Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

Iir'4ne.Iitte p4bid oJth. h.tkd
50 0|l 0.78
y.RSD %RSD
25 0.15 0.26 0.01
t2.5 25 0.05
o,072 0.75 0.08] IJ6
2.5 0.92
0.12 ) 0.61
t5 0.21 1.25 0.032
fte av€Es. v.lws of thc ag€d $lution 6poB6 (!eal d6) sed obseFed ro be asE d
wnh tne Alsh $turid sFls, within i2%. Tlle 7o rccoEns of tue, h pr6e@ of
s@ (bble 3,I l0) reveal.d the applicabiliry of |nelnod for rhemFrric &d clinicd pu+osg
ll tn ranio, of c.ftlzire vith @timl@iats
t2.5
to2_34 t01.37 95_1a
50 25 2
I00.ll
t0115 t0t.u r00.85
P-8ly@prctci, honologw I (?Bhl), noddaL s@irivity io a tuge of eiiftat&iat
@npouds. In th€ sc atudy, mdloquin ws shoM ro be . Fi.nr irhibftc of p-
glycoprobin tespon acdvity, incrcsing the sositivity of drus{esistdftmoi c.ll li@s to
cfotonc agdts [276]. Mc0oquift hlve both pFiosty b.e! sbou ro bird diFrty to p-
glycopret i4 alrhowh it des e with rhigha.6nity rh{ vP I2?4. TtF e.tsi! D€ruit 's
P-glycopDbin hobolog!., iDllMe d. sitiviry of malqia p@ircs to a div* tuge ol
&tiDaldiai druss bul lh. Mhetum by which n do6 e hs @i!cd obs@ [2?s].
Mdim of pyrihethmic dt aI pH \N* obedql !r 272 {rd 223 m. And .gplying 661
d.dv.tiw techniq@ th. i&lttical wvelagth Ft{red for dI pH t.v.ls \r@ obee€d ro be
.l 240,53 m for cdnizbc sd 224,84 M fd pyribelldii*.
|ll