Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
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P49 An RP-HPIC m.lhod tor tte slnullar.ous d.temlnauo. ol celi.L<strong>in</strong>e ln<br />
pEsence ol qulnolon$ <strong>in</strong> bulk maletul, phamaceulidl lonnulations and human<br />
U!!:S!!!$3!, NaJm. sultana and M. saeld A'.yno<br />
Rese.rch Inslitule ot Plamaceuti*l Scienca, F cully <strong>of</strong> Pham.cy lt tab 9,<br />
0eparlmenl olChemiBlry UnlveFity ol Xaracht, Ka.achi.75270, Pakistan<br />
An acc"rale. sens lNe and easr Ine mlsum.T RP.FPLC reh;d to'rhe estmahol ol<br />
c€Inz<strong>in</strong>e <strong>in</strong> lhe presence ot qu<strong>in</strong>otones i.e cip<strong>of</strong>loxac<strong>in</strong> on<strong>of</strong>lonc<strong>in</strong>, spamoxac<strong>in</strong>,<br />
norfiorec<strong>in</strong>, levolloxac<strong>in</strong> and olloxac n was devetoted and vatidated <strong>in</strong> active, dosage<br />
tomurations .nd <strong>in</strong> h! man seah Ceridn n. €tuled tom purcspher Srar, C 1 8 (5 nm. 250<br />
t 4 6 nm) column al room temperature us ng mob te phase <strong>of</strong> melhanot: scelon ldte:<br />
waier (50:20:30 vA/) at a fld .ale <strong>of</strong> lml n<strong>in</strong>urei $hite W deteclion l!?s periomed al<br />
?25 nm. The .elention lime <strong>of</strong> celiiz<strong>in</strong>e was tound Io be 4.00n<strong>in</strong> and that ot ou<strong>in</strong>otones<br />
wes 2 5rri The LOO and LOO vatues ro, @, ?r @e tound ro be OOI and O 0l<br />
mqnnLi. The method ,as va rdared tor accuracy, sensitiul, pecision, spe.jktry and<br />
ruggedness. Calibralion cuft€s were tound to be l<strong>tn</strong>eff wilh<strong>in</strong> the Enge ? 5-50 mgmriL.<br />
, Mlh regressjon coeficient t2) O 999 The esrabtished H pLC method sas tou; to b€<br />
Eo'd ac.urate a.d seled ve be(else or 'rs se-5nv(yat Rpbduc,bilt Moreo/er, rhe<br />
D.esenl rethod was found ro be etiecl,vF tor rhe,aDeulc olrooscs
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