6 MILLET ET AL.Downloaded By: [Mil<strong>le</strong>t, Xavier] At: 10:57 4 November 2009Figure 2. Estimated effect sizes (and 95% CIs) of priming scores between Alzheimer’s disease (AD) patients and elderly control groups.Note: Area of the squares is proportional to the study statistical weight in the overall effect size.Comparison of word-stem priming between ADpatients and elderly controls for each encodingconditionIn the third set of analyses, we were interested in comparingword-stem comp<strong>le</strong>tion priming performancesbetween AD patients and elderly controls within eachencoding condition. Several subsets of studies were consideredaccording to the encoding instructions providedto participants. Significant heterogeneity between thestudies was encountered for each analysis (Q values arereported Tab<strong>le</strong> 2). For each encoding condition, we estimatedthe effect size between priming performances of ADpatients and those of elderly controls groups (Tab<strong>le</strong> 2).Forest plots showing the effect sizes and 95% CIs foreach encoding condition are displayed in Figure 3.For the studies involving an encoding conditionrequiring participants to generate a word (F<strong>le</strong>ischmanet al., 1999; F<strong>le</strong>ischman et al., 1997; Grosse et al., 1990),the meta-analysis was conducted on a total of 131 ADpatients and 96 elderly controls and yielded a trivia<strong>le</strong>ffect size (–0.06, CI 95% [–0.51; 0.40]). Priming performanceswere not significantly different between thetwo groups.A sing<strong>le</strong> study involved an encoding condition requiringparticipants to make semantic judgments (BeauregardTABLE 2Effect sizes and 95% confidence intervals between AD and elderly participants’ primingperformances for each encoding conditionStudies(n)Poo<strong>le</strong>deffect sizes Q 95% CI p valueRead 7 −0.45 9.50 −0.75 −0.16
WORD-STEM COMPLETION PRIMING IN AD 7Downloaded By: [Mil<strong>le</strong>t, Xavier] At: 10:57 4 November 2009Figure 3. Estimated effect sizes (and 95% CIs) of priming scores between Alzheimer’s disease (AD) patients and elderly control groupsin each encoding condition. Note: Area of the squares is proportional to the study statistical weight in the overall effect size.et al., 2001, Experiment 2). The meta-analysis conductedon 11 AD patients and 12 elderly controls yielded a smal<strong>le</strong>ffect size (–0.32, CI 95% [–1.14; 0.50]). Priming performanceswere not significantly different between thetwo groups.A sing<strong>le</strong> study involved an encoding conditionconsisting in counting vowels (Car<strong>le</strong>simo et al., 1999,Experiment 1). The meta-analysis conducted on 15 ADpatients and 15 elderly controls yielded a small effect size(–0.38, CI 95% [–1.10; 0.34]). Priming performances werenot significantly different between the two groups.For the studies involving an encoding condition consistingin providing a definition of the target words(Burke et al., 1994, Car<strong>le</strong>simo et al., 1999, Experiment 1;McGeorge et al., 2002; Partridge et al., 1990), the metaanalysisconducted on a total of 66 AD patients and 66elderly controls yielded a moderate effect size (–0.75, CI95% [–1.52; 0.02]). Priming performances were notsignificantly different between the two groups.For the studies involving an encoding condition requiringparticipants to read the target words (Beauregard et al.,2001, Experiment 2; Downes et al., 1996, Experiment 3;F<strong>le</strong>ischman et al., 1999; F<strong>le</strong>ischman et al., 1997; F<strong>le</strong>ischmanet al., 2001; Koivisto et al., 1998; LaVoie &Faulkner, 2008), the meta-analysis conducted on a totalof 188 AD patients and 161 elderly controls yielded asmall effect size –0.45, CI 95% [–0.75; –0.16]). Primingperformances in the AD patients were significantly lowerthan those exhibited by the elderly controls.Finally, a meta-analysis was conducted for the studiesinvolving an encoding condition requiring participants torate likeability (Arroyo-Anllo et al., 2004; Burke et al.,1994; Car<strong>le</strong>simo, Fadda, Marfia, & Caltagirone, 1995;Car<strong>le</strong>simo et al., 1998, 1999, Experiment 2; Downes et al.,1996, Experiments 1 and 3; F<strong>le</strong>ischman et al., 1999; Pasquieret al., 2001; Perri, Car<strong>le</strong>simo, Serra, Caltagirone, & TheEarly Diagnosis Group of the Italian InterdisciplinaryNetwork on Alzheimer’s Disease, 2005; Salmon et al.,1988, Experiment 1). The meta-analysis conducted on atotal of 267 AD patients and 290 elderly controls yielded astrong effect size (–0.86, CI 95% [–1.17; –0.55]). Primingperformances in the AD participants were significantlylower than those presented by the elderly controls.Publication biasWe assessed publication bias with Egger’s regressionasymmetry test. The analysis indicated that a publicationbias affecting the results of the present meta-analysis isunlikely (p = .11).DISCUSSIONThe present meta-analysis was designed to investigateword-stem priming in AD and the potential influence ofprocesses operating during study phase on the performancesexhibited by the patients. The first result thatcomes out of this study shows that when the data acrossencoding instructions are combined, AD patients manifesta significant priming effect ref<strong>le</strong>cted by the strongeffect size (1.15, CI 95% [0.95; 1.35]) between comp<strong>le</strong>tionrates obtained with the studied items relative to theunstudied ones. However, despite this positive influenceof previously studied items on later comp<strong>le</strong>tion rates, themagnitude of priming in AD appears definitely lowerthan that evidenced by the control group (–0.60, CI 95%[–0.79; –0.40]). This result is consistent with prior metaanalyses(Meiran & Jelicic, 1995; Russo & Spinn<strong>le</strong>r,1994) concluding that word-stem comp<strong>le</strong>tion priming isimpaired in AD patients. Moreover, after considering differentsets of studies according to the <strong>le</strong>vel of processing
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Université Bordeaux 2 - Victor Seg
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ABSTRACTResidual cognitive abilitie
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visites sur site (souviens toi la S
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« Dans le parc du château, il y a
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Procedural memory in patients with
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625-632). London: Academic Press.La
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Patterson, K., Graham, N., & Hodges
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test: role of aging and divided att
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• Photographies des visages distr
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Epreuve de titresCe travail de thè