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Sabato 27 ottobre 2012 - Pacini Editore

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342<br />

3 Soda M, et al. Identification of the transforming EML4-ALK fusion<br />

gene in non-small-cell lung cancer. Nature 2007;448:561-6.<br />

4 Soda M, et al. A mouse model for EML4-ALK-positive lung cancer.<br />

Proc Natl Acad Sci USA 2008;105:19893-7.<br />

5 Shaw AT, et al. Clinical features and outcome of patients with<br />

non-small-cell lung cancer who harbor EML4-ALK. J Clin Oncol<br />

2009;<strong>27</strong>:4247-53.<br />

6 Kwak EL, et al. Anaplastic lymphoma kinase inhibition in non-smallcell<br />

lung cancer. N Engl J Med;363:1693-703.<br />

7 Chaft JE, et al. ALK-Rearranged Lung Cancer: Adenosquamous Lung<br />

Cancer Masquerading as Pure Squamous Carcinoma. J Thorac Oncol;7:768-9.<br />

8 Klempner SJ, et al. ALK translocation in non-small cell lung cancer<br />

with adenocarcinoma and squamous cell carcinoma markers. J Thorac<br />

Oncol;6:1439-40.<br />

9 Kimura H, et al. ALK fusion gene positive lung cancer and 3<br />

cases treated with an inhibitor for ALK kinase activity. Lung Cancer;75:66-72.<br />

10 Solomon B, et al. ALK gene rearrangements: a new therapeutic target<br />

in a molecularly defined subset of non-small cell lung cancer. J Thorac<br />

Oncol 2009;4:1450-4.<br />

11 Inamura K, et al. EML4-ALK lung cancers are characterized by rare<br />

other mutations, a TTF-1 cell lineage, an acinar histology, and young<br />

onset. Mod Pathol 2009;22:508-15.<br />

12 Jokoji R, et al. Combination of morphological feature analysis and<br />

immunohistochemistry is useful for screening of EML4-ALK-positive<br />

lung adenocarcinoma. J Clin Pathol;63:1066-70.<br />

13 Rodig SJ, et al. Unique clinicopathologic features characterize ALKrearranged<br />

lung adenocarcinoma in the western population. Clin<br />

Cancer Res 2009;15:5216-23.<br />

14 Boland JM, et al. Anaplastic lymphoma kinase immunoreactivity correlates<br />

with ALK gene rearrangement and transcriptional up-regulation<br />

in non-small cell lung carcinomas. Hum Pathol 2009;40:1152-8.<br />

15 Yoshida A, et al. Comprehensive histologic analysis of ALK-rearranged<br />

lung carcinomas. Am J Surg Pathol;35:1226-34.<br />

16 Paik JH, et al. Screening of anaplastic lymphoma kinase rearrangement<br />

by immunohistochemistry in non-small cell lung cancer: correlation<br />

with fluorescence in situ hybridization. J Thorac Oncol;6:466-72.<br />

17 Lee JK, et al. Comparative analyses of overall survival in patients with<br />

anaplastic lymphoma kinase-positive and matched wild-type advanced<br />

nonsmall cell lung cancer. Cancer.<br />

18 Wong DW, et al. The EML4-ALK fusion gene is involved in various<br />

histologic types of lung cancers from nonsmokers with wild-type<br />

EGFR and KRAS. Cancer 2009;115:1723-33.<br />

19 Martelli MP, et al. EML4-ALK rearrangement in non-small cell lung<br />

cancer and non-tumor lung tissues. Am J Pathol 2009;174:661-70.<br />

20 Takeuchi K, et al. KIF5B-ALK, a novel fusion oncokinase identified by<br />

an immunohistochemistry-based diagnostic system for ALK-positive<br />

lung cancer. Clin Cancer Res 2009;15:3143-9.<br />

21 Just PA, et al. Histologic subtypes, immunohistochemistry, FISH or<br />

molecular screening for the accurate diagnosis of ALK-rearrangement<br />

in lung cancer: A comprehensive study of Caucasian non-smokers.<br />

Lung Cancer.<br />

22 Koh PK, et al. Targeted agents in non-small cell lung cancer<br />

(NSCLC): Clinical developments and rationale for the combination<br />

with thoracic radiotherapy. Cancer Treat Rev.<br />

23 Inamura K et al. EML4-ALK fusion is linked to histological characteristics<br />

in a subset of lung cancers. J Thorac Oncol 2008;3:13-7.<br />

An unexpected diagnosis of clear cell renal cell<br />

carcinoma after wedge lung resection<br />

L. Gnetti1 , R. Manuguerra1 , F. Brigati1 , F.P. Pilato1 , L. Ampollini2<br />

, E.M. Silini1 1 Azienda Ospedaliero-Universitaria di Parma, Dipartimento Onco-Ematologico<br />

Internistico, Sezione di Anatomia Patologica; 2 Azienda Ospedaliero-Universitaria<br />

di Parma, Dipartimento Cardio-Nefro-Polmonare,<br />

Sezione di Chirurgia Toracica<br />

Introduction. Simultaneous presentation of two different primary<br />

malignancy from different sites is known as “collision tumor”.<br />

The same phenomenon is possible, but very rare, in limph nodes<br />

(“collision metastasis”).<br />

Carcinoma metastasizing to lymph nodes cointening a lymphoproliferative<br />

disorders has also been reported.<br />

CONGRESSO aNNualE di aNatOmia patOlOGiCa SiapEC – iap • fiRENzE, 25-<strong>27</strong> OttOBRE <strong>2012</strong><br />

Fig. 1.<br />

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Fig. 3.

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