Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
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ABSTRACT<br />
S*ond ee.enrion erihisLm<strong>in</strong> s N p.glycoprote<strong>in</strong> subsrdles. Drugs i.nibn<strong>in</strong>e oi <strong>in</strong>du<strong>in</strong>g<br />
Fglycoprcie<strong>in</strong> nodoldtion day l€ad io drug-dog <strong>in</strong>ierrctions. C€iriz<strong>in</strong>e dihydrochbnde. a<br />
sond c4oation dtihist h<strong>in</strong>ey' b also a potenr substdie <strong>of</strong>p,glycoFore<strong>in</strong>s.<br />
In th€ presenl wort, e attenpl yas madc ro devclop a nunb.r ol HPLC nelhods for<br />
simullan€ous q@<strong>tn</strong>alion <strong>of</strong> c.ti z<strong>in</strong>c ed orher drugs, ehi.h my posibly be<br />
coadnirbted. fte lali dqss <strong>in</strong>clud. Hrr€@pror dragooisi G<strong>in</strong>etitt<strong>in</strong>e, rmolidire and<br />
miid<strong>in</strong>e), st ris (al<strong>of</strong>latat<strong>in</strong>' Guvalai4 pr.var.r<strong>in</strong> dd simvsbr<strong>in</strong>), qu<strong>in</strong>oloie<br />
etibscterial asotr (lcvonoxac<strong>in</strong>. o0ow<strong>in</strong>, cip.<strong>of</strong>lorciD, .@x&ir, sprfloxd<strong>in</strong> dd<br />
rcrflosc<strong>in</strong>), c.lciM chmcl blocreu (dilli@m, v.rpdil. mlodip<strong>in</strong>o, non nmidal etii.flmalory<br />
drues (ri,t<strong>of</strong>cn& &id, dicl<strong>of</strong>.n& sodih 0ubiprcfeq ibup<strong>of</strong>eD. m€f€mic<br />
&id and ndonm} etimrluiak (prrio.thM<strong>in</strong>e qd cholorcquim), dridrhnadc druss<br />
Guifencsia phmyl€phi<strong>in</strong>. &d noncluLsd), ccph.losporitu (@toid@, cphlt xitr ed<br />
ertuim.) od dtuss ued <strong>in</strong> non iBul<strong>in</strong> deFndcnr diab.Ls mllirur (re{omia<br />
slibeklamid€ ard elqudone, Th. /d.v.toF!l mdhodi *4 validaEd 4d w mpid.<br />
on@icd and w€E fourt sujratte tor orri"e JJysi"_or d*s druss' iiom 6w nateri.tsphrm@tical<br />
doss. foru ed ir hltlfu etu.<br />
G<strong>tn</strong>iziF is 0!e m6t widely pdsibcd drus for allcteic dierd€s ed is .vail.bL <strong>in</strong><br />
@mb<strong>in</strong>adon with l|ny olhr drugs <strong>in</strong> mny couries. Due lo rhe po$ibiliiy <strong>of</strong> cedri<strong>tn</strong>e<br />
<strong>in</strong>k&don * r othd drugs, dng <strong>in</strong>r.tuti@r <strong>of</strong> ednz<strong>in</strong>e r@ sMi.d wi$ atl lhe abov€<br />
sLt d dogs. The abore Dstior.d m.rhods w.E appli.d 10 sndy thc po$ible r" rfo<br />
i erurions B<strong>in</strong>g uv visible s!E*Aii*c. -o HpLc r.€hiiqoe <strong>in</strong> s<strong>in</strong>ulated body<br />
aviremmIs at 3?!c ed ar pH I Gimular<strong>in</strong>s mFy sbhach), pH 4 (s<strong>in</strong>ulatjng tuu<br />
slol@h), pH 7.4 Gimulat<strong>in</strong>s bl@d pH) dd ar pu 9 Gimuj.t<strong>in</strong>s <strong>in</strong>rclr<strong>in</strong>al pH).<br />
From <strong>tn</strong>€* <strong>in</strong>reEtion studies. ir 6 cvidenr $ar rh.rc wss no chsge irff,ailabihy <strong>of</strong><br />
.el<strong>in</strong>/<strong>in</strong>e <strong>in</strong>tpRsence ol b, <strong>of</strong> $.s. drusr cxcept srmv6Et<strong>in</strong> ud NSA|Ds. Itese<br />
i erulioE wre futher v.dfied by 3ynrhesiz<strong>in</strong>g conptei€s <strong>of</strong> ceilizie wiln th€s druss<br />
which llw.hdaderizd by us<strong>in</strong>g FT-IR ed |H-NMR. Encryy m<strong>in</strong>imiation studi€s ed<br />
k<strong>in</strong>dics <strong>of</strong>th€e comDl€x€s werc also studicd,<br />
In orde! lo study lbe struduE elivity relafioNhip, vdious d.logu$ ol cet<strong>in</strong>z<strong>in</strong>€ wer€<br />
plepded. The rcagenls <strong>in</strong>chded ph.nyl.n€didi.., phlbalimid., thioacelmide, thioua md
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