Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

c$!6r.rin.i pH l. 4, ?.4 md 9 \r@ 51 23t.33, 210.81, 230.95, 230.E6 M, Esp41i!ely.
Tb. i,-rrto irctution Bdls of eririui* Mth Mwlsraiin r all pH d*igmred thd
atniziE did @l intcrf@ with oslBl.rin ,r rcidic or bsic pH. Thc 96!sil.biuli6 of
@tniziE at .lf buff.Ed nedims v@ foud ro tE i^ the tugE of 9.60-IM.WA
(detemioed by Uv speftpboton t r) ald 95.60-101.22% Oy HPLC).
R.wih tu1aict of c.tlzire @'d rctwMin
pH 1.0
srnB olati.iziN ,ith rdue.lcE d W r
0.gvn
HPIC HPIC HPLC
10068 r00.4t 9.8r 93.35 r00.48 t00.0t
94.24 99..10 lot 0 96.82 98.26
l0 95.21 98.?l 1007:
99.48 100.69 9t,24 100.22
99 6l 101.32 101.61 r0r.85 97..:.1 10.1.57 99.69
15 102.69 101.62 95.61 99.12 I01.23 l0l.3l
90 97.EE 101.87 I01.69 97.0E I0o.l2 101.87
105 t02.t5 94.2\ 93_7.] 98.2' 102_70 100.85 t0o.0i
r20 r00.6l 102.1t 104.9
94.62 9922 t01.22 tm.7l 99.29
t5 97.28 99.21 t01.29 93.t'
l0\,26 10,0.73
98.06
60 100.64 95.E1 100,69 104,78 t00.64
15 99.61 100.91 98,?0 9,80 9.72 I0070
90 97.82 10t.23 98,90 t00.62 98.18 100.91 100.75
I0t 9.87 102.18 98.47
120 10t.35 I00.73 100.48 %,70 r03.48 99.'
12