GTMB 7 - Gene Therapy & Molecular Biology

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Gascón-Irún et al: Gene therapy antiproliferative strategies against cardiovascular diseaseAcknowledgmentsWork in the laboratory of V. Andrés is partiallysupported by the Ministerio de Ciencia y Tecnología ofSpain (MCyT) and Fondo Europeo de Desarrollo Regional(grants SAF2001-2358 and SAF2002-1143), and fromInstituto de Salud Carlos III (ISCIII) (Red de CentrosC03/01). S. M. Sanz and M. Gascón are predoctoralfellows of the ISCIII and MCyT, respectively.ReferencesAbe, J, Zhou, W, Taguchi, J, Takuwa, N, Miki, K, Okazaki, H,Kurokawa, K, Kumada, M, and Takuwa, Y (1994).Suppression of neointimal smooth muscle cell accumulationin vivo by antisense cdc2 and cdk2 oligonucleotides in ratcarotid artery. Biochem Biophys Res Commun 198, 16-24.Ahn, JD, Morishita, R, Kaneda, Y, Kim, HS, Chang, YC, Lee,KU, Park, JY, Lee, HW, Kim, YH, and Lee, IK (2002a).Novel E2F decoy oligodeoxynucleotides inhibit in vitrovascular smooth muscle cell proliferation and in vivoneointimal hyperplasia. Gene Ther 9, 1682-1692.Ahn, JD, Morishita, R, Kaneda, Y, Lee, SJ, Kwon, KY, Choi,SY, Lee, KU, Park, JY, Moon, IJ, Park, JG, Yoshizumi, M,Ouchi, Y, and Lee, IK (2002b). Inhibitory effects of novelAP-1 decoy oligodeoxynucleotides on vascular smoothmuscle cell proliferation in vitro and neointimal formation invivo. Circ Res 90, 1325-1332.Aktas, H, Cai, H, and Cooper, GM (1997). Ras links growthfactor signaling to the cell cyle machinery via regulation ofcyclin D1 and the cdk inhibitor p27 KIP1 . Mol Cell Biol 17,3850-3857.Andrés, V (1998). Control of vascular smooth muscle cellgrowth and its implication in atherosclerosis and restenosis.Int J Molec Med 2, 81-89.Andrés, V, Ure_a, J, Poch, E, Chen, D, and Goukassian, D(2001). The role of Sp1 in the induction of p27 geneexpression in vascular smooth muscle cells in vitro and afterballoon angioplasty. 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Cytostatic genetherapy for vascular proliferative disorders with aconstitutively active form of the retinoblastoma geneproduct. Science 267, 518-522.Chavany, C, Connell, Y, and Neckers, L (1995). Contribution ofsequence and phosphorothioate content to inhibition of cellgrowth and adhesion caused by c-myc antisense oligomers.Mol Pharmacol 48, 738-746.Chen, D, Krasinski, K, Chen, D, Sylvester, A, Chen, J, Nisen,PD, and Andrés, V (1997). Downregulation of cyclindependentkinase 2 activity and cyclin A promoter activity invascular smooth muscle cells by p27 Kip1 , an inhibitor ofneointima formation in the rat carotid artery. J Clin Invest99, 2334-2341.Claudio, PP, Fratta, L, Farina, F, Howard, CM, Stassi, G,Numata, S, Pacilio, C, Davis, A, Lavitrano, M, Volpe, M,Wilson, JM, Trimarco, B, Giordano, A, and Condorelli, G(1999). Adenoviral RB2/p130 gene transfer inhibits smoothmuscle cell proliferation and prevents restenosis afterangioplasty. 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Gene Therapy and Molecular Biology Vol 7, page 85polymeric nanospheres for the treatment of restenosis. GeneTher 9, 1607-1616.Condorelli, G, Aycock, JK, Frati, G, and Napoli, C (2001).Mutated p21/WAF/CIP transgene overexpression reducessmooth muscle cell proliferation, macrophage deposition,oxidation-sensitive mechanisms, and restenosis inhypercholesterolemic apolipoprotein E knockout mice.FASEB J 15, 2162-2170.Cortés, MJ, Díez-Juan, A, Pérez, P, Pérez-Roger, I, Arroyo-Pellicer, R, and Andrés, V (2002). Increased earlyatherogenesis in young versus old hypercholesterolemicrabbits by a mechanism independent of arterial cellproliferation. FEBS Letters 522, 99-103.Dartsch, PC, Voisard, R, Bauriedel, G, Hofling, B, and Betz, E(1990). Growth characteristics and cytoskeletal organizationof cultured smooth muscle cells from human primarystenosing and restenosing lesions. Arteriosclerosis 10, 62-75.Díez-Juan, A, and Andrés, V (2001). The growth suppressorp27 Kip1 protects against diet-induced atherosclerosis. FASEBJ 15, 1989-1995.Dyson, N (1998). The regulation of E2F by pRB-family proteins.Genes Dev 12, 2245-2262.Dzau, VJ, Braun-Dullaeus, RC, and Sedding, DG (2002).Vascular proliferation and atherosclerosis: new perspectivesand therapeutic strategies. Nat Med 8, 1249-1256.Ebbecke, M, Unterberg, C, Buchwald, A, Stohr, S, and Wiegand,V (1992). Antiproliferative effects of a c-myc antisenseoligonucleotide on human arterial smooth muscle cells. BasicRes Cardiol 87, 585-591.Ehsan, A, Mann, MJ, Dell'Acqua, G, and Dzau, VJ (2001).Long-term stabilization of vein graft wall architecture andprolonged resistance to experimental atherosclerosis afterE2F decoy oligonucleotide gene therapy. J ThoracCardiovasc Surg 121, 714-722.Essed, CE, Van den Brand, M, and Becker, AE (1983).Transluminal coronary angioplasty and early restenosis.Fibrocellular occlusion after wall laceration. 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Phosphorothioate oligodeoxynucleotidesbind to basic fibroblast growth factor, inhibit its binding tocell surface receptors, and remove it from low affinitybinding sites on extracellular matrix. J Biol Chem 270,2620-2627.Hu, WY, Fukuda, N, Kishioka, H, Nakayama, M, Satoh, C, andKanmatsuse, K (2001a). Hammerhead ribozyme targetinghuman platelet-derived growth factor A- chain mRNAinhibited the proliferation of human vascular smooth musclecells. Atherosclerosis 158, 321-329.Hu, WY, Fukuda, N, Nakayama, M, Kishioka, H, andKanmatsuse, K (2001b). Inhibition of vascular smoothmuscle cell proliferation by DNA-RNA chimerichammerhead ribozyme targeting to rat platelet-derivedgrowth factor A-chain mRNA. J Hypertens 19, 203-212.Hu, Y, Cheng, L, Hochleitner, BW, and Xu, Q (1997). Activationof mitogen-activated protein kinases (ERK/JNK) and AP-1transcription factor in rat carotid arteries after balloon injury.Arterioscler Thromb Vasc Biol 17, 2808-2816.Hu, Y, Dietrich, H, Metzler, B, Wick, G, and Xu, Q (2000).Hyperexpression and activation of extracellular signalregulatedkinases (ERK1/2) in atherosclerotic lesions ofcholesterol-fed rabbits. Arterioscler Thromb Vasc Biol 20,18-26.Iacopetta, B, Wysocki, S, Norman, P, and House, A (1995). Thep53 tumor suppressor gene is overexpressed but not mutatedin human atherosclerotic tissue. Int J Oncol 7, 399-402.Ihling, C, Menzel, G, Wellens, E, Monting, JS, Schaefer, HE,and Zeiher, AM (1997). Topographical association betweenthe cyclin-dependent kinases inhibitor p21, p53accumulation, and cellular proliferation in humanatherosclerotic tissue. Arterioscler Thromb Vasc Biol 17,2218-2224.Ihling, C, Technau, K, Gross, V, Schulte-Monting, J, Zeiher,AM, and Schaefer, HE (1999). Concordant upregulation oftype II-TGF-beta-receptor, the cyclin- dependent kinasesinhibitor p27 Kip1 and cyclin E in human atherosclerotic tissue:implications for lesion cellularity. Atherosclerosis 144, 7-14.Indolfi, C, Avvedimento, EV, Rapacciuolo, A, Di Lorenzo, E,Esposito, G, Stabile, E, Feliciello, A, Mele, E, Giuliano, P,Condorelli, G, and Chiariello, M (1995). Inhibition ofcellular ras prevents smooth muscle cell proliferation aftervascular injury in vivo. Nature Med 1, 541-545.Isner, JM (1994). Vascular remodeling. Honey, I think I shrunkthe artery. Circulation 89, 2937-2941.Izumi, Y, Kim, S, Namba, M, Yasumoto, H, Miyazaki, H,Hoshiga, M, Kaneda, Y, Morishita, R, Zhan, Y, and Iwao, H(2001). Gene transfer of dominant-negative mutants ofextracellular signal- regulated kinase and c-Jun NH2-terminal kinase prevents neointimal formation in ballooninjuredrat artery. Circ Res 88, 1120-1126.Katsuda, S, Coltrera, MD, Ross, R, and Gown, AM (1993).Human atherosclerosis. IV. Immunocytochemical analysis ofcell activation and proliferation in lesions of young adults.Am J Pathol 142, 1787-1793.Kawauchi, M, Suzuki, J, Morishita, R, Wada, Y, Izawa, A,Tomita, N, Amano, J, Kaneda, Y, Ogihara, T, Takamoto, S,and Isobe, M (2000). Gene therapy for attenuating cardiacallograft arteriopathy using ex vivo E2F decoy transfectionby HVJ-AVE-liposome method in mice and nonhumanprimates. Circ Res 87, 1063-1068.85
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