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ObservationtimeDrop-outrateOutcomeStudy qualityComments21 days 4% Median time to resolutionof otorrhea:Cip+Dexa: 4 daysAmox/Clav 7 daysp=0.0006Clinical cure:Cip+dexa84.6%Amox/Clav 58.5%p=0.01HighHigher rate ofadverse eventsin Amox/Clavgroup (29% vs13%)3 weeks 16%424 included in analysiswith positive culturefor bacteria, 357 wereculture positive andpresented at all scheduledvisitsClinical cure:Cip+Dexa: 92%Ofloxacin: 73%p=0.02MediumOnly childrenwith positivecultures wereincluded in theanalysis2 weeks 8.5%(all those with negativecultures were excludedin the efficacy analyses)Otorrhea resolved by day 8:Cip+Dexa: 84%Cip eye drops: 70%p

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