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DRS2012 Bangkok Proceedings Vol 4 - Design Research Society

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A Critique of <strong>Design</strong> Methods in Synthetic Biological <strong>Design</strong><br />

the definition of these units in its capacity to provide explanations to natural phenomena<br />

(Gánti 2007) (Rheinberger 2010).<br />

In design, challenging the units of a representation often prove to be more important than<br />

the designs themselves as the method of design can drive the products of design towards<br />

quite predictable outcomes which can immediately turn into design styles (Stiny 2008,<br />

Schumacher, 2010). Biological design not only provides a unique opportunity to rethink<br />

the units of the living and expand on how they can be chemically or biologically<br />

repurposed for different designs, but also introduces new logics of design that utilize rules<br />

and grammars of synthesis, flow, diffusion, and organization that can extend beyond the<br />

evolution-bound biological and component-based design paradigms.<br />

In today’s engineering, product design, graphic design, architecture, and research, we<br />

already witness a bottleneck of creative expression in the design of form and function<br />

through unitary methods. As we approach a new frontier in design, where synthetic<br />

artifacts will claim more everyday roles, it is becoming increasingly important to set more<br />

discursive research agendas that can shape the perception, use, and design of these<br />

new artifacts.<br />

References<br />

Alon, Uri. 2007. An introduction to systems biology: design principles of biological circuits. CRC Press.<br />

Antonelli, Paola. States of <strong>Design</strong> 07: Bio-design - <strong>Design</strong> - Domus. Domusweb.it.<br />

http://www.domusweb.it/en/design/states-of-design-07-bio-design-/.<br />

Cogdell, Christina. 2010. Eugenic <strong>Design</strong>: Streamlining America in the 1930s. University of Pennsylvania Press.<br />

Deplazes, Anna, and Markus Huppenbauer. 2009. “Synthetic organisms and living machines : Positioning the<br />

products of Synthetic Biology at the borderline between living and non-living matter.” Systems and Synthetic<br />

Biology 3 (1-4) (December): 55-63. doi:10.1007/s11693-009-9029-4.<br />

Endy, Drew. 2005. “Foundations for engineering biology.” Nature 438 (7067) (November 24): 449-453.<br />

doi:10.1038/nature04342.<br />

Gánti, Tibor. 2003. The principles of life. Oxford University Press, November 27.<br />

Gibson, Daniel G., Gwynedd A. Benders, Cynthia Andrews-Pfannkoch, Evgeniya A. Denisova, Holly Baden-<br />

Tillson, Jayshree Zaveri, Timothy B. Stockwell, et al. 2008. “Complete Chemical Synthesis, Assembly, and<br />

Cloning of a Mycoplasma genitalium Genome.” Science 319 (5867) (February 29): 1215 -1220.<br />

Jacob, François. 1974. The logic of living systems: a history of heredity. Allen Lane.<br />

Krohs, Ulrich, and Peter Kroes. 2009. Functions in biological and artificial worlds: comparative philosophical<br />

perspectives. MIT Press, March 31.<br />

Luisi, Pier Luigi, and Cristiano Chiarabelli. 2011. Chemical Synthetic Biology. John Wiley & Sons, May 31.<br />

Mead, Carver, and Lynn Conway. 1979. Introduction to VLSI Systems. Addison-Wesley Pub (Sd), December.<br />

Pearson, Helen. 2006. “Genetics: What is a gene?” Nature 441 (7092) (May 25): 398-401.<br />

doi:10.1038/441398a.<br />

Purnick, Priscilla E. M., and Ron Weiss. 2009. “The second wave of Synthetic Biology: from modules to<br />

systems.” Nat Rev Mol Cell Biol 10 (6) (June): 410-422. doi:10.1038/nrm2698.<br />

Rasmussen, Steen. 2009. Protocells: bridging nonliving and living matter. MIT Press.<br />

Rheinberger, Hans-Jörg. 1997. Toward a history of epistemic things: synthesizing proteins in the test tube.<br />

Stanford University Press.<br />

Rheinberger, Hans-Jorg, and Hans-Jörg Rheinberger. 2010. An Epistemology of the Concrete: Twentieth-<br />

Century Histories of Life. Duke University Press Books, September 6.<br />

Sia, Samuel K., et al. "An Integrated Approach to a Portable and Low-Cost Immunoassay for Resource-Poor<br />

Settings." Angewandte Chemie International Edition. 2004.<br />

Conference <strong>Proceedings</strong> 1851

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