Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
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Tl@foe, a 3<strong>in</strong>ple @u.& od p@ie HPLC<br />
mlhod for situlllM6 delgbiEtion <strong>of</strong> rh.s<br />
drues ws dt loFd. 115 rhc* drugs &e<br />
availabl€ <strong>in</strong> coDb<strong>in</strong>alion ed e nostly @<br />
dmiNler.d $ a medod wb Foposd lor $.<br />
simdran@s deLmimtion <strong>of</strong> de drugs <strong>in</strong> <strong>Fw</strong><br />
materials, dosg. fom'nalionr ed <strong>in</strong> b@4<br />
elm us<strong>in</strong>S ibupr<strong>of</strong>en as e i eml staidald.<br />
Ihe d€velop€d ne6od w6 foud lo b€ wid.ly<br />
lppli€ble trd @dd be usd for U.r@utic Dd cl<strong>in</strong>icd purp.*r.<br />
ChM.rogm <strong>of</strong> dnas, r=<br />
Fsuoifd.s<strong>in</strong>, c=et<strong>in</strong>zirc,<br />
Ssi6 <strong>of</strong> exlqimmis w@ .ondu€i€d lo .srablish d. oFimM hlE <strong>of</strong> rh. &allric.l<br />
vdiabl6- 'Ir,e pam.LB optimizd imludcd mobile pl@ vdietions dd $me physical<br />
v&iau6, irclud<strong>in</strong>s th€ fiow 8L &d the s!1. lolue adjuun€rt oI pH. MoE over. ir<br />
B obscd lhar lolg th. conccnF.rior <strong>of</strong> w{€r ln. shonq Uc rererlio! rim. <strong>of</strong> rl de<br />
dDgs esuh<strong>in</strong>g <strong>in</strong> overlapp<strong>in</strong>g <strong>of</strong> peaks. hcr€se <strong>in</strong> oMnlration ot wate. upro l? triL,<br />
Gsulted <strong>in</strong> fal.r 6d b€tLr s.p@lion <strong>of</strong> p€.ks <strong>of</strong> atl lhe drugs. However, DoF <strong>in</strong>cMe <strong>in</strong><br />
orenFatior ol *arq 6uhd <strong>in</strong> very lorg fr.nlon dne for no el&6t. HeMfonl\ th.<br />
opt<strong>in</strong>m @hFsilion <strong>of</strong>d. nobile pb& w.chided ir a otio <strong>of</strong> 17 vateij 4 ebdrrite<br />
ed 75 neteol fo! shdp ed well Fsolv.d p.ats. Acard<strong>in</strong>8ly, the flow or. q6 ale<br />
adjuled e thai lor lbe drugs it w6 sr al L I hlniri' dd for monteluk6l ir w6 et ar L5<br />
ml-m<strong>in</strong>'r. ThG oPliru @nposition <strong>of</strong>de nobilc ph* @sisr.d <strong>of</strong>metheol: *eronirriL:<br />
sre (79:4:17) drd s pE 2.7, sdjusred by orrlophcphdic &id for mpid dd wlfEelv€d<br />
peets <strong>of</strong>all lhe drugs, Ac@rd<strong>in</strong>gly,lhe gradie nowmle system wd utiliad fornonitor<strong>in</strong>g<br />
<strong>of</strong> chMulogms by <strong>in</strong>todrc<strong>in</strong>r ptugllm<strong>in</strong>8 <strong>in</strong> sftwe. So lh. flow Ele wd adjuled <strong>in</strong><br />
srch . uy rhat for th@ drugs i... cdniz<strong>in</strong> , phayl.phni!. a.d erdnfdEsio n *s l l<br />
mlmir'r dd for monteluld it *6 1.5 Dln<strong>in</strong>r. The !€r61ion (mes <strong>of</strong> rb. druss w@<br />
foud lo bd 2.5 D<strong>in</strong>utes for phenyl€phldne, I m<strong>in</strong>ules for gui.f€n€s<strong>in</strong>, 3.6 miNtes fo!<br />
c€lirizi@, l0 m<strong>in</strong>ulB for @orclulsl dd ibup<strong>of</strong>o (<strong>in</strong>i.mal stadd&d) €lur<strong>in</strong>g out al 7.2<br />
h<strong>in</strong>ut s. Thc Uv spetE <strong>of</strong>ildividud drugs vw @ord.d ald @mFld <strong>in</strong> lhe wv.L.sth<br />
tuse non 200 ro 400 m. Th. choice lo w isb€stic Fid sa ar 230 M B .onsidd€d<br />
satisfacbry, p€milt<strong>in</strong>g the dekcrion <strong>of</strong> all dogs wirh adequre eosiliviry.<br />
ll5
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