Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

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dcficimy @ b€ b€st d€teted tbougl a pos'tiv. 6IoM to $ppl.henrllion rridr. Zirc supplcm.ntltion h6 ben shom b bav€ a p6iriv..f€.t on tne incidae oadieba ord pnemonia md nigh lead lo a da@e in thc incideM of mal&io. Zinc hs de prolen lo d€cr€6e lh. duradon ofdiuhea by 15% [1591. ft€ impondce ofzinc for huna hqlin wa fist docmentcd in 1963. Duing ttr€ p6l 25 yds, denci€ey of zinc in hhm due 10 nutritiomlfrctos dd Fvenl dist* sl!l$ h6 now be@ !@cniz!d. Zinc is rcquiFd for ndy biologicsl turctioN imlnding DNA synthcais, kll divisiotr ed gde dpcssion. ll is r€quircd for th. activny of tIEy.My@s in biologic.l sysrem. R@ studics indicaE th4 zinc is nad.d for @ll-n dial€d ilmuity. U601, d.ily EquiEne is l0lo l5 h& l0lo40 % of the di.lary zinc is abe.bed ftom lhc arDll i.Gsti@, the absQtion appea to be Mi.r.d wirh nuiilionrl $ars [16l]. Absolprion of ntr ba b@ d€cEa.d wilh rhe fomalioD of insoluble mmpldB wilh phrlli. (@rcrlt, calciu, villlnin D, prctcin dd fib.r. hc@ed copper inlaks m also suppFss zi.c ab$rplion by @npelition fot albunio bindins sites 1162l. It h excEled in the f.ces wirh only tr@s apFding in the uin. sinca th€ kidrcys h.v€ liul€ or no rcle in rcsulatins the cont nt ofzi@ in lhe body 0631. l0 CadniM is ! hana meral with a high roxicity, it is loxic ar v.ry lo* qposw lev.ls ed has eulc ed chrcnic clfdrs od halll dd dvimmo. CadniM is .ol d€gmdabl. in tutft dd will ths, on@ lelq$d lo rhe envirmen|, stay in cionstion. Nw elcss add lo $e alaady .xistine d.posis of @dsim in rhc e.vircm.ni. Csdmim tud codniu conpobds m, @np@d !o other h€avy b.lals, relatilely MLr sluble. They N th€Efore also noE Dobile in €.s. soil, senerolly more bioavailabl. &d t€nd lo bi@mulat€. Chonic @dnim exposw produc.s a wi.l€ vdiely of &u. &d ctronic €fsrs in hdm. cadniw umulat.s in tlE humm body dd €sFcially in rhc tidn ts [164]. Cadrbim sulphid. ed cidniM sdd.tc had betr used for rh€ r,lsl,ndt of stin @ndition &d cy. iritclion, Gpetilcly 1165l A suficior @@E tid (200 l1r/s) dabasd ilE Lidney cell, Gultiry in preximal ruhle i.juty and Foteinuia U66l- ln rh. GI te! rhe abGotplon of cldniE is poo', studies in $e laboFtory einals indiqLd tht enenr of absorydon lo b€ only l.t% [167] md limit d sludies in M indlcated d valu. of 6bout 5%. Appoximolely 50vo of$e toral body bu.den, aner dhtdbution is foud in lhe liver dd kidneys. Livei dd kidney cont ins n.tallolhion€n, which is ind@ible by .xposw $ cadsiM [68]. t0
tdd hody kd.a d.r diliihdm ir tutld h dr liE .!d tidE r Liw rd kidDy old E t![oltio@4 *hici i, irdu.iblc by deore ro cldoiun [r6t]. E Inn.m.d.Ldq ..tirirt tfidei.. d€* .!d q,totiD Fo.tud!6 by oa c.{t .rd b..o0tit. & rho!8h !o t ilslv.d h t r.dosrori. of.lt .sic dir.r... Ir t8 b€.n ra0ord ttd dlagic didg e i!tdt!.d by corylicrrd ibfunc Espord .ad ory iMlve itrtl|noltqy o.dhr.6 &ch u HrlrDir. rd.nli&oic.cid uarloli4a crbtin r.!d o.sy dift.ed ccn typ6 iocldi.g T cd|!' ur ocr4 brrorhr., ialtqbiL\ |tryqt gd a. trral. T cdtr e i@h4d i! lh. ''Fr'.i@ .ad ngl!!l[ of .lld8i. intrdn|li@ .!d .Ey phy rotc i. tt ctrcoicity of6. dir..$ tltrt r.gdlde tt iDEM .€+@e ro for.ig! t i!€o! od p|nioipCte i! it 'Dridr{@ of Fipt...|.!d o..Ld loLr|e [r?1]. A etd.dhl ho
Page 1 and 2: DRUG.DRUG INTERACTION STUDIES OF CE
Page 3 and 4: llfris tfr-tis is &atcf to rtJ N6rr
Page 5 and 6: S.No Dadl3 B c D E B c D E Hisory H
Page 7 and 8: E F CairiziE witb NSA.ID'3 Sinuli'e
Page 9 and 10: l0 |l l2 RESEARCII PUBLICATIONS ANT
Page 11 and 12: ABERf,VIATIONS Alnl An odipine PMA
Page 13 and 14: d ephthyldin . Th. rca.tion mh&bm f
Page 15 and 16: INTRODUCTION
Page 17 and 18: €valutcd. The nosl aDnug smup is
Page 19 and 20: wilh l@g le*iDg .ctivily. h I ob*o
Page 21 and 22: sllbiliad by inta holecurd hydrcgd
Page 23 and 24: iii High pre$we liquid chtohatogaph
Page 25 and 26: kela.@n@le withoul ihc incEbed nlk
Page 27 and 28: C Int nctilgdrug! Cetinzine is wide
Page 29 and 30: Resfuh on 4{uinolon.-3.carboxyhr€
Page 31 and 32: 3 Notst@idd .ttiJnfunmto,f dr.tt (N
Page 33 and 34: dslhma swh s coughinS, whezing, dd
Page 35 and 36: Hist.oc./melabolic s}t'dmne, which
Page 37 and 38: mirlende. rh. sErion of homones ed
Page 39: e$enrid fuciion ol cob.h is rs a co
Page 43 and 44: the h@d imw sysid pDi€ct lion dip
Page 45 and 46: u CwrhaealdttutirB Whia Dlood ard e
Page 47 and 48: Raw @&ituls a.d wft of Dtmr.uticd p
Page 49 and 50: AllD( 500 MHz spetron i.r sing IMS
Page 51 and 52: T.bl.2l LMit rdgd of@lra ob.yirls B
Page 53 and 54: solutiors. Con@.nadon tug€3 of al
Page 55 and 56: 3 Dmg- dru! i .ncriob srndi6 The D
Page 57 and 58: la* dd HBSS+ *s !dd.d to @h wll to
Page 59 and 60: RESULTS AND DISCUSSION The possibil
Page 61 and 62: s€@ we obs.led to b. 0.04 l!gn[ '
Page 63 and 64: povatul My of optinizing sel*dvny \
Page 65 and 66: m. xrcjD ., d. t{31 dd€lop.d d R!
Page 67 and 68: Ruggedrs ol ihc medod @ hld.!.d by
Page 69 and 70: Hce, b = lldr logth of $e ell ( I c
Page 71 and 72: nin'mM detectable linit of 5 lenl,
Page 73 and 74: The develoted nelhod M lppli.d tor
Page 75 and 76: Irr &nltri.al nsim for feotidirc .t
Page 77 and 78: tbh aS9 Ituftti@ r.s,Ls otethxiE wi
Page 79 and 80: et dt. [22E] q@rifi.d rhe sinvlsrlr
Page 81 and 82: Intudide pr*iriN of the Ntho.l % RS
Page 83 and 84: tbn ct .[dtttEadtu r=ll3!7i+0.0017
Page 85 and 86: Tr! Mid risr.l ohriBt ftr l[. Fw.dr
Page 87 and 88: l :l &rF1(,: Chudo'u.of iGdon .r Ct
Page 89 and 90: 3 C.dddr. rttt qrbolon6 I Shrtt@Bd.
Page 91 and 92:
Rerendon line obw.rl for ouinoton.s
Page 93 and 94:
LaLt al t*tdhl nattqedtur dh lo@t6
Page 95 and 96:
ft. r* ofofotuin .t pH I w fold ro
Page 97 and 98:
Rcg$sion sbdnics re sboh in tablc 3
Page 99 and 100:
T1E r'- of 3pd0oeir at pH I w'16I,
Page 101 and 102:
M .@onim @tate. aceroniuile and l'i
Page 103 and 104:
ihe ld.b of co@manon o. difrer d.F.
Page 105 and 106:
.5t lt9 Itur@tt@ wltt ofqd^nN db tn
Page 107 and 108:
.pfstd ttdiei3 ol c.tizitu dd z'tod
Page 109 and 110:
ft. n€thod for rh€ dcimination
Page 111 and 112:
mon dtd. pra*tu oftlz nhd %RSD 0.16
Page 113 and 114:
Epsilaau c wiw t'ft^ 15100 t29\7 t6
Page 115 and 116:
Ite ini.@rion reeultr of nubiprof
Page 117 and 118:
Th. % availability of ednzie ra4.d
Page 119 and 120:
* i t I o! I ',.! i; s is P E 3 I q
Page 121 and 122:
sym€F of p€ali. The reteition t
Page 123 and 124:
R.snt@ lotiurs ol.attN dA pnn4tmme
Page 125 and 126:
guinfenesir dd hont€lntal weE nos
Page 127 and 128:
IlF rhtive $andard &virtion of th
Page 129 and 130:
It beraato., e@.s dedtutu vih qd$tl
Page 131 and 132:
(ztxi@ twiiiu .lr.tiniw ad Dhpnv:|.
Page 133 and 134:
Lalence [29?] developed s HPLC tech
Page 135 and 136:
nbi..r.d to l! r!.llrir i! F@ (r.bt
Page 137 and 138:
Trbl.3.ll2 HPLC HPLC HPI' Hptc 97.t
Page 139 and 140:
I! th. deib.d pc.d!n, sp{rtio of il
Page 141 and 142:
23 m t0 l5 5 t01., 97.58 lfi 55 9t.
Page 143 and 144:
fi. l4itu of gliquido* d pH 9 a obs
Page 145 and 146:
inding. Cctirizire sinply dbpl.c.d
Page 147 and 148:
i t s .! € ! a 3 .E E E E E F g E
Page 149 and 150:
The !R spccta ol nubiprofd showed c
Page 151 and 152:
The deshi€ldin! efl*t ws .x.ned i
Page 153 and 154:
F Synrb6ir of d..lr.tivs ol.dirlrim
Page 155 and 156:
M6iqn dat updQn47U 'y1 .^"-"-r" * \
Page 157 and 158:
7,21-7.7 ppm, Pre1on for th€ CII,
Page 159 and 160:
k meh Fonin !t at 3145.9? di , dipb
Page 161 and 162:
Emrs ninnnbdiN .elalatiM oldtMtvt B
Page 163 and 164:
€stosiblc for prcd@i!8 sup@xidc a
Page 165 and 166:
T.U.3Jl *n6tttc of eniziu atd iE t
Page 167 and 168:
.50 u, / i[ a r2s l{/ irl o3.12|,gr
Page 169 and 170:
i o lne @F sh&te of eririziE with d
Page 171 and 172:
l0 ll t2 l3 I5 l6 REFERDNCES John C
Page 173 and 174:
l2 33. 34 l5 36 37 38 t9 4l 45 Bewi
Page 175 and 176:
67 63 69 70 7l 72 11 14 15 16 77 78
Page 177 and 178:
03 H.ltltm JO, Linbid LE ald CilrM
Page 179 and 180:
tl9 Anyn€ Ms ed Sdr@ N (19E0) C.l
Page 181 and 182:
175 t16 t77 t78 t19 180 t8l 182 l8l
Page 183 and 184:
211. wmg D, Clcoenr P ed Smirz J 09
Page 185 and 186:
240 Ters@ H, Aliomi M ard T.tmi y (
Page 187 and 188:
tumour dcs cel.coxib ohace the dti,
Page 189 and 190:
300 301 302 Shilde vM. d6ai BS .rd
Page 191 and 192:
330 Baltaba UA, MaklMov Ac, ZdkiFv
Page 193 and 194:
cdi;rrcdihyddhroid. (Ps)-2-12-l4l(4
Page 195 and 196:
uor fron I b 9, ud rd lk Fq dutb: c
Page 197 and 198:
l ni[ rh.n annilused fdr 10 nii n 1
Page 199 and 200:
i.!r.IFliEdMJennd'd,4 JLD$ ftt ' 'o
Page 201 and 202:
n.'tr'ddn.nq!t4-d.F ut rr!-orre@dma
Page 203 and 204:
wdEldaNPlh.iffu&!nd@ry Modv.., our
Page 206 and 207:
vi4l.slocl?@'fud!@e@dd'd,(D''ih)'dy
Page 208 and 209:
I 56,|J'ciri's.c'.'|',vo|I.No'4.!04
Page 210 and 211:
Y* ser r.cl..,f.*,r, v"r. ro uIr.,
Page 212 and 213:
Simultrnoous Dctermination of Cctir
Page 214 and 215:
P49 An RP-HPIC m.lhod tor tte slnul
Page 216 and 217:
Ilt 3'7i-- L:; -_I i' a \l
Page 218 and 219:
Intenational Clenistry Conference R
Page 220 and 221:
,/ :l i{ AB,S RACTS 7'I INTERIATIoN
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Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

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