Growth, Differentiation and Sexuality

328 S. Pöggeler et al.
Table. 16.1. Genes involved in fruiting-body development
Organisms Gene Gene product Defect of mutants Reference
Neurospora
crassa
asd-1 Rhamnogalacturonase No ascospores Nelson et al. (1997b)
ndk-1 Nucleoside diphosphate Light-dependent
Ogura et al. (2001)
kinase
positioning of perithecia
sod-1 Superoxid dismutase Light-dependent
Yoshida and
positioning of perithecia Hasunuma (2004)
nuo12.3, Subunit of respiratory No ascospores Fecke et al. (1994),
nuo20.8, chain NADH dehydrogenase
Duarte et al. (1998),
nuo30.4,
Almeida et al. (1999),
nuo78,
nuo51,
nuo24,
nuo2
Duarte and Videira (2000)
mfa-1 Hydrophobic peptide Male sterility, aberrant
Kim et al. (2002a)
pheromone
female sexual development
and ascospore production
pre-1
gna-1
GPRC, pheromone receptor
Gproteinαsubunit Female sterility
Female-sterile, no perithecia
Kim and Borkovich (2004)
Ivey et al. (1996),
gna-3 Gproteinαsubunit Smaller perithecia with no beaks,
Yang and Borkovich (1999)
Kays et al. (2000)
gnb-1
gng-1
Gproteinβsubunit Gproteinγsubunit reduced number of ascospores
Female-sterile, no perithecia
Female-sterile, no perithecia
Yang et al. (2002)
Krystofova and
Borkovich (2005)
krev-1 GTP/GDP-binding protein; No perithecia Ito et al. (1997)
cr-1
member of the ras superfamily
Adenylyl cyclase Delayed perithecia
Perkins et al. (1982),
and ascospore formation Ivey et al. (2002)
mak-2 MAPK, related
Female-sterile,
Pandey et al. (2004),
to S. cerevisiae Fus3p
and Kss1p
no protoperithecia
Li et al. (2005)
nrc-1 MAPKKK, similar Female-sterile,
Kothe and Free (1998)
to S. cerevisiae Ste11p no protoperithecia
nrc-2 Serine-threonine protein Female-sterile,
Kothe and Free (1998)
kinase
no protoperithecia
rgb-1 B regulatory subunit of the Female-sterile,
Yatzkan and Yarden (1999)
type 2A Ser/Thr phosphatase no prothoperithecia
ham-2 Putative transmembrane Female-sterile,
Xiang et al. (2002)
protein
no protoperithecia
eat-2 HighlysimilartoadomainFemale-sterile,
Randall and
present in the plasma no prothoperithecia
Metzenberg (1998)
cel-2
membrane ATPase
β subunit of fatty
Fewer peritecia, rare ascospores Goodrich-Tanrikulu
acid synthase
et al. (1999)
asm-1 Transcription factor with Female-sterile,
Aramayo et al. (1996)
APSES domain
no protoperithecia
vma-1 Subunit A of the V-ATPase Female-sterile,
no protoperithecia,
can not donate nuclei in a cross
Bowman et al. (2000)
cpc-2 WD-repeat protein required Female-sterile,
Müller et al. (1995)
to repress general amino
acid control, scaffold protein
no protoperithecia
rco-1 Multidomain protein that Female-sterile,
Yamashiro et al. (1996)
mediates transcriptional
repression
no protoperithecia
asd-4 GATA-type zinc finger
transcription factor
No asci, no ascospores Feng et al. (2000)
wc-1 GATA-like zinc finger No phototropism
Ballario et al. (1996),
transcription factor of perithecial beaks
Oda and Hasunuma (1997)