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InterventionControlFollow-uptimeDrop-outrateOutcomeStudy qualityCommentsAHS – spray x 1:n=22Controls: n=21Treatment time:6 monthsEnd oftreatmentAHS: 18%Control: 5%Episodes of AOM:AHS: 44%Controls: 40%nsMediumPcV profylactic,selfmedication atURTI: n=30Placebo at URTI:n=4012 months 22% Number of AOMepisodes per childper year:PcV: 1.4Placebo: 1.5nsMediumIgG (gammaglobulin)spray intranasallyx 3: n=17Placebo: n=166 months 34% Number of AOMepisodes during6 months:IgG: 31Control: 31LowPcV profylactic,selfmedicationat episode of URTI:n=35Placebo: n=416 months 5%9% failuresof follow-upNumber of episodesAOM per child:PcV: 0.5Placebo: 1.0p

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