Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

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OP4IMIZ4TION OF QU NTITATIV!] ANALYSIS oT
CEI'IRJZINE USING MULTIVARTATE SPECIR^L
CALIBDITTONS IN BULK DRUG AND DOSAGE
TORMUL TIONS
N.jmnsuirano , M, Saed Aiay.e, and Hin! Shamshad'
Itrrcmch lnslitute of Phameeuljcrt Scicnc.s, Fncllry ot ph nrcy,
UilvcNity ol Kdrochi. K,rachi.7527O. prkhlan.
Dcplnmcnt ofChcmlsrry, Univcail! ot Xtlch , Kuraohr.75270, prtrr|i0j
A !implc muhvsare sp€crmt cahbr on Incrt,oJ t4r rne quJnrnr,,\(
rnrlysj! ol ccuhz'nc wrs ,leyctopcJ ,t hJr bccn loDpaEJ wnh rh.
llNicll ull'rvnt.r sp.dmphoromerric ftrhoJs tor rhe 6umalor ul
@dnnm.Thc n.thod was d€vctop€! in butf.^ of sjmutarcd sasrncju,cc
dd rinuh@d blood pH. Th. I'n* Egrssion cqurlon wJs uscd d ',vc
dfl.rcnr wJv.i.n8rhs. To lrtidlc 'tns n.rhoJ. inJbnc,,t prtumere s
luci 6 siccrrvr). 4-Jii!) MJ pr.rkiun ho\e beer e{rbhJco lrl
djlfcrcnt br.nG of tobleb and have b.cD .yatoitcd datsricany ro r$e$
lh. eplic!rion of rhe nrrhod. This ncthod js rupid,c$y, rnexpensive dxl
a powcdui t@l wnh very sinpie ndrhcmuricut ;onb ; ror sy(ems. Thc
mrhod hos bem jourd ro hJ\e ,,t\.ntJ8c tor ,,mp,r.r.). j..ti,,r.).
rnririvtry l0 56,-B), rrpndu! 'b'hry,n-lO, !nd rcdfu, tor E.r3 L\cL: \
rn .rcnrlc to rhe crisring ,nermnhnromrnc mcrtroJs ro, rtc rrrtr,.
aialysis ot ti. drg ns ph@@dcat tomutarjons and for cknical
dudi6. Euivalcrce uudie we4 dso pcrfomcd ror difaeEm btunds ol
cdnizinc rvail$lc in Pnkishn