tchaikovski, V, Gao, G, Elazer, V,Dahan, R, Gati, I, Kanaan, M, Waltenberger, J, and Golomb,G (2002). Novel PDGFbetaR antisense encapsulated in84