Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
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Th! .bsrbuce mdim <strong>of</strong> ciociidire al &idic pH i... I &d 4 \|@ foud 10 be 218 M<br />
whft 4,.r pH 7.4 n 6 217 ed ar pH<br />
9, 216 m. Simulk@6 equatio! B<br />
.lplied fo. lhe deremiMtion <strong>of</strong><br />
ikmrd@dtu M^<br />
c.dridr <strong>in</strong> pes.tB <strong>of</strong> c<strong>in</strong>didiE,<br />
Th. .Filon vatB <strong>of</strong> llc drugs d th.ir<br />
10393.31<br />
tfi42.95<br />
186t t29<br />
E F.tiE cf@ and on th€<br />
<strong>in</strong>t et<strong>in</strong>g drugs Efelt@s ar v&ioq<br />
t6350 10371.91<br />
16350 r0t68 l4l5l.05<br />
pH lcv€h (i.ble 1.34) wft calcdsled dd !i.d for cslculgr<strong>in</strong>s the o/dvailabilily <strong>of</strong> dsss aftei<br />
thc i, lito <strong>in</strong>teradions. The % e@very <strong>of</strong> cdiriz<strong>in</strong> ed cimetid<strong>in</strong>e at all pH leveh mg€d<br />
bels.a 97-l04yo, This itrdi€aled th.r bo$ the &usr @ available rnd oone <strong>in</strong>rdfered wilb<br />
TrbLlJs<br />
IM.M rceib <strong>of</strong> etiitirc vth e ielAiw N Uy tpectophuowty ed<br />
HPLC<br />
pHl<br />
HPLC HPL' HPI-C HPI-c<br />
t<strong>tn</strong>27 100.t2 100,45 98,/tl _u lmi6<br />
l5 99.52 l0o,4J loo.t3 96.f2 98.54 t@?8 r0o.r2<br />
99.57 98.45 100.74 91.25 94.t2 t0t.14<br />
97.25 t0l.6l 97.33<br />
t0056 r0082 100.31<br />
99.t4 101.98 93.12<br />
l0t.2l 99.12 100.46<br />
I05 100.87 102.t4 99.6J 10071<br />
t20 100 t.] l00,ll l0l.ll t00.81 98.9 t01.46 I01.39 100.39<br />
105<br />
100.24 r04.l8 91.12<br />
t0l.t2 91.07 98.78 101.33<br />
t00.70 93.33<br />
98.32 r00.62 t02.45 9431 l0r ll<br />
94.41 99_t7 t00tl t01.65 10058 t00.23<br />
94.55 l0o.J4 9.t6 100.9 t@?8 101.34<br />
l0o.7l tot.62 10t.37 tmiT<br />
t20 t01.62 r00.J2 Im.03 I0t.39<br />
62
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