Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...

stsftl,rd w6 4.2 ninut s Estectively. The sylt m suiLbility of the nethod ss esr.blished
by injddrs six Fpli@r.s of ! edd.rd slurion dd nNitre r[. BFBS (!6t a6) of
The Elative sl$dard d.viation ofd. six pek Espon$s ws nol foud gEaler rbe 2%
vrhich colfimed tte suitrbility of ihe mrbod. SFciflciry of ttE m€rhod ws d.boBilaet by
gerdtlg rcprelcniarive .hrcmdoerms (Iigre 3.1) ro lhow ihal rhe othe. conDoncnh thai
@uld b. p@nl in r[. mdc mrit @ @tv.d tm de p.mt edyc.
No signifiHr cheges in AUC or rcre ion rine of ttE d{8s in p,.sncc &d abence of
.xcipients clorly indic.lcd rbd specificiry of rh€ De$od. For limairy siudi€e. dle *ri6 of
@nqlra$o6 of the d$g in t. mge 3.12-50 lrgbt L w€E prcpard, calibotion cwe fol
Ors m8. w$ dal@ted, Th. tin@ Eg6sion .q@rion foud for 1his mg. ws y = l0o89x
+ 19100 ed lild @mcis1 valE b foud ro be 0.999. Thc del[od peision w
p.rfom.d by fou iepaFdalive s@plcs on c&h of 2 days, The ..rimaled prection (toi.l
vdation) non virhin day qFd|Mr h ob*d€d io bc ls rhd 2% RSD. Th. nerhod
p6s.d lhe lest for rcpealabiliry N derenin d by 0/oRSD of $e rca of rbe peaks of six
Gpliclr. inj€.rioB d t00/. t s c()l@r{ion hbte 3.6. nle csutts of intedcdiare pRisio,
Aeu@y of the ndhod *s cv.turd
thc ditrtul indepod.nl onadrdions
i,c. 8, 10. 12 !g EIr for dl 0E degs
(n=6) by drlting lnom q@rili$ of rhe
.ubL io rhe drug Pl0der Th. 6ult of
a€'@y (llble 3.7) Ev€sled lhat ft€
h.tl'od vs det€ for all oSoE pu.pos.
w.E der.mircd (rlbte 3.7).
l0 25 20 3t2
0.22 1.05
0.62 088
Icbl.' (q"RsDJ 021 065
0.25 t12 0ll
t02.45
8f,
l9Der and e8n^ ity ohh. n.thad
%RSD LOD L()()
0.8.1
019
0_22
ne LOD dd LOQ v.tks for drllftnr drnes