Sabato 27 ottobre 2012 - Pacini Editore

More documents

Recommendations

Info

312 Fig. 3. β-hCG (a) and HER-2 (B) showed a positive reaction in syncytiotrophoblast-like cells (10x magnification). references 1 Civantos F, Rywlin A. Carcinomas with trophoblastic differentiation and secretion of chorionic gonadotrophins. Cancer 1972;29:689-798. 2 Akbulut M, Tosun H, Soysal ME. Endometrioid carcinoma of the endometrium with choriocarcinomatous differentiation: a case report and review of the literature. Obstet Gynecol Oztekin O Arch 2008;278:79-84. 3 Yamada T, Mori H, Kanemura M. et al. Endometrial carcinoma with choriocarcinomatous differentiation: a case report and review of the literature. Gynecol Oncol 2009;113:291-4. 4 Akbulut M, Tosun H, Soysal ME, et al. Endometrioid carcinoma of the endometrium with choriocarcinomatous differentiation: a case report and review of the literature. Arch Gynecol Obstet 2008;278:79-84. 5 Horn LC, Hanel C, Bartholdt E, et al. Serous carcinoma of the endometrium with choriocarcinomatous differentiation: a case report and review of the literature indicate the existence of 2 prognostically relevant tumor types. Int J Gynecol Pathol 2006;25:247-51. 6 Patil S, Ramakrishna KA, Rao SG, et al. Choriocarcinoma - a rare association with squamous cell carcinoma of esophagus. Indian J Gastroenterol 2006;25:42-3. 7 Dennis PM, Turner AG. Primary choriocarcinoma of the bladder evolving from a transitional cell carcinoma. J Clin Pathol 1984;37:503-5. 8 Grammatico D, Grignon DJ, Eberwein P, et al. Transitional cell carcinoma of the renal pelvis with choriocarcinomatous differentiation. Immunohistochemical and immunoelectron microscopic assessment of human chorionic gonadotropin production by transitional cell carcinoma of the urinary bladder. Cancer 1993;71:1835-41. 9 Yoon JH, Kim MS, Kook EH, et al. Primary gastric choriocarcinoma: two case reports and review of the literatures. Cancer Res Treat 2008;40:145-50. 10 Verbeek W, Schulten HJ, Sperling M, et al. Rectal adenocarcinoma with choriocarcinomatous differentiation: clinical and genetic aspects. Hum Pathol 2004;35:1427-30. 11 Chen F, Tatsumi A, Numoto S. Combined choriocarcinoma and adenocarcinoma of the lung occurring in a man: case report and review of the literature. Cancer 2001;91:123-9. 12 Erhan Y, Ozdemir N, Zekioglu O, et al. Breast carcinomas with choriocarcinomatous features: case reports and review of the literature. Breast J 2002;8:244-8. 13 Maesta I, Michelin OC, Traiman P, et al. Primary non-gestational choriocarcinoma of the uterine cervix: a case report. Gynecol Oncol 2005;98:146-50. 14 Schwab KE, Chan RW, Gargett CE. Putative stem cell activity of human endometrial epithelial and stromal cells during the menstrual cycle. Fertil Steril 2005;84(Suppl. 2):1124-30. Adenomatoid tumor of the uterus: a case report of a rare benign entity G. Crisman1 , I. Cicchinelli1 , A.R. Vitale2 , G. Coletti3 , S. Di Rito1 , F. Patacchiola4 , G. Carta5 , P. Leocata1 1 Anatomia Patologica, Dipartimento di Scienze della Salute, Università dell’Aquila, L’Aquila, Italia; 2 U.O.C. Anatomia Patologica, P.O. “SS Filippo e Nicola”, Avezzano (AQ), Italia; 3 U.O.C. Anatomia Patologica Ospedale Civile “San Salvatore”, L’Aquila, Italia; 4 U.O.C. Ginecologia ed Ostetricia, Ospedale “Val Vibrata”, Sant’Omero (TE), Italia; 5 U.O.C. Ginecologia ed Ostetricia D.U., Università dell’Aquila, L’Aquila, Italia Background. First described by Golden and Ash in 1945, Adenomatoid Tumor represents a benign neoplasm occurring most CONGRESSO aNNualE di aNatOmia patOlOGiCa SiapEC – iap • fiRENzE, 25-27 OttOBRE 2012 Fig. 1. Histological features of the lesion: revealed prominent fascicles of smooth muscle with scattered cuboidal and signet ring-like cells with an optical white, scant cytoplasm (a: H&E, 10x magnification; B: H&E, 20x magnification). frequently in the epididymis in males and the fallopian tubes in females. According to the literature, less frequently adenomatoid tumor occurs in the uterus, with an incidence of only 10 in 8000 hysterectomy specimens in one series. The histogenesis of the adenomatoid tumor is still debatable, but recently a mesothelial origin has been proved by ultrastructural and immunohistochemical studies. Material and methods. We experienced a case of an adenomatoid tumor in a 32-year-old woman who presented to the Gynaecological Department with an uterine mass of 2,5 cm in-diameter. Clinical diagnosis of a myomatous nodule was posed and the mass has been surgically removed and sent to the Pathology Unit. Grossly, the nodule presented as a whitish, rounded mass, of hard-elastic consistency, measuring 2,5x2,5x1,3 cm. Results. Histological features of the lesion revealed prominent fascicles of smooth muscle with scattered cuboidal and signet ring-like cells with an optical white, scant cytoplasm. Mild nuclear atypia of these cells and low mitotic activity was observed as well. The tumor cells positively expressed CK AE1/ AE3, Calretinin, and D2-40, and did not express alpha-inhibitin and Melan-A. The prominent smooth muscle component strongly stained for Actin. Thus, a diagnosis of Adenomatoid Tumor was posed. Conclusions. The characteristic histopathological features usually lead to the correct diagnosis in the majority of adenomatoid tumors. However, several unusual features may result in a di- Fig. 2. a. tumor cells strongly stained for Calretinin (Calretinin, 10x magnification). B. tumor cells strongly stained for Cytokeratin aE1/ aE3 (CK aE1/aE3, 20x magnification). Fig. 3. a. tumor cells strongly stained for d2-40 (d2-40, 20x magnification). B: the prominent smooth muscle component strongly stained for actin (actin, 10x magnification).
COmuNiCaziONi ORali agnostic challenge. As in the present case, a prominent smooth muscle component with only scattered tumor cells may be mistaken for a leiomyoma, even though an association between adenomatoid tumors and leiomyomas seem to be not uncommon. Moreover, adenomatoid tumors with a solid growth pattern or cords of cells may be mistaken for an infiltrating malignant epithelial or mesothelial neoplasm. A differential diagnosis with a signet ring cell adenocarcinoma should be considered when small cells with small vacuoles are observed. In conclusion, we underline the importance to investigate each gynaecological lesion with great attention, in the aim to avoid over or under treatment in such challenging cases. references 1 Goddard MJ, Grant JW. Adenomatoid tomours; a mucin histochemical and immunohistochemical study. Histopathology 1992;20:57-71. 2 Nogales FF, Isaac MA, Hardisson D, et al. Adenomatoid tumors of the uterus: an analysis of 60 cases. Int J Gynecol Pathol 2001;21:34-40. 3 Quigley JC, Hart WR. Adenomatoid tumors of the uterus. Am J Clin Pathol 1981;76:627-35. 4 Young RH, Silva EG, Scully RE. Ovarian and juxtaovarian adenomatoid tumors: a report of six cases. Int J Gynecol Pathol 1991;10:364- 72. 5 Amre R, Constantino J, Lu S, et al. Pathologic quiz case: a 52-yearold woman with a uterine mass. Arch Pathol Lab Med 2005;129:77-8. 6 Skinnider BF, Young RH. Infarcted adenomatoid tumor; a report of five cases of a facet of a benign neoplasm that may cause diagnostic difficulty. Am J Surg Pathol 2004;28:77-83. 7 Epstein JI. Urologic disorders: Differential Diagnosis in Pathology. New York, NY: Igasku-Shoin 1992, pp. 173-4. 8 Golden A, Ash JE. Adenomatoid tumors of the genital tract. Am J Pathol 1945;21:63-79. 9 Tiltman AJ. Adenomatoid tumors of the uterus and adnexa. Histopathology 1980;4:437-43. 10 Hes O, Perez-Montiel P, Alvarado Cabrer I, et al. Thread-like bridging strands: a morphologic feature present in all adenomatoid tumors. Ann Diagn Pathol 2003;7:273-7. 11 Phillips V, McCluggage WG, Young RH. Oxyphilic adenomatoid tumor of the ovary: a case report with discussion of the differential diagnosis of ovarian tumors with vacuoles and related spaces. Int J Gynecol Pathol 2007;26:16-20. 12 Irikoma M, Takahashi K, Kurioka H, et al. Uterine adenomatoid tumors confirmed by immunohistochemical staining. Arch Gynecol Obstet 2001;265:151-4. 13 Palacios J, Manrique AS, Villaespesa AR, et al. Cystic adenomatoid tumor of the uterus. Int J Gynecol Pathol 1991;10:296-301. A new monoclonal antibody kit for detecting HPV E7 oncoprotein: could it be a suitable, specific biomarker for hpv infection in cervical biopsies? G. Crisman1 , A.R. Vitale2 , L. Sollima1 , S. Bonin3 , V. Ciuffetelli4 , A. Dal Mas4 , S. Saltarelli4 , L. Muzzolini5 , P. Zago5 , P. Leocata1 1 Anatomia Patologica, Dipartimento di Scienze della Salute, Università dell’Aquila, L’Aquila, Italia; 2 U.O.C. Anatomia Patologica, P.O. “SS. Filippo e Nicola”, Avezzano (AQ), Italia; 3 Dip. Univ. Cl. di Scienze Mediche, Chirurgiche e della Salute, Università di Trieste, Trieste, Italia; 4 U.O.C. Anatomia Patologica, Ospedale Civile “San Salvatore”, L’Aquila, Italia; 5 Adriacell SpA, Trieste, Italia Introduction. The association of human papilloma virus (HPV) infection and cervical intraepithelial neoplasia (CIN) is well recognized. High-risk human papillomavirus (HR-HPV) infection are responsible of the vast majority of CINs and cervical carcinomas (CC) whereas the low-risk HPV(LR-HPV) types are rarely found. The different oncogenic potential of HR-HPV and LR-HPV is due to the different interactions of two major viral oncoproteins, E6 and E7, with cellular regulatory proteins, p53 and pRb. Interaction of HPV E6 and E7 oncogenic proteins with key regulatory cellular proteins leads to up regulation of p16INK4a , a CDK inhibitor. The overexpression of p16INK4a represents nowadays an indirect immunohistochemical marker for HPV infection, even 313 Fig. 1. HpV E7 viral oncoprotein expression in CiN1 (a), CiN2 (B) and CiN3(C) lesions. the expression strongly correlates with the grade of ciN though p16 INK4a -negative CINs and CCs are described. Thus, a more specific biomarker for HPV infection is needed. We investigated the expression of a new immunohistochemical monoclonal antibody kit which detects high-risk E7 oncogenic proteins of the Alpha-Papillomavirus genus (species 5,6,7 and 9) and compared the results with the p16 INK4a expression in CINs. Material and methods. Retrospective analysis of 50 paraffinembedded samples of diagnostic biopsies and surgical materials was performed by immunohistochemistry using commercially Fig. 2. a 20-year old woman with a pap smear diagnosis of l-Sil. Histological features of the cervical biopsy revealed a CiN1 lesion (a), p16 negative (B), HpV E7 viral oncoprotein positive (C). pCR investigations confirmed the presence of HpV 31 dNa.
Page 1 and 2:
Periodico bimestrale - POSTE ITALIA
Page 3:
VENTANA iScan HT Riconcepire le imm
Page 6:
Information for Authors including e
Page 10 and 11:
08.30 - 10.30 10.30 - 11.30 Sala DO
Page 12 and 13:
202 gli attuali approcci multidimen
Page 14 and 15:
204 of Florence, University of Pisa
Page 16 and 17:
206 rare tumors with various biolog
Page 18 and 19:
208 died of disease. Incomplete res
Page 20 and 21:
210 were included in order to explo
Page 22 and 23:
212 Key words: EGC, Prognosis, Trea
Page 24 and 25:
214 Tab. VI. univariate analysis: 5
Page 26 and 27:
216 the surgeons perform a pancreat
Page 28 and 29:
218 Tab. I. RB-ILD DIP LCH olitis (
Page 30 and 31:
220 ciation of Medical Oncology (AI
Page 32 and 33:
222 and CD56 are the best immunosta
Page 34 and 35:
224 by the general pathologist [1.8
Page 36 and 37:
226 na illuminazione, da un vulvolo
Page 38 and 39:
228 9 Lynch PJ, Moyal-Barocco M, Bo
Page 40 and 41:
230 Procedure di analisi del linfon
Page 42 and 43:
232 are classified as G1 NETs, foll
Page 44 and 45:
234 31 Nugent SL, Cunningham SC, Al
Page 46 and 47:
236 mas and leukemias, whereas the
Page 48 and 49:
238 Patobiologia della parete aorti
Page 50 and 51:
240 10 Luo BH, Carman CV, Springer
Page 52 and 53:
242 zienti asintomatici, la sede pi
Page 54 and 55:
244 Anatomia patologica e citopatol
Page 56 and 57:
246 Fig. 1 logico o cell-blocks, co
Page 58 and 59:
248 In ductal carcinoma the cytolog
Page 60 and 61:
250 techniques have resulted in the
Page 62 and 63:
252 Predictive factors in colorecta
Page 64 and 65:
254 to che ha l’obiettivo di perm
Page 66 and 67:
256 Quanto ai mediatori, in caso di
Page 68 and 69:
258 L’incidenza media complessiva
Page 70 and 71:
260 Anatomia Patologica scegliere q
Page 72 and 73: 262 assessment of adequacy, because
Page 74 and 75: 264 paese ed il nostro SSN, di fatt
Page 77 and 78: patHOlOGiCa 2012;104:267-358 COMUnI
Page 79 and 80: COmuNiCaziONi ORali Solitary T-cell
Page 81 and 82: COmuNiCaziONi ORali differences in
Page 83 and 84: COmuNiCaziONi ORali Tab. I. CYTOLOG
Page 85 and 86: COmuNiCaziONi ORali BrAF mutation a
Page 87 and 88: COmuNiCaziONi ORali The aim of the
Page 89 and 90: COmuNiCaziONi ORali Tab. I. R-MSFTs
Page 91 and 92: COmuNiCaziONi ORali Fig. 1. skin us
Page 93 and 94: COmuNiCaziONi ORali complications.
Page 95 and 96: COmuNiCaziONi ORali Immunohistochem
Page 97 and 98: COmuNiCaziONi ORali advanced pathol
Page 99 and 100: COmuNiCaziONi ORali Fig. 4. tCRGd+c
Page 101 and 102: COmuNiCaziONi ORali LOH analysis of
Page 103 and 104: COmuNiCaziONi ORali Tab. I. distrib
Page 105 and 106: COmuNiCaziONi ORali in the leading
Page 107 and 108: COmuNiCaziONi ORali Conclusions. Sp
Page 109 and 110: COmuNiCaziONi ORali kidney) is unpr
Page 111 and 112: COmuNiCaziONi ORali 7 Ellis I. Qual
Page 113 and 114: COmuNiCaziONi ORali A case of intra
Page 115 and 116: COmuNiCaziONi ORali progress, recur
Page 117 and 118: COmuNiCaziONi ORali Fig. 3 referenc
Page 119 and 120: COmuNiCaziONi ORali Results. Expres
Page 121: COmuNiCaziONi ORali GEnITALE MASCHI
Page 125 and 126: COmuNiCaziONi ORali Fig. 1. ultraso
Page 127 and 128: COmuNiCaziONi ORali evaluation that
Page 129 and 130: COmuNiCaziONi ORali PLAP in normal
Page 131 and 132: COmuNiCaziONi ORali or identificati
Page 133 and 134: COmuNiCaziONi ORali references 1 Ro
Page 135 and 136: COmuNiCaziONi ORali patients who ha
Page 137 and 138: COmuNiCaziONi ORali Tab. II. TCGC-S
Page 139 and 140: COmuNiCaziONi ORali and hindgut ori
Page 141 and 142: COmuNiCaziONi ORali plastic disease
Page 143 and 144: COmuNiCaziONi ORali antibodies prio
Page 145 and 146: COmuNiCaziONi ORali edema following
Page 147 and 148: COmuNiCaziONi ORali Fig. 3. fibroma
Page 149 and 150: COmuNiCaziONi ORali microarray anal
Page 151 and 152: COmuNiCaziONi ORali True 3q chromos
Page 153 and 154: COmuNiCaziONi ORali To our knowledg
Page 155 and 156: COmuNiCaziONi ORali segment, at the
Page 157 and 158: COmuNiCaziONi ORali defined as “n
Page 159 and 160: COmuNiCaziONi ORali TESTA COLLO Lym
Page 161 and 162: COmuNiCaziONi ORali references 1 Sa
Page 163 and 164: COmuNiCaziONi ORali of the paranasa
Page 165 and 166: COmuNiCaziONi ORali general dental
Page 167 and 168: COmuNiCaziONi ORali P16 immunohisto
Page 169 and 170: Pathologica 2012;104:359-420 POSTEr
Page 171 and 172: PoStER references 1 Gerber DE, Minn
Page 173 and 174:
PoStER In our case the endofibrotic
Page 175 and 176:
PoStER Fig. 1. Kaplan-meier surviva
Page 177 and 178:
PoStER believed the use of atypical
Page 179 and 180:
PoStER references 1 Goepel JR. Beni
Page 181 and 182:
PoStER MALT lymphoma of the rectum:
Page 183 and 184:
PoStER 3 Ciulla A, Castronovo G, To
Page 185 and 186:
PoStER for protein expression of PA
Page 187 and 188:
PoStER the better one because the m
Page 189 and 190:
PoStER Grossly, an irregular villou
Page 191 and 192:
PoStER Expression of ror-1 in pancr
Page 193 and 194:
PoStER (see Fig. 1) placental site
Page 195 and 196:
PoStER Tissue were fixed in 10% for
Page 197 and 198:
PoStER invaded focally adjacent tun
Page 199 and 200:
PoStER bination chemotherapy the pr
Page 201 and 202:
PoStER 21 to 55 years in age, the l
Page 203 and 204:
PoStER Results and conclusion. We a
Page 205 and 206:
PoStER Identification of cancer ste
Page 207 and 208:
PoStER Epidemiological and biomolec
Page 209 and 210:
PoStER Fig. 1. ductal invasive Brea
Page 211 and 212:
PoStER Fig. 2. Fig. 3. Fig. 4. Conc
Page 213 and 214:
PoStER monly develops in elderly ad
Page 215 and 216:
PoStER haematoxylin and eosin and V
Page 217 and 218:
PoStER Fig. 4. High mitotic rate (a
Page 219 and 220:
PoStER Fig. 6. focal sebaceous and
Page 221 and 222:
PoStER Results. At gross examinatio
Page 223 and 224:
PoStER strated that HPV is present
Page 225 and 226:
PoStER Fig. 1. EE primary intestina
Page 227 and 228:
PoStER Introduction. Angiosarcoma i
Page 229 and 230:
PoStER 9 Klein KA, Stephens DH, Wel
Page 231 and 232:
Pathologica 2012;104:421-423 InDICE
Page 233:
iNDicE DEgli aUtoRi Orsaria M., 319
show all

Sabato 27 ottobre 2012 - Pacini Editore

Create successful ePaper yourself

Delete template?

Save as template?