Sabato 27 ottobre 2012 - Pacini Editore

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Fig. 1. Extensive erythematous plaque lesion, 7x5cm sized, with verrucous
and hyperkeratotic surface, centrally ulcerated, sharp margins
and slightly infiltrated. (insert: slightly elevated brownish reddish
tumour with an erosive surface. H&E 4X).
Fig. 2. at the periphery of the tumours anastomosing lobules of small
uniform cuboidal poroid cells with focal ductal structures (intracitoplasmic
lumina formation) had proliferated in the upper third of the
dermis (h&E 10X).
Fig. 3. the poroma component consisted of atypical cuboidal cells
with oval nuclei, scant cytoplasm, intercellular bridges and small
round ductal structures (h&E 20X).
CONGRESSO aNNualE di aNatOmia patOlOGiCa SiapEC – iap • fiRENzE, 25-27 OttOBRE 2012
ponent consisted of atypical cuboidal cells with oval nuclei, scant
cytoplasm, intercellular bridges and small round ductal structures
(Fig. 3). The ductal component is constituted by ducts with lumina
of variable size, lined by cells with intensely cuticular eosinophilic
cytoplasm. “Decapitation” secretion was evident with
intraluminal amorphous eosinophilic material (Fig. 4). Clear cell
change was found and consisted of ample cytoplasm, hiperchromatic,
irregular nuclei. These cells contained abundant amount of
glycogen (Fig. 5). Focal sebaceous and follicular differentiation
was present (Fig. 6). The comedonecrosis island of tumour cells
contained central areas of neoplastic cell death with inflammatory
debris (Fig. 7). Lymphovascular invasion was absent. Distinct
neovascularization and an infiltrate of inflammatory cells could
be seen all around the tumour.
Discussion. Benign cutaneous appendage tumours are common
and it is surprising that their malignant counterparts are exceedingly
rare. Traditionally poroid neoplasms have been classified
as eccrine tumours, relating to the intraepidermal eccrine coil
epithelium. Poroid neoplasms may show different differentiation,
reflecting the embryological association of follicular sebaceous
and ductal structures (folliculosebaceous apocrine units). In
1963 Pinkus and Mehregan 2 described the first case of eccrine
Fig. 4. “decapitation” secretion was evident with intraluminal amorphous
eosinophilic material (H&E 20X).
Fig. 5. the neoplastic cells contained glycogen (H&E 10X).