Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
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6 C.tirizib. ritb r imrl.d.lt<br />
I S<strong>in</strong>tLa@ts detem<strong>in</strong>atiok oIcefthift l, preleace <strong>of</strong>antltularlah<br />
In om <strong>of</strong> thc an|di6 a ce <strong>of</strong> d.l.y.d Fss@ urtiwi. w p@l.d <strong>in</strong> whjch<br />
,dihistuiG g+ rct efedre. tlo**r, drrbddid E found 10 prldue positiv€<br />
imF.i [270]. In eolhd .& or aut uiidia dd algio€dqE onl etihisrabiB showed<br />
no dier <strong>of</strong> sydploos. rbwv.r, 06l chlobqu<strong>in</strong>e shoqed ! .lrmatic <strong>in</strong>povtuot <strong>in</strong><br />
patie condition t2?ll. ln solr uniceio dimalrial tptrn€ M .fiecdve [2?2]. nE<br />
ddotdtids, c oroqu<strong>in</strong>*, hydnxychlooqu<strong>in</strong>€. ed quim.nn€ e usd prihdily lot<br />
maldia but th.y cd b. b.n ficial for c!ran6$ lupu dtlhmatoss (LE), pollmoQhoB<br />
liclt duptioo, el& uni@i! &d Frph"ia cur8@ I'd. t273l. siftc etmldi.is e efely<br />
coado<strong>in</strong>islcEd dnSs <strong>in</strong> pEpM <strong>of</strong> er<strong>in</strong>2irc .d haw shoM . poitivc cull <strong>in</strong> dr<br />
l@rndt <strong>of</strong> liliwi. hene a nov€l &P-HPLC F.thod m develop€d [o simultaMuly<br />
q@dry cdni<strong>tn</strong> <strong>in</strong> presm <strong>of</strong> ml<strong>in</strong>aldials. Nu€rcN RP-HPLC h.thods have b€a<br />
Fported for the d€tem<strong>in</strong>adon <strong>of</strong> dtiDalaials. B.ll a ar, [2?4] dev€lop.rl HPLC melhod for<br />
th€ qu.ndrsdr! detcrnilalio! <strong>of</strong> @mon etimaldials, they q@tificd stdfado<strong>in</strong>e,<br />
pyrimlb@i@, chlorcqui!.c, dodirqui& &d .16.:thyldodiaquift lion wbol€ blo.d.<br />
Cdibdion crc wcc l<strong>in</strong>@ (rL0-9t <strong>in</strong> dE MS6 5 l0O llSnl-], 5O-IOOO, 150 1500,<br />
100 1000 and 100-1000 ngml r for sutfadorirc, p}T<strong>in</strong>dhtuift, chlobquiE, dodiaquift<br />
ed desihylmodiaquire. Esp€.tively. ,&. dr 4t, [2?5] de$ib.d mcilFd for ihe<br />
d€t mi@lion <strong>of</strong> pyrimethd<strong>in</strong>e, sulfadie<strong>in</strong>c sd its melaboliL N-acdyl-lllf.diuiE <strong>in</strong><br />
plama mpl.! fom rconals, s@ple tftp@tion wa bded on proreio pdipitadon. The<br />
dalysis s perf<strong>of</strong>r.d usila HPLC with UV md ns spet onmic dcEcrion.<br />
Ii tbe plffir *ort, ! w merbod B<br />
dcvelopcd .rd $lidn
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