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Table 3.1.2.1 Long-term antibiotics for prophylaxisof recurrent acute otitis media.AuthorYearReferenceCountryStudydesignPatientpopulationInterventionControlKoivunen et al2004[59]FinlandRCTDoubleblindn=120Age: 10–24 monthsrAOM rate >3 episodes/6 months, mean numberof episodes at entry 6.031% had SOM at entrySulfisoxazole x 1 for6 months: n=60Placebo x 1 for 6 months:n=60Treatment time: 6 monthsRoark et al1995[198]USACasselbrant et al1992[56]USARCT n=158rAOM rate: 3 episodes/6 monthsRCT n=264Age: 7–35 monthsrAOM-rate:>3 episodes/6 months>4 episodes/12 monthsNo effusion at entryNo adenoidectomyAmoxicillin: n=99Placebo: n=59Treatment time: 45 daysAmoxicillin 20 mg/kg/day x 1: n=90Placebo: n=88VT: n=86Treatment time: 2 yearsListon et al1983[60]USARCT,cross overn=43rAOM rate: ≥3 episodes/6 monthsSulfisoxazole: n=22Placebo: n=21Treatment time: 3 monthsPrincipi et al1989[61]ItalyRCT n=100rAOM rate: 3 episodes/6 monthsAmoxicillin orco-trimoxazole x 1: n=66Placebo: n=30Treatment time: 6 months88Rörbehandling vid inflammation i mellanörat