Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Clw@terizclon of tL*Mi. ,1cid in Di&tu',t Pho@dicd Dotuge Fw.d tn ...
Create successful ePaper yourself
Turn your PDF publications into a flip-book with our unique Google optimized e-Paper software.
kela.@n@le withoul ihc <strong>in</strong>cEbed nlk <strong>of</strong> head iGguldiiies @mo! to 0$6 rcn-sedal<strong>in</strong>s<br />
&li hLlte<strong>in</strong>* 1561. How*o, MAO irnibiloE ifttte the cfel <strong>of</strong> synpalbomim.tic<br />
dires sd may prolong md ifldsiry the.frec' <strong>of</strong> dlibislan<strong>in</strong>$. No dde irt @lions had<br />
bei Eponed wilh th. @ <strong>of</strong> poa.eihol [57]. Il is hishly $letivc i! tu <strong>in</strong>rc@tion *irh<br />
v&ious boooml b<strong>in</strong>d<strong>in</strong>g sir6 md hiShly porenr krfenad<strong>in</strong>€ d well. No wdio roxic eflcrs<br />
wE ob*ncd wiih rh. nw &ug wncn u*d al its e@m€nded or hi8ns do*s or whd<br />
adn<strong>in</strong>ht€rcd with imidaale ednDeal od n&olide edbiotics. How.ver. orher rypical<br />
drug <strong>in</strong>l€rutioro <strong>of</strong> Hr odnistdire applr 10 eriiz<strong>in</strong>e. As.ltiriz<strong>in</strong>e is a edalive drug, e il<br />
should not be talen along wilh alcohols or CNS supprc$<strong>in</strong>e drugs I58l,<br />
The ccdnz<strong>in</strong>e l0 ng do noi <strong>in</strong>te@t wilh al@hol ir two studics bul some dighr addnive<br />
efects wre .Lt@led <strong>in</strong> morhd [59-61]. Uha e <strong>in</strong>rcBction @cured, it appeed lo he due<br />
to d!. @rb<strong>in</strong>.d or lddifie enrd neryos d.DMl.ffet5 <strong>of</strong> both lhc atcohol od th€<br />
mdnist.m<strong>in</strong>e 1621. lr had bee. obsened that both c€tiliz<strong>in</strong>e t0 mg alone <strong>in</strong> onb<strong>in</strong>ation with<br />
ni@sulide 100 ng d.c@d wheal !d fle Esrone sisrifi@tly !r 2 hou6 and lhe<br />
€spose cont<strong>in</strong>u€d to decr€ase dll 6 how post dosilg. Th€ d4re6e M nuch hore wh€n<br />
onbi..ri@ <strong>of</strong> cet<strong>in</strong>nne ed nimdulid€ @ 8iyo 3 @mp.Fd lo c.ridt@ alotre. This<br />
sugSesl€d a synergistic €if*t ot cetiriz<strong>in</strong>e ed nimdulid€ therc sd no study reporle'l $ fr<br />
show<strong>in</strong>g dy phmcody.uic dd ph.@oL<strong>in</strong> ti6 i e@don beiwcq n<strong>in</strong>6did. &d<br />
cetuizjne. PhmMdynmics <strong>in</strong>e@tion wa noE Dlausible for resulrs obla<strong>in</strong>ed 4<br />
n<strong>in</strong>esulide h.d ben aponed to hav. borh dli <strong>in</strong>Jldnsrory and $rihi$an<strong>in</strong>ic actilities<br />
[63]. Dose rDponion l cmd valEs wd€ @hi.ved wirh<strong>in</strong> I hor <strong>of</strong> onl adh<strong>in</strong>ist.arion or<br />
arnizie. CoBisre wit! rbe polr @tur <strong>of</strong> this @tbxtlic @id dru& l.s th& I tr^ <strong>of</strong> p.d<br />
pldna ld€ls had b€en m@rd io th. bm<strong>in</strong>. Celirirne m.ol €xlosilel! nebboliad ed<br />
70qlo <strong>of</strong>the l0 ns w6 excrclcd <strong>in</strong> th€ u<strong>in</strong> an
Change language