Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
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M .@onim @tate. aceroniuile and l'ielhyle<strong>in</strong>e (2:2:l:0.04 v/v/v). dete.don l<strong>in</strong>it ws<br />
ls tha E ngbln lo. atl @mpounds , *irb ctrrciots <strong>of</strong> wi.rion lN thD 19o (for <strong>in</strong>bed<br />
i ra.day) ovd lh€ co.c.nrration rtus€ <strong>of</strong> I-IOOO ngmln, MBtaf.1216l develop.d ed<br />
vrlidared HPLC ncthod for th. simultaFu aDtysis <strong>of</strong> mlodipi@ ed v.lsrna <strong>in</strong> mpls<br />
for liv€r p€rfisiod s1udi6. This Eerhod ws foud to bc li.@ with<strong>in</strong> ih. rug! <strong>of</strong>0,05 !o 60<br />
!snI--I, LOD ed LOQ v.lu6 \re 0.02 snd o.o5 llgnrr for bolh lDlodipire ed v.isdt n.<br />
VoE and kdav [251 daclop€d R.P-H]LC nethod for s<strong>in</strong>ultlmu d.lediution <strong>of</strong><br />
bispelol fiddaL dd ulodip<strong>in</strong>e bBylale <strong>in</strong> i.bleis, L<strong>in</strong>@ity wa e$ablished <strong>in</strong> lhe arse<br />
<strong>of</strong> 8-31 ,!8DL-r. Md l@very w6 9.1% ed 98-6yo for bisoFotol fr||]qt .!d<br />
drnodip<strong>in</strong>e b€sylsL, r€sperively. chaldh6i ,/ at, I25El desib.d e RP.HPLC method foi<br />
thc s<strong>in</strong>ul|InoE .stimdon <strong>of</strong> aroMqat<strong>in</strong> ed dlodipift fibh th€n cmbiInios dn8<br />
prcdDct. A sability <strong>in</strong>dicadng RP-HPLC me<strong>tn</strong>od h6 bcn da.loped ard s$lequatly<br />
vdid.t d for simultllHB .si<strong>in</strong>ation <strong>of</strong> mlodipim pEnt s lnlodip<strong>in</strong> b6ylar. ed<br />
h..mpril ny&ochlorid€ frcn fien @nb<strong>in</strong>arion Dtuducr. The d.sqib.d n thod ws Un€e<br />
ovc . ran8. <strong>of</strong> G l4 pgnLi for sblo
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